Patents by Inventor Jonathan M. BRUNGER

Jonathan M. BRUNGER has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROGRAMMED CELLS FOR TARGETED ARTICULAR CARTILAGE AND BONE REGENERATION
    Publication number: 20230295262
    Abstract: The disclosure describes engineered cells for the treatment of joint and bone disease. The cells are engineered to sense signals only found in diseased compartments and in turn produce therapeutic molecules that are secreted into the local environment.
    Type: Application
    Filed: March 10, 2023
    Publication date: September 21, 2023
    Applicants: Vanderbilt University, University of Tennessee Research Foundation
    Inventors: Jonathan M. Brunger, Karen A. Hasty, Bonnie L. Walton, Craig L. Duvall
  • COMPOSITIONS, SYSTEMS AND METHODS FOR CELL THERAPY
    Publication number: 20220315946
    Abstract: Disclosed herein are compositions and methods for cell therapy comprising an engineered cell. The present invention is directed to a composition for treating a subject having or suspected of having a disease, the composition comprising a modified cell comprising a modified endogenous gene, wherein an endogenous gene or fragment thereof is replaced with a transgene using a CRISPR/Cas9 system to generate the modified endogenous gene, the modified cell having an altered response to a cell signal or stimulus.
    Type: Application
    Filed: March 16, 2022
    Publication date: October 6, 2022
    Inventors: Farshid Guilak, Jonathan M. Brunger, Charles A. Gersbach
  • Compositions, systems and methods for cell therapy
    Patent number: 11319555
    Abstract: Disclosed herein are compositions and methods for cell therapy comprising an engineered cell. The present invention is directed to a composition for treating a subject having or suspected of having a disease, the composition comprising a modified cell comprising a modified endogenous gene, wherein an endogenous gene or fragment thereof is replaced with a transgene using a CRISPR/Cas9 system to generate the modified endogenous gene, the modified cell having an altered response to a cell signal or stimulus.
    Type: Grant
    Filed: November 20, 2015
    Date of Patent: May 3, 2022
    Assignee: Duke University
    Inventors: Farshid Guilak, Jonathan M. Brunger, Charles A. Gersbach
  • COMPOSITIONS, SYSTEMS AND METHODS FOR CELL THERAPY
    Publication number: 20180201951
    Abstract: Disclosed herein are compositions and methods for cell therapy comprising an engineered cell. The present invention is directed to a composition for treating a subject having or suspected of having a disease, the composition comprising a modified cell comprising a modified endogenous gene, wherein an endogenous gene or fragment thereof is replaced with a transgene using a CRISPR/Cas9 system to generate the modified endogenous gene, the modified cell having an altered response to a cell signal or stimulus.
    Type: Application
    Filed: November 20, 2015
    Publication date: July 19, 2018
    Inventors: Farshid Guilak, Jonathan M. Brunger, Charles A. Gersbach
  • Cortical tenting screw
    Patent number: 8968373
    Abstract: An implantable screw system for maintaining horizontal and/or vertical space during bone grafting procedures is provided, the screw comprising: a contoured head having a region adapted to support soft tissue and permit bone growth; a threaded shaft and a tip adapted to penetrate bone tissue; and where one screw contains a threaded chamber for engaging a second screw for additional space maintenance; wherein the screw(s) comprises cortical bone material. Methods of implanting one or more screws during bone grating procedures are disclosed.
    Type: Grant
    Filed: July 24, 2008
    Date of Patent: March 3, 2015
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Jonathan M. Brunger, Jeffrey M. Badura, James B. Thomas
  • CORTICAL TENTING SCREW
    Publication number: 20100023064
    Abstract: An implantable screw system for maintaining horizontal and/or vertical space during bone grafting procedures is provided, the screw comprising: a contoured head having a region adapted to support soft tissue and permit bone growth; a threaded shaft and a tip adapted to penetrate bone tissue; and where one screw contains a threaded chamber for engaging a second screw for additional space maintenance; wherein the screw(s) comprises cortical bone material. Methods of implanting one or more screws during bone grating procedures are disclosed.
    Type: Application
    Filed: July 24, 2008
    Publication date: January 28, 2010
    Applicant: Warsaw Orthopedic, Inc.
    Inventors: Jonathan M. BRUNGER, Jeffrey M. Badura, James B. Thomas