Patents by Inventor Jonathan M. Cassel
Jonathan M. Cassel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11807900Abstract: Some embodiments presented in this disclosure concern an Automated Tissue Dissection (ATD) System. An ATD system is a one stop, and potentially low-cost, system to perform dissections on a substrate from pathologist digital mark or pen mark on the substrate using non-contact and/or mechanical method to extract a Formalin-Fixed Paraffin-Embedded (FFPE) tissue sample with: (a) only the ROI or ROIs as area to be saved; and (b) remove or decompose nucleic acid content in the region of no interest (RONI) and collect all tissue sample from a standard microscope substrate into a specific container.Type: GrantFiled: June 21, 2019Date of Patent: November 7, 2023Assignee: Genomic Health, Inc.Inventors: Hubert Yeung, Amy Lee Hsieh Yuan, Chun Wai Lee, Gabriel Jesus Samuel Perlas Moraleda, Jonathan M. Cassel
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Publication number: 20230096149Abstract: The present disclosure provides reagents that can be used to label synthetic oligonucleotides with rhodamine dyes or dye networks that contain rhodamine dyes.Type: ApplicationFiled: June 30, 2022Publication date: March 30, 2023Applicant: Applied Biosystems, LLCInventors: Scott C. Benson, Ruiming N. Zou, Krishna G. Upadhya, Paul M. Kenney, Jonathan M. Cassel
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Patent number: 11407773Abstract: The present disclosure provides reagents that can be used to label synthetic oligonucleotides with rhodamine dyes or dye networks that contain rhodamine dyes.Type: GrantFiled: January 30, 2020Date of Patent: August 9, 2022Assignee: Applied Biosystems, LLCInventors: Scott C. Benson, Ruiming N. Zou, Krishna G. Upadhya, Paul M. Kenney, Jonathan M. Cassel
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Publication number: 20200270287Abstract: The present disclosure provides reagents that can be used to label synthetic oligonucleotides with rhodamine dyes or dye networks that contain rhodamine dyes.Type: ApplicationFiled: January 30, 2020Publication date: August 27, 2020Applicant: Applied Biosystems, LLCInventors: Scott C. Benson, Ruiming N. Zou, Krishna G. Upadhya, Paul M. Kenney, Jonathan M. Cassel
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Publication number: 20190390252Abstract: Some embodiments presented in this disclosure concern an Automated Tissue Dissection (ATD) System. An ATD system is a one stop, and potentially low-cost, system to perform dissections on a substrate from pathologist digital mark or pen mark on the substrate using non-contact and/or mechanical method to extract a Formalin-Fixed Paraffin-Embedded (FFPE) tissue sample with: (a) only the ROI or ROIs as area to be saved; and (b) remove or decompose nucleic acid content in the region of no interest (RONI) and collect all tissue sample from a standard microscope substrate into a specific container.Type: ApplicationFiled: June 21, 2019Publication date: December 26, 2019Inventors: Hubert Yeung, Amy Lee Hsieh Yuan, Chun Wai Lee, Gabriel Jesus Samuel Perlas Moraleda, Jonathan M. Cassel
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Publication number: 20180057516Abstract: The present disclosure provides reagents that can be used to label synthetic oligonucleotides with rhodamine dyes or dye networks that contain rhodamine dyes.Type: ApplicationFiled: September 1, 2017Publication date: March 1, 2018Applicant: Applied Biosystems, LLCInventors: Scott C. Benson, Ruiming N. Zou, Krishna G. Upadhya, Paul M. Kenney, Jonathan M. Cassel
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Patent number: 9783560Abstract: The present disclosure provides reagents that can be used to label synthetic oligonucleotides with rhodamine dyes or dye networks that contain rhodamine dyes.Type: GrantFiled: May 1, 2015Date of Patent: October 10, 2017Assignee: Applied Biosystems, LLCInventors: Scott C. Benson, Ruiming N. Zou, Krishna G. Upadhya, Paul M. Kenney, Jonathan M. Cassel
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Publication number: 20150232494Abstract: The present disclosure provides reagents that can be used to label synthetic oligonucleotides with rhodamine dyes or dye networks that contain rhodamine dyes.Type: ApplicationFiled: May 1, 2015Publication date: August 20, 2015Inventors: Scott C. BENSON, Ruiming N. ZOU, Krishna G. UPADHYA, Paul M. KENNEY, Jonathan M. CASSEL
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Patent number: 9040674Abstract: The present disclosure provides reagents that can be used to label synthetic oligonucleotides with rhodamine dyes or dye networks that contain rhodamine dyes.Type: GrantFiled: April 2, 2007Date of Patent: May 26, 2015Assignee: Applied Biosystems, LLCInventors: Scott C. Benson, Ruiming N. Zou, Krishna G. Upadhya, Paul M. Kenney, Jonathan M. Cassel
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Publication number: 20090023189Abstract: Methods and systems for forming water-in-oil emulsions are described. For example, an apparatus is described which includes: a first compartment containing a plurality of particles dispersed in an aqueous phase; a second compartment containing an oil phase; a porous layer separating the first and second compartments; and a device for applying pressure to the first compartment. A method is described which includes: moving an oil phase relative to a surface of a porous layer while simultaneously forcing an aqueous composition comprising particles through the porous layer and into the flowing dispersion medium thereby forming droplets of the aqueous composition containing particles dispersed in the oil phase. The aqueous composition can include one or more nucleic acid templates and reagents for amplifying the nucleic acids such as PCR reagents.Type: ApplicationFiled: May 12, 2008Publication date: January 22, 2009Applicant: APPLERA CORPORATIONInventors: Aldrich N.K. Lau, Jonathan M. Cassel, John A. Bridgham
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Patent number: 6025505Abstract: A class of 4,7-dichlororhodamine compounds useful as fluorescent dyes are disclosed having the structure ##STR1## wherein R.sub.1 -R.sub.6 are hydrogen, fluorine, chlorine, lower alkyl, lower alkene, lower alkyne, sulfonate, sulfone, amino, amido, nitrile, lower alkoxy, linking group, or combinations thereof, or, when taken together, R.sub.1 and R.sub.6 is benzo, or, when taken together, R.sub.4 and R.sub.5 is benzo; Y.sub.1 -Y.sub.4 are hydrogen or lower alkyl, or, when taken together, Y.sub.1 and R.sub.2, Y.sub.2 and R.sub.1 Y.sub.3 and R.sub.3, or Y.sub.4 and R.sub.4 is propano, ethano, or substituted forms thereof, and X.sub.1 -X.sub.3 taken separately are selected from the group consisting of hydrogen, chlorine, fluorine, lower alkyl, carboxylate, sulfonic acid, --CH.sub.2 OH, and linking group. In another aspect, the invention includes reagents labeled with the 4,7-dichlororhodamine dye compounds, including deoxynucleotides, dideoxynucleotides, and polynucleotides.Type: GrantFiled: March 10, 1998Date of Patent: February 15, 2000Assignee: The Perkin-Elmer CorporationInventors: Linda G. Lee, Scott C. Benson, Barnett B. Rosenblum, Sandra L. Spurgeon, Jonathan M. Cassel, Ronald J. Graham
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Patent number: 6017712Abstract: A class of 4,7-dichlororhodamine compounds useful as fluorescent dyes are disclosed having the structure ##STR1## wherein R.sub.1 -R.sub.6 are hydrogen, fluorine, chlorine, lower alkyl, lower alkene, lower alkyne, sulfonate, sulfone, amino, amido, nitrile, lower alkoxy, linking group, or combinations thereof, or, when taken together, R.sub.1 and R.sub.6 is benzo, or, when taken together, R.sub.4 and R.sub.5 is benzo; Y.sub.1 -Y.sub.4 are hydrogen or lower alkyl, or, when taken together, Y.sub.1 and R.sub.2, Y.sub.2 and R.sub.1 Y.sub.3 and R.sub.3, or Y.sub.4 and R.sub.4 is propano, ethano, or substituted forms thereof; and X.sub.1 -X.sub.3 taken separately are selected from the group consisting of hydrogen, chlorine, fluorine, lower alkyl, carboxylate, sulfonic acid, --CH.sub.2 OH, and linking group. In another aspect, the invention includes reagents labeled with the 4,7-chlororhodamine dye compounds, including deoxynucleotides, dideoxynucleotides, and polynucleotides.Type: GrantFiled: November 12, 1998Date of Patent: January 25, 2000Inventors: Linda Lee, Scott C. Benson, Barnett B. Rosenblum, Sandra L. Spurgeon, Jonathan M. Cassel, Ronald J. Graham
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Patent number: 5744107Abstract: Heavy metals are efficiently removed from contaminated soil by a process which comprises leaching or washing the soil with a mild leachant solution. The leachant solution is comprised of an aqueous solution of an acid and a salt. The anion of the acid forms a water-soluble salt with the heavy metals which contaminate the soil. The salt component is comprised of at least one alkali metal, alkaline earth metal, or an ammonium salt having one or more anions which also form a water-soluble salt with the heavy metals leached from the contaminated soil.Type: GrantFiled: December 16, 1994Date of Patent: April 28, 1998Assignee: Henkel CorporationInventors: William E. Fristad, Michael J. Virnig, Jonathan M. Cassel
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Patent number: 5639894Abstract: A process for the carbonylation of allylic alcohols such as nerolidol, farnesol, or their monocyclic analogues with carbon monoxide at a pressure of at least 30 bar in the presence of a polar solvent and a palladium halide catalyst, optionally an alkali metal halide salt, and optionally an alcoholic solvent. The carbonylated product may then be reduced to the corresponding alcohol, which is cyclized in the presence of Lewis or Bronsted acids to afford an ambergris fragrance compound.Type: GrantFiled: March 23, 1994Date of Patent: June 17, 1997Assignee: Henkel Kommanditgesellschaft auf AktienInventors: Jonathan M. Cassel, Steven M. Hoagland, James M. Renga
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Patent number: 5494649Abstract: Heavy metals are removed from paint chips by leaching with an aqueous acid. Heavy metals are also efficiently removed from contaminated soil by a process which comprises leaching or washing the soil with a mild leachant solution comprised of an aqueous solution of an acid and a salt. The heavy metals are recovered from the leachant by cementation.Type: GrantFiled: August 17, 1992Date of Patent: February 27, 1996Assignee: Cognis, Inc.Inventors: William E. Fristad, Michael J. Virnig, Jonathan M. Cassel, Dana K. Elliot
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Patent number: 5326885Abstract: Enriched enantiomers of glycerol Carbonate are produced under the influence of a hydrolytic enzyme, either by selective esterification of racemic glycerol carbonate or by selective hydrolysis of an ester of the racemate. The enriched enantiomeric product is readily converted to starting materials and intermediates useful in the synthesis of enantiomerically pure therapeutic agents, such as .beta.-adrenergic blockers.Type: GrantFiled: October 21, 1993Date of Patent: July 5, 1994Assignee: Cognis, Inc.Inventors: Alan G. Olivero, Jonathan M. Cassel, James R. Poulsen
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Patent number: 5326888Abstract: A process for the carbonylation of allylic alcohols such as nerolidol, farnesol, or their monocyclic analogues with carbon monoxide at a pressure of at least 30 bar in the presence of a polar solvent and a palladium halide catalyst, optionally an alkali metal halide salt, and optionally an alcoholic solvent. The carbonylated product may then be reduced to the corresponding alcohol, which is cyclized in the presence of Lewis or Bronsted acids to afford an ambergris fragrance compound.Type: GrantFiled: October 9, 1990Date of Patent: July 5, 1994Assignee: Henkel Research CorporationInventors: Jonathan M. Cassel, Steven M. Hoagland, James M. Renga