Abstract: A system for managing reduced pressure to a wound site includes a wound enclosure configured to form a substantially sealed volume around the wound site, a first closed volume, a second closed volume, and a controller. The first closed volume includes a primary pressure source and a canister fluidly coupled to the primary pressure source. The first closed volume is configured to apply reduced pressure to the wound site and deliver exudate collected from the wound site to the canister through a first lumen. The second closed volume includes a secondary pressure source and is configured to apply a secondary pressure to the wound site through a second lumen to facilitate flow of the exudate from the wound site to the canister through the first lumen. The controller is configured to communicate with at least the second closed volume for selectively applying the secondary pressure to the wound site.