Patents by Inventor Jonathan M. Graff

Jonathan M. Graff has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • “Signalin” family of TGF? signal transduction proteins, and uses related thereto
    Patent number: 7034114
    Abstract: The present invention concerns the discovery that proteins encoded by a family of vertebrate genes, termed here signalin-related genes, which are involved in signal transduction induced by members of the TGF? superfamily. The present invention makes available compositions and methods that can be utilized, for example to generate and/or maintain an array of different vertebrate tissue both in vitro and in vivo.
    Type: Grant
    Filed: March 12, 2002
    Date of Patent: April 25, 2006
    Assignee: President and Fellows of Harvard College
    Inventors: Jonathan M. Graff, Tod M. Woolf, Ping Jin, Douglas A. Melton
  • Methods to identify signal sequences
    Publication number: 20030157486
    Abstract: The present invention provides screening methods using bacterial cells to identify nucleic acid sequences encoding eukaryotic proteins comprising signal sequences and/or transmembrane sequences. Provided are several breast cancer and adipose tissue nucleic acid and proteins sequences that encode proteins comprising signal sequences and/or transmembrane sequences. Also provided are diagnostic methods and kits that utilize the proteins identified by the present methods to diagnose and detect diseases, physiological states and conditions, including cancer and those associated with fat metabolism.
    Type: Application
    Filed: October 31, 2001
    Publication date: August 21, 2003
    Inventors: Jonathan M. Graff, Matthew Muenster
  • ''Signalin'' family of TGFbeta signal transduction proteins, and uses related thereto
    Publication number: 20020146773
    Abstract: The present invention concerns the discovery that proteins encoded by a family of vertebrate genes, termed here signalin-related genes, which are involved in signal transduction induced by members of the TGF&bgr; superfamily. The present invention makes available compositions and methods that can be utilized, for example to generate and/or maintain an array of different vertebrate tissue both in vitro and in vivo.
    Type: Application
    Filed: March 12, 2002
    Publication date: October 10, 2002
    Inventors: Jonathan M. Graff, Tod M. Woolf, Ping Jin, Douglas A. Melton
  • Signalin family of TGF&bgr; signal transduction proteins, and uses related thereto
    Patent number: 6428977
    Abstract: The present invention concerns the discovery that proteins encoded by a family of vertebrate genes, termed here signalin-related genes, which are involved in signal transduction induced by members of the TGF&bgr; superfamily. The present invention makes available compositions and methods that can be utilized, for example to generate and/or maintain an array of different vertebrate tissue both in vitro and in vivo.
    Type: Grant
    Filed: December 20, 1995
    Date of Patent: August 6, 2002
    Assignee: Curis, Inc.
    Inventors: Jonathan M. Graff, Tod M. Woolf, Ping Jin, Douglas A. Melton