Patents by Inventor Jonathan M. Rothberg

Jonathan M. Rothberg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PERISTALTIC PUMPING OF FLUIDS FOR BIOANALYTICAL APPLICATIONS AND ASSOCIATED METHODS, SYSTEMS, AND DEVICES
    Publication number: 20210121875
    Abstract: Embodiments described herein generally relate to apparatuses, cartridges, and pumps for peristaltic pumping of fluids and associated methods, systems, and devices. The pumping of fluids is, in certain cases, an important aspect of a variety of applications, such as bioanalytical applications (e.g., biological sample analysis, sequencing, identification). The inventive features described herein may, in some embodiments, provide an ability to pump fluids in ways that combine certain advantages of robotic fluid handling systems (e.g., automation, programmability, configurability, flexibility) with certain advantages of microfluidics (e.g., small fluid volumes with high fluid resolution, precision, monolithic consumables, limiting of the wetting of components to consumables).
    Type: Application
    Filed: October 28, 2020
    Publication date: April 29, 2021
    Applicant: Quantum-Si Incorporated
    Inventors: Jonathan M. Rothberg, Jonathan C. Schultz, John H. Leamon, Todd Roswech, Xiaxiao Ma
  • SYSTEMS AND METHODS FOR SAMPLE PREPARATION
    Publication number: 20210121879
    Abstract: Methods and devices for isolating or enriching target molecules from a sample are provided herein. In some embodiments, methods and devices further involve detection, analysis and/or sequencing of a target molecule.
    Type: Application
    Filed: October 28, 2020
    Publication date: April 29, 2021
    Applicant: Quantum-Si Incorporated
    Inventors: Jonathan M. Rothberg, John H. Leamon, Jonathan C. Schultz, Michele Millham, Caixia Lv, Xiaxiao Ma
  • PERISTALTIC PUMPING OF FLUIDS AND ASSOCIATED METHODS, SYSTEMS, AND DEVICES
    Publication number: 20210121874
    Abstract: Embodiments described herein generally relate to apparatuses, cartridges, and pumps for peristaltic pumping of fluids and associated methods, systems, and devices. The pumping of fluids is, in certain cases, an important aspect of a variety of applications, such as bioanalytical applications (e.g., biological sample analysis, sequencing, identification). The inventive features described herein may, in some embodiments, provide an ability to pump fluids in ways that combine certain advantages of robotic fluid handling systems (e.g., automation, programmability, configurability, flexibility) with certain advantages of microfluidics (e.g., small fluid volumes with high fluid resolution, precision, monolithic consumables, limiting of the wetting of components to consumables).
    Type: Application
    Filed: October 28, 2020
    Publication date: April 29, 2021
    Applicant: Quantum-Si Incorporated
    Inventors: Jonathan M. Rothberg, Jonathan C. Schultz, John H. Leamon, Todd Roswech, Xiaxiao Ma
  • Magnetic coil power methods and apparatus
    Patent number: 10989776
    Abstract: An apparatus to provide power for operating at least one gradient coil of a magnetic resonance imaging system. According to some aspects, the apparatus comprises a plurality of power terminals configured to supply different voltages of a first polarity, and a linear amplifier configured to provide at least one output to power the at least one gradient coil to produce a magnetic field in accordance with a pulse sequence, the linear amplifier configured to be powered by one or more of the plurality of power terminals, wherein the one or more of the plurality of power terminals powering the linear amplifier is selected based, at least in part, on the at least one output.
    Type: Grant
    Filed: March 29, 2019
    Date of Patent: April 27, 2021
    Assignee: Hyperfine Research, Inc.
    Inventors: William J. Mileski, Gregory L. Charvat, Jonathan M. Rothberg, Jeremy Christopher Jordan
  • CMOS ULTRASONIC TRANSDUCERS AND RELATED APPARATUS AND METHODS
    Publication number: 20210114060
    Abstract: CMOS Ultrasonic Transducers and processes for making such devices are described. The processes may include forming cavities on a first wafer and bonding the first wafer to a second wafer. The second wafer may be processed to form a membrane for the cavities. Electrical access to the cavities may be provided.
    Type: Application
    Filed: October 30, 2020
    Publication date: April 22, 2021
    Applicant: Butterfly Network, Inc.
    Inventors: Jonathan M. Rothberg, Keith G. Fife, Tyler S. Ralston, Gregory L. Charvat, Nevada J. Sanchez
  • Interconnectable ultrasound transducer probes and related methods and apparatus
    Patent number: 10980511
    Abstract: Ultrasound devices and methods are described, including a repeatable ultrasound transducer probe having ultrasonic transducers and corresponding circuitry. The repeatable ultrasound transducer probe may be used individually or coupled with other instances of the repeatable ultrasound transducer probe to create a desired ultrasound device. The ultrasound devices may optionally be connected to various types of external devices to provide additional processing and image rendering functionality.
    Type: Grant
    Filed: February 1, 2017
    Date of Patent: April 20, 2021
    Assignee: Butterfly Network, Inc.
    Inventors: Jonathan M. Rothberg, Keith G. Fife, Nevada J. Sanchez, Tyler S. Ralston, Gregory L. Charvat, Gregory Corteville
  • Bead emulsion nucleic acid amplification
    Patent number: 10982274
    Abstract: Disclosed are methods for nucleic acid amplification wherein nucleic acid templates, beads, and amplification reaction solution are emulsified and the nucleic acid templates are amplified to provide clonal copies of the nucleic acid templates attached to the beads. Also disclosed are kits and apparatuses for performing the methods of the invention.
    Type: Grant
    Filed: January 16, 2019
    Date of Patent: April 20, 2021
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Jan Berka, Yi-Ju Chen, John H. Leamon, Steven Lefkowitz, Kenton L. Lohman, Vinod B. Makhijani, Jonathan M. Rothberg, Gary J. Sarkis, Maithreyan Srinivasan, Michael P. Weiner
  • CHEMICALLY-SENSITIVE SENSOR ARRAY CALIBRATION CIRCUITRY
    Publication number: 20210109060
    Abstract: Methods and apparatus relating to very large scale FET arrays for analyte measurements. ChemFET (e.g., ISFET) arrays may be fabricated using conventional CMOS processing techniques based on improved FET pixel and array designs that increase measurement sensitivity and accuracy, and at the same time facilitate significantly small pixel sizes and dense arrays. Improved array control techniques provide for rapid data acquisition from large and dense arrays. Such arrays may be employed to detect a presence and/or concentration changes of various analyte types in a wide variety of chemical and/or biological processes. In one example, chemFET arrays facilitate DNA sequencing techniques based on monitoring changes in hydrogen ion concentration (pH), changes in other analyte concentration, and/or binding events associated with chemical processes relating to DNA synthesis.
    Type: Application
    Filed: October 9, 2020
    Publication date: April 15, 2021
    Applicant: Life Technologies Corporation
    Inventors: Jonathan M. ROTHBERG, Wolfgang HINZ, Kim L. JOHNSON, James BUSTILLO
  • Automated image acquisition for assisting a user to operate an ultrasound device
    Patent number: 10959702
    Abstract: Aspects of the technology described herein relate to techniques for guiding an operator to use an ultrasound device. Thereby, operators with little or no experience operating ultrasound devices may capture medically relevant ultrasound images and/or interpret the contents of the obtained ultrasound images. For example, some of the techniques disclosed herein may be used to identify a particular anatomical view of a subject to image with an ultrasound device, guide an operator of the ultrasound device to capture an ultrasound image of the subject that contains the particular anatomical view, and/or analyze the captured ultrasound image to identify medical information about the subject.
    Type: Grant
    Filed: June 19, 2017
    Date of Patent: March 30, 2021
    Assignee: Butterfly Network, Inc.
    Inventors: Daniel Nouri, Alex Rothberg, Matthew de Jonge, Jimmy Jia, Jonathan M. Rothberg, Michal Sofka, Abraham Neben
  • Systems and methods for automated detection in magnetic resonance images
    Patent number: 10955504
    Abstract: Some aspects include a method of detecting change in biological subject matter of a patient positioned within a low-field magnetic resonance imaging device, the method comprising: while the patient remains positioned within the low-field magnetic resonance device: acquiring first magnetic resonance image data of a portion of the patient; acquiring second magnetic resonance image data of the portion of the patient subsequent to acquiring the first magnetic resonance image data; aligning the first magnetic resonance image data and the second magnetic resonance image data; and comparing the aligned first magnetic resonance image data and second magnetic resonance image data to detect at least one change in the biological subject matter of the portion of the patient.
    Type: Grant
    Filed: November 21, 2017
    Date of Patent: March 23, 2021
    Assignee: Hyperfine Research, Inc.
    Inventors: Michal Sofka, Jonathan M. Rothberg, Gregory L. Charvat, Tyler S. Ralston
  • Pulse sequences for low field magnetic resonance
    Patent number: 10955500
    Abstract: A low-field magnetic resonance imaging (MRI) system. The system includes a plurality of magnetics components comprising at least one first magnetics component configured to produce a low-field main magnetic field B0 and at least one second magnetics component configured to acquire magnetic resonance data when operated, and at least one controller configured to operate one or more of the plurality of magnetics components in accordance with at least one low-field zero echo time (LF-ZTE) pulse sequence.
    Type: Grant
    Filed: March 2, 2020
    Date of Patent: March 23, 2021
    Assignee: Hyperfine Research, Inc.
    Inventors: Laura Sacolick, Matthew Scot Rosen, Gregory L. Charvat, Jonathan M. Rothberg, Mathieu Sarracanie
  • Systems and methods for unifying statistical models for different data modalities
    Patent number: 10956787
    Abstract: Techniques for performing a prediction task using a multi-modal statistical model configured to receive input data from multiple modalities including input data from a first modality and input data from a second modality different from the first modality.
    Type: Grant
    Filed: May 8, 2019
    Date of Patent: March 23, 2021
    Assignee: Quantum-Si Incorporated
    Inventors: Jonathan M. Rothberg, Umut Eser, Michael Meyer
  • PIKFYVE INHIBITORS FOR CANCER THERAPY
    Publication number: 20210077500
    Abstract: The present disclosure relates methods for treating a cancer having activated MET or RAS pathway signaling using an inhibitor of PIKfyve, alone or in combination with a MET inhibitor or a RAS pathway inhibitor, and related compositions and methods to identify PIKfyve inhibitor sensitive cancers for targeted treatment.
    Type: Application
    Filed: September 10, 2020
    Publication date: March 18, 2021
    Inventors: Sean Landrette, Neil Beeharry, Peter R. Young, Jonathan M. Rothberg, Tian Xu, Henri Lichenstein
  • TECHNIQUES FOR SEMI-SUPERVISED TRAINING AND ASSOCIATED APPLICATIONS
    Publication number: 20210073648
    Abstract: Described herein are semi-supervised machine learning techniques and associated computer-implemented applications. Some aspects provide a system configured to identify associations among data input to the system. In some embodiments, the system may map the input data to one or more vector spaces, such that associated groups of the input data form associated clusters in the vector space(s). For example, the mapping may be performed by one or more trained encoders (e.g., neural network encoders) of the system. Accordingly, a distance separating two data entries in a space may indicate a likelihood of association among the data entries. Various applications of such systems are described herein.
    Type: Application
    Filed: September 3, 2020
    Publication date: March 11, 2021
    Inventors: Henri Lichenstein, Bradley Robert Parry, Jonathan M. Rothberg, Tian Xu
  • AUGMENTED REALITY INTERFACE FOR ASSISTING A USER TO OPERATE AN ULTRASOUND DEVICE
    Publication number: 20210052249
    Abstract: Aspects of the technology described herein relate to techniques for guiding an operator to use an ultrasound device. Thereby, operators with little or no experience operating ultrasound devices may capture medically relevant ultrasound images and/or interpret the contents of the obtained ultrasound images. For example, some of the techniques disclosed herein may be used to identify a particular anatomical view of a subject to image with an ultrasound device, guide an operator of the ultrasound device to capture an ultrasound image of the subject that contains the particular anatomical view, and/or analyze the captured ultrasound image to identify medical information about the subject.
    Type: Application
    Filed: November 9, 2020
    Publication date: February 25, 2021
    Applicant: Butterfly Network, Inc.
    Inventors: Tomer Gafner, Matthew de Jonge, Robert Schneider, David Elgena, Alex Rothberg, Jonathan M. Rothberg, Michal Sofka, Karl Thiele, Abraham Neben
  • METHODS AND APPARATUS FOR MEASURING ANALYTES USING LARGE SCALE FET ARRAYS
    Publication number: 20210047686
    Abstract: Methods and apparatus relating to very large scale FET arrays for analyte measurements. ChemFET (e.g., ISFET) arrays may be fabricated using conventional CMOS processing techniques based on improved FET pixel and array designs that increase measurement sensitivity and accuracy, and at the same time facilitate significantly small pixel sizes and dense arrays. Improved array control techniques provide for rapid data acquisition from large and dense arrays. Such arrays may be employed to detect a presence and/or concentration changes of various analyte types in a wide variety of chemical and/or biological processes. In one example, chemFET arrays facilitate DNA sequencing techniques based on monitoring changes in the concentration of inorganic pyrophosphate (PPi), hydrogen ions, and nucleotide triphosphates.
    Type: Application
    Filed: May 22, 2020
    Publication date: February 18, 2021
    Inventors: Jonathan M. Rothberg, Wolfgang Hinz, Kim L. Johnson, James Bustillo, John Leamon, Jonathan Schultz
  • Low-field magnetic resonance imaging methods and apparatus
    Patent number: 10921404
    Abstract: According to some aspects, a low-field magnetic resonance imaging system is provided. The low-field magnetic resonance imaging system comprises a magnetics system having a plurality of magnetics components configured to produce magnetic fields for performing magnetic resonance imaging, the magnetics system comprising, a B0 magnet, a plurality of gradient coils, and at least one radio frequency coil, a power system comprising one or more power components configured to provide power to the magnetics system to operate the magnetic resonance imaging system to perform image acquisition, and a power connection configured to connect to a single-phase outlet to receive mains electricity and deliver the mains electricity to the power system to provide power needed to operate the magnetic resonance imaging system.
    Type: Grant
    Filed: April 3, 2020
    Date of Patent: February 16, 2021
    Assignee: Hyperfine Research, Inc.
    Inventors: Michael Stephen Poole, Cedric Hugon, Hadrien A. Dyvorne, Laura Sacolick, William J. Mileski, Jeremy Christopher Jordan, Alan B. Katze, Jr., Jonathan M. Rothberg, Todd Rearick, Christopher Thomas McNulty
  • Radio frequency coil methods and apparatus
    Patent number: 10912517
    Abstract: Aspects relate to providing radio frequency components responsive to magnetic resonance signals. According to some aspects, a radio frequency component comprises at least one coil having a conductor arranged in a plurality of turns oriented about a region of interest to respond to corresponding magnetic resonant signal components. According to some aspects, the radio frequency component comprises a plurality of coils oriented to respond to corresponding magnetic resonant signal components. According to some aspects, an optimization is used to determine a configuration for at least one radio frequency coil.
    Type: Grant
    Filed: October 3, 2018
    Date of Patent: February 9, 2021
    Assignee: Hyperfine Research, Inc.
    Inventors: Michael Stephen Poole, Gregory L. Charvat, Todd Rearick, Jonathan M. Rothberg
  • METHOD FOR TREATING CANCER USING HSP90 INHIBITORS
    Publication number: 20210030759
    Abstract: The disclosure also provides compositions and methods related to combination therapy with HSP90 inhibitors and BCL-2 pathway inhibitors for treating cancer. The disclosure also provides compositions and methods related to the use of ‘low dose’ HSP90 inhibitors in the treatment of cancer, alone and in combination with other therapeutic agents.
    Type: Application
    Filed: September 23, 2020
    Publication date: February 4, 2021
    Inventors: Neil Beeharry, Marylens Hernandez, Sean Landrette, Tian Xu, Jonathan M. Rothberg, Henri Lichenstein
  • INTEGRATED DEVICE FOR TEMPORAL BINNING OF RECEIVED PHOTONS
    Publication number: 20210025823
    Abstract: An integrated circuit includes a photodetection region configured to receive incident photons. The photodetection region is configured to produce a plurality of charge carriers in response to the incident photons. The integrated circuit also includes at least one charge carrier storage region. The integrated circuit also includes a charge carrier segregation structure configured to selectively direct charge carriers of the plurality of charge carriers into the at least one charge carrier storage region based upon times at which the charge carriers are produced.
    Type: Application
    Filed: August 4, 2020
    Publication date: January 28, 2021
    Applicant: Quantum-Si Incorporated
    Inventors: Jonathan M. Rothberg, Keith G. Fife, David M. Boisvert