Patents by Inventor Jonathan M. Rubin
Jonathan M. Rubin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230165567Abstract: A method of estimating lung motion (e.g., local lung motion and local lung ventilation) includes collecting a time series of ultrasound images of a lung surface, the time series including a plurality of frames, identifying a lung surface in one of the plurality of frames, and subsetting each of the plurality of frames into at least one sub-image. The method further includes applying a high pass temporal filter and a spatial filter. The method still further includes calculating inter-frame motion data from complex data sets associated with one or more pairs of temporally successive frames. In a further method, lung surface longitudinal strain is also calculated.Type: ApplicationFiled: May 7, 2021Publication date: June 1, 2023Inventors: Jonathan M. Rubin, J. Brian Fowlkes, Oliver D. Kripfgans, James D. Hamilton, Christopher Fung
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Patent number: 11529122Abstract: A method of evaluating tissue stiffness of a target area includes positioning an ultrasound elasticity imaging apparatus adjacent a surface of an area of tissue where the target area is located and applying a dynamic range of force to the tissue. A plurality of ultrasound beams can be directed at the tissue and a plurality of ultrasound echoes can be acquired from the strained tissue in the target area to calculate an amount of developed strain within the target area.Type: GrantFiled: December 23, 2019Date of Patent: December 20, 2022Assignees: University of Pittsburgh—Of the Commonwealth System of Higher Education, The Regents of the University of MichiganInventors: Kang Kim, Jingping Xu, Jonathan M Rubin
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Publication number: 20220087647Abstract: A method of estimating lung motion includes collecting multiple ultrasound image data captured at one or more locations of a sample region of tissue. The method further includes comparing the multiple ultrasound image data and determining temporal correlation coefficients between each of the multiple ultrasound image data. The method still further includes displaying an image of the sample region of the tissue with the temporal correlation coefficients identified, thereby indicating lung motion. In further methods, the determined temporal correlation coefficients are used to determine an amount of decorrelation, which can be used to determine strain of the tissue over the sample region and to calculate lung displacements and lung shape changes representing ventilation.Type: ApplicationFiled: February 5, 2020Publication date: March 24, 2022Inventors: Jonathan M. Rubin, James D. Hamilton, Oliver D. Kripfgans, J. Brian Fowlkes
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Publication number: 20200146654Abstract: A method of evaluating tissue stiffness of a target area includes positioning an ultrasound elasticity imaging apparatus adjacent a surface of an area of tissue where the target area is located and applying a dynamic range of force to the tissue. A plurality of ultrasound beams can be directed at the tissue and a plurality of ultrasound echoes can be acquired from the strained tissue in the target area to calculate an amount of developed strain within the target area.Type: ApplicationFiled: December 23, 2019Publication date: May 14, 2020Applicants: University of Pittsburgh - Of the Commonwealth System of Higher Education, The Regents of the University of MichiganInventors: Kang Kim, Jingping Xu, Jonathan M Rubin
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Patent number: 10258277Abstract: A system and method for determining fractional fat content of tissue comprises registering thermoacoustic image coordinates to an acquired ultrasound image, the acquired ultrasound image at least comprising target tissue within a region of interest; defining a thermoacoustic voxel grid coincident with the region of interest; obtaining thermoacoustic image measurement values from tissue within the region of interest corresponding to the voxels within the defined thermoecoustic voxel grid to yield a thermoacoustic measurement matrix; normalizing the thermoacoustic image measurement values within the thermoacoustic measurement matrix; calculating a fractional fat content map for the target tissue within the region of interest based on the normalized thermoacoustic image measurement values within the thermoacoustic measurement matrix and a reference thermoacoustic measurement value; and correcting the fractional fat content map based on tissue speed-of-sound data to yield a final fractional fat content map for thType: GrantFiled: June 14, 2018Date of Patent: April 16, 2019Assignee: ENDRA Life Sciences Inc.Inventors: Jonathan M. Rubin, Michael M. Thornton, Aghapi Mordovanakis
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Publication number: 20190038220Abstract: A system and method for determining fractional fat content of tissue comprises registering thermoacoustic image coordinates to an acquired ultrasound image, the acquired ultrasound image at least comprising target tissue within a region of interest; defining a thermoacoustic voxel grid coincident with the region of interest; obtaining thermoacoustic image measurement values from tissue within the region of interest corresponding to the voxels within the defined thermoecoustic voxel grid to yield a thermoacoustic measurement matrix; normalizing the thermoacoustic image measurement values within the thermoacoustic measurement matrix; calculating a fractional fat content map for the target tissue within the region of interest based on the normalized thermoacoustic image measurement values within the thermoacoustic measurement matrix and a reference thermoacoustic measurement value; and correcting the fractional fat content map based on tissue speed-of-sound data to yield a final fractional fat content map for thType: ApplicationFiled: June 14, 2018Publication date: February 7, 2019Applicant: ENDRA Life Sciences Inc.Inventors: Jonathan M. Rubin, Michael M. Thornton, Aghapi Mordovanakis
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Publication number: 20170100099Abstract: A method of evaluating tissue stiffness of a target area includes positioning an ultrasound elasticity imaging apparatus adjacent a surface of an area of tissue where the target area is located and applying a dynamic range of force to the tissue. A plurality of ultrasound beams can be directed at the tissue and a plurality of ultrasound echoes can be acquired from the strained tissue in the target area to calculate an amount of developed strain within the target area.Type: ApplicationFiled: December 22, 2016Publication date: April 13, 2017Applicants: University of Pittsburgh - Of the Commonwealth System of Higher Education, The Regents of the University of MichiganInventors: Kang Kim, Jingping Xu, Jonathan M. Rubin
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Patent number: 9554777Abstract: A method of evaluating tissue stiffness of a target area includes positioning an ultrasound elasticity imaging apparatus adjacent a surface of an area of tissue where the target area is located and applying a dynamic range of force to the tissue. A plurality of ultrasound beams can be directed at the tissue and a plurality of ultrasound echoes can be acquired from the strained tissue in the target area to calculate an amount of developed strain within the target area.Type: GrantFiled: May 23, 2012Date of Patent: January 31, 2017Assignees: University of Pittsburgh—Of the Commonwealth System of Higher Education, The Regents of the University of MichiganInventors: Kang Kim, Jingping Xu, Jonathan M. Rubin
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Publication number: 20140094702Abstract: A method of evaluating tissue stiffness of a target area includes positioning an ultrasound elasticity imaging apparatus adjacent a surface of an area of tissue where the target area is located and applying a dynamic range of force to the tissue. A plurality of ultrasound beams can be directed at the tissue and a plurality of ultrasound echoes can be acquired from the strained tissue in the target area to calculate an amount of developed strain within the target area.Type: ApplicationFiled: May 23, 2012Publication date: April 3, 2014Applicants: The Regents of the University of Michigan, University of Pittsburgh - Of the Commonwealth System of Higher EducationInventors: Kang Kim, Jingping Xu, Jonathan M. Rubin
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Patent number: 8167804Abstract: An optimized elastic modulus reconstruction procedure can estimate the nonlinear elastic properties of vascular wall from intramural strain and pulse wave velocity (PWV) measurements. A noninvasive free-hand ultrasound scanning procedure is used to apply external force, comparable to the force in measuring a subject's blood pressure, to achieve higher strains by equalizing the internal arterial baseline pressure. PWV is estimated at the same location where intramural strain is measured. The reconstructed elastic modulus is optimized and the arterial elastic modulus can be determined and monitored using a simple dual elastic modulus reconstruction procedure.Type: GrantFiled: October 2, 2007Date of Patent: May 1, 2012Assignee: The Regents of the University of MichiganInventors: Kang Kim, William F. Weitzel, Jonathan M. Rubin, Congxian Jia, Matthew O'Donnell, Theodore J. Kolias
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Patent number: 7542544Abstract: An ultrasonic imaging system acquires echo signals from an object being imaged such as a moving coronary artery and the cross-correlation between echo signals is employed as an objective measure of relative object location. The method is used in a prescan procedure to determine an optimal gating window to acquire image data during a cardiac gated scan, and it is used during the scan as a real time gating signal.Type: GrantFiled: January 5, 2005Date of Patent: June 2, 2009Assignee: The Regents of the University of MichiganInventors: Jonathan M. Rubin, Jeffrey Brian Fowlkes, Charles R. Meyer, Srini Tridandapani
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Patent number: 7318804Abstract: Methods and systems for measuring mechanical property of a vascular wall and a method and system for determining health of a vascular structure are provided wherein local deformation of a vessel wall resulting from physiologic pressures with altered transmural forces is measured. A non-invasive free-hand ultrasound scanning-procedure was performed to apply external force, comparable to the force generated in measuring a subject's blood pressure, to achieve higher strains by equalizing the internal arterial baseline pressure. When the applied pressure matched the internal baseline diastolic pressure, strain and strain rate increased by a factor of 10 over a cardiac cycle. Radial arterial strain was assessed in the vessel wall over the entire deformation procedure using a phase-sensitive, two-dimensional speckle-tracking algorithm. An elastic modulus reconstruction procedure was developed to estimate the non-linear elastic properties of the vascular wall.Type: GrantFiled: December 9, 2003Date of Patent: January 15, 2008Assignee: The Regents of the University of MichiganInventors: William F. Weitzel, Kang Kim, Matthew O'Donnell, Jonathan M. Rubin, Hua Xie, Xunchang Chen
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Patent number: 7154987Abstract: An x-ray CT system performs a scan by acquiring projection views from which an image is reconstructed. In a prospective embodiment, the correlation of adjacent views is calculated as the scan is performed and is used to detect subject motion as the scan is being performed. In a retrospective embodiment, the correlation of adjacent views is calculated and is used to detect subject motion after the scan is completed. In the first embodiment substitute projection views are acquired by continuing the scan and in the second embodiment redundant projection views acquired during the scan are substituted until the best possible image is produced.Type: GrantFiled: September 8, 2005Date of Patent: December 26, 2006Assignee: The Regents of the University of MichiganInventors: Jonathan M. Rubin, Benoit Desjardins, J. Brian Fowlkes, Srini Tridandapani
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Patent number: 6709414Abstract: A system and method are provided for determining the performance of a vessel, such as a hemodialysis access, which communicates blood between two locations of a patient. A conduit, such as an external dialysis circuit or an intravascular catheter, is provided in fluid communication with the vessel, and has a diversion point for diverting blood from the vessel into the conduit. The system further includes means for determining a flow rate of the diverted blood through the conduit. A first sensor in communication with the vessel generates at least one signal that is a function of a blood flow rate in the vessel downstream from the diversion point, wherein the downstream flow rate depends on the determined conduit flow rate and the performance of the vessel can be determined based on the signal. In addition, a processor can be provided in communication with the first sensor for determining a flow rate in the vessel upstream from the diversion point from the signal and the conduit flow rate.Type: GrantFiled: February 21, 2003Date of Patent: March 23, 2004Assignee: The Regents of the University of MichiganInventors: William F. Weitzel, Jonathan M. Rubin, Joseph M. Messana
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Publication number: 20030195413Abstract: An MRI system includes an ultrasonic detector system that includes an ultrasonic transducer placed to detect movement of selected anatomic structure in a patient. The transducer signal is analyzed to produce a gating signal which is used by the MRI system to trigger data acquisition.Type: ApplicationFiled: May 19, 2003Publication date: October 16, 2003Inventors: Jonathan M. Rubin, Jeffrey B. Fowlkes, Charles R. Meyer
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Publication number: 20030167030Abstract: A system and method are provided for determining the performance of a vessel, such as a hemodialysis access, which communicates blood between two locations of a patient. A conduit, such as an external dialysis circuit or an intravascular catheter, is provided in fluid communication with the vessel, and has a diversion point for diverting blood from the vessel into the conduit. The system further includes means for determining a flow rate of the diverted blood through the conduit. A first sensor in communication with the vessel generates at least one signal that is a function of a blood flow rate in the vessel downstream from the diversion point, wherein the downstream flow rate depends on the determined conduit flow rate and the performance of the vessel can be determined based on the signal. In addition, a processor can be provided in communication with the first sensor for determining a flow rate in the vessel upstream from the diversion point from the signal and the conduit flow rate.Type: ApplicationFiled: February 21, 2003Publication date: September 4, 2003Applicant: The Regents of the University of MichiganInventors: William F. Weitzel, Jonathan M. Rubin, Joseph M. Messana
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Patent number: 6575927Abstract: A system and method are provided for determining the performance of a vessel, such as a hemodialysis access, which communicates blood between two locations of a patient. A conduit, such as an external dialysis circuit or an intravascular catheter, is provided in fluid communication with the vessel, and has a diversion point for diverting blood from the vessel into the conduit. The system further includes means for determining a flow rate of the diverted blood through the conduit. A first sensor in communication with the vessel generates at least one signal that is a function of a blood flow rate in the vessel downstream from the diversion point, wherein the downstream flow rate depends on the determined conduit flow rate and the performance of the vessel can be determined based on the signal. In addition, a processor can be provided in communication with the first sensor for determining a flow rate in the vessel upstream from the diversion point from the signal and the conduit flow rate.Type: GrantFiled: May 12, 1999Date of Patent: June 10, 2003Assignee: The Regents of the University of MichiganInventors: William F. Weitzel, Jonathan M. Rubin, Joseph M. Messana
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Patent number: 6535835Abstract: The volume of fluid flow within a vessel (VE) is measured by an ultrasound system. Ultrasound waves backscattered from the fluid within the vessel generate data from which velocity values representing components of velocity (Vx and Vy) of the fluid flow in the scan plane (IP) are calculated. Grayscale data is correlated and the rate of decorrelation (D) of the data is calculated. The volume flow of the fluid (F) is estimated in response to the velocity signals and the rate of decorrelation (D).Type: GrantFiled: January 31, 2000Date of Patent: March 18, 2003Assignees: GE Medical Systems Global Technology Company, LLC, The Regents of the University of MichiganInventors: Jonathan M. Rubin, Jeffrey Brian Fowlkes, Theresa Ann Tuthill, Anne Lindsey Hall
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Patent number: 6059727Abstract: A 3D image data set representing a volume of material such as human tissue is created using speckle decorrelation techniques to process successive 2D data slices from a moving, standard 1D or 1.5D ultrasound transducer. This permits the use of standard ultrasound machinery, without the use of additional slice-position hardware, to create 3D images without having to modify the machinery or its operation. Similar techniques can be used for special data processing within the imaging system as well to expedite the image acquisition process. Optionally, the image quality of 2D images can be enhanced through the use of multiple 3D data sets derived using the method.Type: GrantFiled: April 13, 1998Date of Patent: May 9, 2000Assignee: The Regents of the University of MichiganInventors: J. Brian Fowlkes, Paul L. Carson, Aaron Moskalik, Jian-Feng Chen, Jonathan M. Rubin
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Patent number: 5860929Abstract: A method for quantitatively estimating the amount of tissue that contains moving blood using power Doppler ultrasound. A region of interest is identified from a frozen image (i.e., a snapshot screen display created by displaying the last real-time image for a given scan). The region of interest is specified by using a pointing device (e.g., a mouse). An object that contains one hundred percent blood flow and is located at the same depth as the region of interest, but not necessarily inside the region of interest, is identified and the corresponding power noted and designated as the reference power level. The display is adjusted to show the one hundred percent blood flow vessel in a designated color (such as, for example, green) and all other power levels are normalized to the reference power level. The fractional blood volume is quantitatively estimated by summing the normalized Doppler power levels in a region of interest and dividing the sum by the number of pixels in region of interest.Type: GrantFiled: June 7, 1996Date of Patent: January 19, 1999Assignee: The Regents of the University of MichiganInventors: Jonathan M. Rubin, Ronald S. Adler, J. Brian Fowlkes, Ray Steven Spratt