Patents by Inventor Jonathan Madec

Jonathan Madec has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for preparing 1,3-dihydroimidazole-2-thione derivatives
    Patent number: 10059696
    Abstract: The present invention relates to a process for preparing (R)-5-(2-(benzylamino)ethyl)-1-(6,8-difluorochroman-3-yl)-1H-imidazole-2(3H)-thione, and pharmaceutically acceptable salts thereof, especially the hydrochloride salt. The invention also relates to a process for making intermediates useful in the formation of said compound, and to the intermediates, per se.
    Type: Grant
    Filed: February 23, 2016
    Date of Patent: August 28, 2018
    Assignee: Bial-Portela & CA, S.A.
    Inventors: Alexander Beliaev, Jorge Bruno Reis Wahnon, David Alexander Learmonth, Jonathan Madec, Jean-Marie Schneider, William Maton
  • Process for preparing cinacalcet and pharmaceutically acceptable salts thereof
    Patent number: 9598350
    Abstract: The present patent application relates to a process for preparing cinacalcet or a pharmaceutically acceptable salt thereof, which comprises reacting 3-trifluoromethylbenzaldehyde having the following formula (II) with the phosphorus-comprising derivative having the following formula (III) in which R1 and R2, which may be identical or different, are each a (C1-C6)alkyl group. The present invention also relates to the phosphorus-comprising derivative having the formula (III), to the use thereof and to the process for preparing same. The present invention also relates to the phosphate salt of cinacalcet and to uses thereof.
    Type: Grant
    Filed: March 21, 2016
    Date of Patent: March 21, 2017
    Assignee: Produits Chimiques Auxiliaries et de Synthese
    Inventors: Jean-Marie Schneider, Jonathan Madec, Sergio Kreimerman, Gerard Guillamot
  • Process
    Publication number: 20160311804
    Abstract: The present invention relates to a process for preparing (R)-5-(2-(benzylamino)ethyl)-1-(6,8-difluorochroman-3-yl)-1H-imidazole-2(3H)-thione, and pharmaceutically acceptable salts thereof, especially the hydrochloride salt. The invention also relates to a process for making intermediates useful in the formation of said compound, and to the intermediates, per se.
    Type: Application
    Filed: February 23, 2016
    Publication date: October 27, 2016
    Inventors: Alexander BELIAEV, Jorge Bruno Reis WAHNON, David Alexander LEARMONTH, Jonathan MADEC, Jean-Marie SCHNEIDER, William MATON
  • Process for Preparing Cinacalcet and Pharmaceutically Acceptable Salts Thereof
    Publication number: 20160200664
    Abstract: The present patent application relates to a process for preparing cinacalcet or a pharmaceutically acceptable salt thereof, which comprises reacting 3-trifluoromethylbenzaldehyde having the following formula (II) with the phosphorus-comprising derivative having the following formula (III) in which R1 and R2, which may be identical or different, are each a (C1-C6)alkyl group. The present invention also relates to the phosphorus-comprising derivative having the formula (III), to the use thereof and to the process for preparing same. The present invention also relates to the phosphate salt of cinacalcet and to uses thereof.
    Type: Application
    Filed: March 21, 2016
    Publication date: July 14, 2016
    Applicant: Produits Chimiques Auxiliaires et de Synthese
    Inventors: Jean-Marie Schneider, Jonathan Madec, Sergio Kreimerman, Gerard Guillamot
  • Process for preparing 1, 3-Dihydroimidazole-2-Thione Derivatives
    Patent number: 9346751
    Abstract: The present invention relates to a process for preparing (R)-5-(2-(benzylamino)ethyl)-1-(6,8-difluorochroman-3-yl)-1H-imidazole-2(3H)-thione, and pharmaceutically acceptable salts thereof, especially the hydrochloride salt. The invention also relates to a process for making intermediates useful in the formation of said compound, and to the intermediates, per se.
    Type: Grant
    Filed: June 29, 2012
    Date of Patent: May 24, 2016
    Assignee: Bial-Portela & CA, S.A.
    Inventors: Alexander Beliaev, Jorge Bruno Reis Wahnon, David Alexander Learmonth, Jonathan Madec, Jean-Marie Schneider, William Maton
  • Method for the preparation of (3S,3S?) 4,4?-disulfanediylbis (3-aminobutane 1-sulfonic acid)
    Patent number: 9340497
    Abstract: The present invention relates to a new method for the preparation of (3S,3S?) 4,4?-disulfanediylbis(3-aminobutane 1-sulfonic acid) in five steps from (S)-ethyl 2-(benzyloxycarbonylamino)-4-(neopentyloxysulfonyl)butanoate A.
    Type: Grant
    Filed: October 27, 2015
    Date of Patent: May 17, 2016
    Assignee: QUANTUM GENOMICS
    Inventors: Fabrice Balavoine, Jonathan Madec, Jean-Marie Schneider, Gerard Coquerel, Nicolas Couvrat, Yohann Cartigny, Marie-Noelle Petit
  • Process for preparing cinacalcet and pharmaceutically acceptable salts thereof
    Patent number: 9290439
    Abstract: The present patent application relates to a process for preparing, cinacalcet or a pharmaceutically acceptable salt thereof, which comprises reacting 3-trifluoromethylbenzaldehyde having the following formula (II) with the phosphorus-comprising derivative having the following formula (III) in which R1 and R2, which may be identical or different, are each a (C1-C6)alkyl group. The present invention also relates to the phosphorus-comprising derivative having the formula (III), to the use thereof and to the process for preparing same. The present invention also relates to the phosphate salt of cinacalcet and to uses thereof.
    Type: Grant
    Filed: September 9, 2013
    Date of Patent: March 22, 2016
    Assignee: Produits Chimiques Auxiliaires et de Synthese
    Inventors: Jean-Marie Schneider, Jonathan Madec, Sergio Kreimerman, Gerard Guillamot
  • METHOD FOR THE PREPARATION OF (3S,3S') 4,4'-DISULFANEDIYLBIS (3-AMINOBUTANE 1-SULFONIC ACID)
    Publication number: 20160046571
    Abstract: The present invention relates to a new method for the preparation of (3S,3S?) 4,4?-disulfanediylbis(3-aminobutane 1-sulfonic acid) in five steps from (S)-ethyl 2-(benzyloxycarbonylamino)-4-(neopentyloxysulfonyl)butanoate A.
    Type: Application
    Filed: October 27, 2015
    Publication date: February 18, 2016
    Inventors: Fabrice BALAVOINE, Jonathan MADEC, Jean-Marie SCHNEIDER, Gerard COQUEREL, Nicolas COUVRAT, Yohann CARTIGNY, Marie-Noelle PETIT
  • Method for the preparation of (3S, 3S?) 4,4?-disulfanediylbis (3-aminobutane 1-sulfonic acid)
    Patent number: 9187418
    Abstract: The present invention relates to a new method for the preparation of (3S,3S?) 4,4?-disulfanediylbis(3-aminobutane 1-sulfonic acid) in five steps from (S)-ethyl 2-(benzyloxycarbonylamino)-4-(neopentyloxysulfonyl)butanoate A.
    Type: Grant
    Filed: October 7, 2011
    Date of Patent: November 17, 2015
    Assignee: QUANTUM GENOMICS
    Inventors: Fabrice Balavoine, Jonathan Madec, Jean-Marie Schneider, Gérard Coquerel, Nicolas Couvrat, Yohann Cartigny, Marie-Noëlle Petit
  • Process for Preparing Cinacalcet and Pharmaceutically Acceptable Salts Thereof
    Publication number: 20150246869
    Abstract: The present patent application relates to a process for preparing, cinacalcet or a pharmaceutically acceptable salt thereof, which comprises reacting 3-trifluoromethylbenzaldehyde having the following formula (II) with the phosphorus-comprising derivative having the following formula all) in which R1 and R2, which may he identical or different, are each a (C1-C6)alkyl group. The present invention also relates to the phosphorus-comprising derivative having the formula (III), to the use thereof and to the process for preparing same. The present invention also relates to the phosphate salt of cinacalcet and to uses thereof.
    Type: Application
    Filed: September 9, 2013
    Publication date: September 3, 2015
    Inventors: Jean-Marie Schneider, Jonathan Madec, Sergio Kreimerman, Gerard Guillamot
  • Process
    Publication number: 20140221668
    Abstract: The present invention relates to a process for preparing (R)-5-(2-(benzylamino)ethyl)-1-(6,8-difluorochroman-3-yl)-1H-imidazole-2(3H)-thione, and pharmaceutically acceptable salts thereof, especially the hydrochloride salt. The invention also relates to a process for making intermediates useful in the formation of said compound, and to the intermediates, per se.
    Type: Application
    Filed: June 29, 2012
    Publication date: August 7, 2014
    Applicant: BIAL-PORTELA & CA, S.A.
    Inventors: Alexander Beliaev, Jorge Bruno Reis Wahnon, David Alexander Learmonth, Jonathan Madec, Jean-Marie Schneider, William Maton
  • METHOD FOR THE PREPARATION OF (3S, 3S') 4,4'-DISULFANEDIYLBIS (3-AMINOBUTANE 1-SULFONIC ACID)
    Publication number: 20130231500
    Abstract: The present invention relates to a new method for the preparation of (3S,3S?) 4,4?-disulfanediylbis(3-aminobutane 1-sulfonic acid) in five steps from (S)-ethyl 2-(benzyloxycarbonylamino)-4-(neopentyloxysulfonyl)butanoate A.
    Type: Application
    Filed: October 7, 2011
    Publication date: September 5, 2013
    Applicant: QUANTUM GEOMICS
    Inventors: Fabrice Balavoine, Jonathan Madec, Jean-Marie Schneider, Gérard Coquerel, Nicolas Couvrat, Yohann Cartigny, Marie-Noëlle Petit