Abstract: A tracker for a navigation system. A tracker body defines an opening, and a lens is positionable to seal the opening. A plug is configured to be coupled to the tracker body to secure the lens. A tracking element may be disposed between the lens and the plug so as to be visible through the lens. The tracking element may be disposed within a sealed enclosure defined by the lens and the plug. The plug may define a counterbore in fluid communication with the opening, and the plug may be at least partially disposed within the counterbore. The plug may further define a groove, and the tracker may include a sealing element disposed within the groove. The plug may include a shoulder configured to in sealing engagement with the tracker body. Methods of assembling the tracker for use with the navigation system are also disclosed.

Abstract: The present invention relates to compounds of Formula I that function as inhibitors of RET (rearranged during transfection) kinase enzyme activity: wherein HET, bonds a, b, c and d, X1, X2, X3, X4, R2, and R3 are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which RET kinase activity is implicated.

Abstract: Disclosed are compounds, compositions, and methods useful for treating neuronal and mitochondrial diseases.

Abstract: Disclosed are compounds, compositions, and methods useful for treating neuronal and mitochondrial diseases.

Abstract: First and second tracker assemblies each having a single optical marker are secured to a bone, with the first tracker assembly also including a motion sensor. A localizer optically tracks the optical marker positions, and a pose of a tracker coordinate system (TCS) associated with the tracker assemblies according to three positional DOF and two rotational DOF is determined from the tracked marker positions. Measurements from the motion sensor are utilized to determine an angle of inclination with respect to gravity, and an orientation of the TCS according to a further rotational DOF defined about a virtual line extending between the optical markers is determined from the angle of inclination. A pose of the bone according to six DOF is then determined from the determined pose of the TCS according to three positional and two rotational DOF and the orientation of the TCS according to the further rotational DOF.

Abstract: A monitoring system is disclosed comprises a passive infrared, PIR, detector configured for detecting motion in an environment and an active reflected wave detector arranged to measure wave reflections from a region of interest in the environment. The active reflected wave detector is operable responsive to detection of motion by the PIR detector. The system is configured to adjust at least one parameter of the PIR detector responsive to the output of the active reflected wave detector meeting one or more criteria. A method, controller and computer program product are also disclosed.

Abstract: Embodiments relate to a device and method for determining a status of an environment and/or a status or condition of a person therein. The method may comprise: receiving an output of a sensor to monitor said environment; commencing a time window after the sensor detects activity in the environment; upon expiry of the time window, activating an active reflected wave detector to measure wave reflections from the environment, the detector consuming more power in an activated state than the sensor in an activated state; and determining a status of the environment and/or of a person therein based on an output of the active detector indicative of one or more of the measured reflections. The method comprises delaying expiry of the time window in response to the sensor detecting activity in the environment during the time window.

Abstract: An example primer set includes first and second nuclease resistant primers. The first nuclease resistant primer includes a first sequence; a first cleavage site attached at a 3? end of the first sequence; and a first nuclease resistant modification incorporated between the first sequence and the first cleavage site. The second nuclease resistant primer includes a second sequence that is different from the first sequence; a second nuclease resistant modification incorporated at a 3? end of the second sequence; and a second cleavage site attached between the second sequence and the second nuclease resistant modification. The second cleavage site is different from the first cleavage site.

Abstract: This disclosure provides systems, devices, apparatus, and methods, including computer programs encoded on storage media, for filtering a dataset. The apparatus may receive, via a user interface, a natural language input for a search of the dataset. The natural language input is an unstructured input. The apparatus maps the unstructured input to one or more filters associated with the natural language input based on execution of a generative AI model. The mapping of the unstructured input transforms the unstructured input into a structured input. The apparatus outputs, via the user interface, a result of the search based on an application of the one or more filters to the dataset.

Abstract: A subsea connector assembly for coupling a spool member to a wellhead member, comprising a connector and a bending moment suppression device coupled to the connector. The connector includes a lock assembly configured to engage a first portion of a wellhead member. The bending moment suppression device is configured to engage a second portion of the wellhead member, wherein the second portion is spaced axially from the first portion.

Abstract: This disclosure provides systems, devices, apparatus, and methods, including computer programs encoded on storage media, for filtering a dataset. The apparatus may receive, via a user interface, a natural language input for a search of the dataset. The natural language input is an unstructured input. The apparatus maps the unstructured input to one or more filters associated with the natural language input based on execution of a generative AI model. The mapping of the unstructured input transforms the unstructured input into a structured input. The apparatus outputs, via the user interface, a result of the search based on an application of the one or more filters to the dataset.

Abstract: Surgical systems and methods involve a first and second trackers with trackable elements and which are independently secured to a bone and separated by a distance. A localizer tracks the trackable elements. Controller(s) define a tracking arrangement based on a combination of the trackable elements from the trackers. The controller(s) register a geometry of the tracking arrangement relative to the bone and track the bone by detection of the registered geometry. The controller(s) detect a condition wherein at least one trackable element has been displaced relative to the registered geometry. The controller(s) register a position of an anatomical landmark of the bone and use the landmark to identify the at least one trackable element that has been displaced.

Abstract: Embodiments relate to a device and method of controlling monitoring of a person or an environment. The method comprises determining information about a person or an environment using an output of an operation of an active reflective wave detector configured to measure wave reflections from an environment. The method further comprises, based on the information, adapting one or more parameters of a triggering module used for starting a later operation of the active reflected wave detector to determine further information about the person or the environment, the later operation being started based on an output of a PIR motion detector that is arranged to monitor motion in the environment, the output indicating that a motion has occurred after said operation of an active reflective wave detector.

Abstract: Methods of operating electric motor systems that comprise electric motors comprising a rotor having a magnet mounted thereto. The electric motor is initially operated in an open loop mode in which the rotor angle is estimated based on the input voltage frequency. Once the motor is running at sufficient speed, a transition to closed loop mode operation is performed, wherein the rotor angle is determined using an observed back EMF. To provide a smoother open loop to closed loop transition, the rotor angle is determined during a transition period as a function of both the open loop rotor angle and the closed loop rotor angle.

Abstract: A patient interface can have a frame supporting a sealing member. Various features of the sealing member can improve comfort and sealing performance in the context of forming seals with the nares of a user, as well as contact with other facial surfaces. The sealing member can include convex portions, concave portions and thickness variations for providing various sealing, comfort, and deformability effects.

Abstract: The invention relates to methods and kits for use in nucleic acid sequencing, in particular methods for use in concurrent sequencing, and in particular concurrent sequencing of tandem insert libraries.

Abstract: A person support apparatus, such as a bed, stretcher, cot, recliner, or the like, includes an exit detection system having a plurality of force sensors that support the weight of an occupant positioned on a support surface. The force sensors are part of an exit detection system that issues an alarm when the occupant exits, or is about to exit, the person support apparatus. The distribution of weight applied to the force sensors is used to determine if the occupant is about to exit the person support apparatus. Compensation is made to the exit detection system for changes in the weight distribution that are not caused by movement of the occupant. Such changes may be due to siderail movement, support surface pivoting, and/or movement of other components of the person support apparatus.

Abstract: An electronic rotor “lock” that can be implemented within an electric motor system by selecting closing a subset of switches within an inverter of the motor drive system to create a circulatory current path that can generate a force that acts to oppose any external movement of the rotor.

Abstract: Ultraviolet systems and methods are described for capturing images depicting absorption or remittance of ultraviolet radiation (UVR). An example system includes a camera comprising a monochrome camera sensor that is configured to capture images, a radiation source that is configured to output a UVR waveband, a filter component that is configured to differentiate at least one of a UVA waveband and a UVB waveband of the UVR waveband, and a polarizer component that is configured to cross polarize each of the UVA waveband and the UVB waveband. Further, the camera is configured to capture an image depicting an UVA amount of UVA absorption or remittance as projected on a surface area and an UVB amount of UVB absorption or remittance as projected on the surface area.