Patents by Inventor Jonathan Mark Gleadle

Jonathan Mark Gleadle has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ASSAYS FOR MODULATORS OF ASPARAGINYL HYDROXYLASE
    Publication number: 20090286858
    Abstract: The present invention is directed to methods of identifying an agent which modulates hydroxylation of hypoxia inducible factor (HIF), comprising contacting a HIF asparagine hydroxylase and a test substance in the presence of a substrate of the hydroxylase under conditions in which asparagine in the substrate is hydroxylated in the absence of the test substance; and determining hydroxylation of the substrate.
    Type: Application
    Filed: April 30, 2009
    Publication date: November 19, 2009
    Applicant: ISIS INNOVATION LIMITED
    Inventors: Christopher William PUGH, Jonathan Mark GLEADLE, Peter John RATCLIFFE, Christopher Joseph SCHOFIELD, Luke Alexander MCNEILL
  • Assays for modulators of asparaginyl hydroxylase
    Patent number: 7544480
    Abstract: A method of identifying an agent which modulates hydroxylation of hypoxia inducible factor (HIF), comprises contacting a HIF asparagine hydroxylase and a test substance in the presence of a substrate of the hydroxylase under conditions in which asparagine in the substrate is hydroxylated in the absence of the test substance; and determining hydroxylation of the substrate. Preferably the substrate is a HIF polypeptide comprising HIF-1?, a fragment thereof comprising Asn 803 of HIF-1? or a peptide analogue of HIF-1? or fragment thereof comprising an asparagine equivalent to Asn 803 of HIF-1? and wherein hydroxylation of Asn 803 or of a said equivalent asparagine is determined.
    Type: Grant
    Filed: May 23, 2003
    Date of Patent: June 9, 2009
    Assignee: Isis Innovation Limited
    Inventors: Christopher William Pugh, Jonathan Mark Gleadle, Peter John Ratcliffe, Christopher Joseph Schofield, Luke Alexander McNeill