Abstract: The present disclosure provides methods and systems for detecting multiple different nucleotides in a sample. In particular, the disclosure provides for detection of multiple different nucleotides in a sample utilizing fewer detection moieties than the number of nucleotides being detected and/or fewer imaging events than the number of nucleotides being detected.

Abstract: The present invention relates to methods of imaging template hybridisation for estimating cluster numbers prior to solid phase amplification and sequencing. More particularly, an initial round of imaging is carried out at the single molecule template hybridisation stage which allows a general estimation of cluster numbers prior to clusters being formed. Amplification of the signal allows single molecule imaging to be carried out using standard sequencing imaging apparatus.

Abstract: An audio filtering and power extraction apparatus for filtering out audio signal and extracting power from a combined signal and direct-current power line, with an input configured to couple to a combined signal and direct-current power line, a filtering extractor system functionally coupled to the input, a DC sensing switch circuit, and a second order low-pass filter functionally coupled to the DC sensing switch circuit, the second order low-pass filter including, an inductor, a capacitor and resistor in series with each other, and an output functionally coupled to an output of the filtering extractor system and through which output extracted power is provided.

Abstract: The present disclosure relates to a data storage system, and processes and computer programs for such data storage system, for example including processing of: managing one or more metadata tree structures for storing data to one or more storage devices of the data storage system in units of blocks, each metadata tree structure including a root node pointing directly and/or indirectly to blocks, and a leaf tree level having one or more direct nodes pointing to blocks, and optionally including one or more intermediate tree levels having one or more indirect nodes pointing to indirect nodes and/or direct nodes of the respective metadata tree structure; maintaining the root node and/or nodes of at least one tree level of each of at least one metadata structure in a cache memory; and managing I/O access to data based on the one or more metadata structures, including obtaining the root node and/or nodes of the at least one tree level of the metadata structure maintained in the cache memory from the cache memory an

Abstract: The apparatus comprises a plurality of interfaces, each interface having an associated interface ID; and a hardware-side processing device including at least one programmable hardware-implemented chip configured to process request packets, which are received from host computers and relate to access requests to one or more file system managed by the apparatus, and to generate response packets for the processed request packets; wherein, for a request packet which is received from a first host computer, at least one programmable hardware-implemented chip is configured to: determine the client ID being associated with the first host computer, determine the interface ID being associated with the first interface, determine whether the determined client ID and interface ID represent a permitted ID set or a prohibited ID set, and refrain from processing the received request packet if the determined client ID and interface ID represent a prohibited ID set.

Abstract: The present disclosure relates to a data storage system, and processes and computer programs for such data storage system, for example including processing of: managing one or more metadata tree structures for storing data to one or more storage devices of the data storage system in units of blocks, each metadata tree structure including a root node pointing directly and/or indirectly to blocks, and a leaf tree level having one or more direct nodes pointing to blocks, and optionally including one or more intermediate tree levels having one or more indirect nodes pointing to indirect nodes and/or direct nodes of the respective metadata tree structure; maintaining the root node and/or nodes of at least one tree level of each of at least one metadata structure in a cache memory; and managing I/O access to data based on the one or more metadata structures, including obtaining the root node and/or nodes of the at least one tree level of the metadata structure maintained in the cache memory from the cache memory an

Abstract: The present disclosure relates to a data storage system, and processes and computer programs for such data storage system, for example including processing of: managing one or more metadata tree structures for storing data to one or more storage devices of the data storage system in units of blocks, each metadata tree structure including a root node pointing directly and/or indirectly to blocks, and a leaf tree level having one or more direct nodes pointing to blocks, and optionally including one or more intermediate tree levels having one or more indirect nodes pointing to indirect nodes and/or direct nodes of the respective metadata tree structure; maintaining the root node and/or nodes of at least one tree level of each of at least one metadata structure in a cache memory; and managing I/O access to data based on the one or more metadata structures.

Abstract: The present disclosure relates to a data storage system, and processes and computer programs for such data storage system, for example including processing of: managing one or more metadata tree structures for storing data to one or more storage devices of the data storage system in units of blocks, each metadata tree structure including a root node pointing directly and/or indirectly to blocks, and a leaf tree level having one or more direct nodes pointing to blocks, and optionally including one or more intermediate tree levels having one or more indirect nodes pointing to indirect nodes and/or direct nodes of the respective metadata tree structure; maintaining the root node and/or nodes of at least one tree level of each of at least one metadata structure in a cache memory; and managing I/O access to data based on the one or more metadata structures.

Abstract: The apparatus comprises a plurality of interfaces, each interface having an associated interface ID; and a hardware-side processing device including at least one programmable hardware-implemented chip configured to process request packets, which are received from host computers and relate to access requests to one or more file system managed by the apparatus, and to generate response packets for the processed request packets; wherein, for a request packet which is received from a first host computer, at least one programmable hardware-implemented chip is configured to: determine the client ID being associated with the first host computer, determine the interface ID being associated with the first interface, determine whether the determined client ID and interface ID represent a permitted ID set or a prohibited ID set, and refrain from processing the received request packet if the determined client ID and interface ID represent a prohibited ID set.