Abstract: Balloon catheters for delivery of prosthetic hear valves are provided. The balloon catheters are configured to deploy a prosthetic heart valve through inflation. The balloon catheters are further configured with one or more retention bumpers to reduce or prevent migration of the prosthetic heart valve during delivery. Balloon catheters described herein are configured with substantially incompressible retention bumpers that promote longitudinal inflation fluid flow.

Abstract: An expandable intervertebral cage includes vertically opposed superior and inferior plates and longitudinally opposed distal and proximal wedges disposed between the plates. The wedges define ramps that engage complimentary ramps of the superior and inferior plates to increase a vertical distance between the plates. An actuator is located between the plates, defines a central, longitudinal axis, and is coupled to the wedges such that, as the actuator rotates about the axis, at least one of the wedges moves longitudinally relative to the other, thereby increasing the vertical separation distance. At least one locking component is insertable within a receptacle at least partially defined by the proximal wedge and is configured to transition from an unlocked configuration, where the actuator is rotatable relative to the proximal wedge, to a locked configuration, where the actuator is rotationally affixed relative to the proximal wedge.

Abstract: Balloon catheters for delivery of prosthetic hear valves are provided. The balloon catheters are configured to deploy a prosthetic heart valve through inflation. The balloon catheters are further configured with one or more retention bumpers to reduce or prevent migration of the prosthetic heart valve during delivery. Balloon catheters described herein are configured with substantially incompressible retention bumpers that promote longitudinal inflation fluid flow.

Abstract: A method of forming a semiconductor device for improving an electrical connection. The semiconductor device includes a top metal layer. A protective dielectric layer is formed over the top metal layer. A sintering operation is performed while the top metal layer is covered by the protective dielectric layer. After the sintering operation, the protective dielectric layer is patterned to expose areas on the top metal layer for bond pads of the semiconductor device. A bond pad cap is formed on the top metal layer where exposed by the protective dielectric layer.

Abstract: A method of on-demand energy delivery to an active suspension system comprising an actuator body, hydraulic pump, electric motor, plurality of sensors, energy storage facility, and controller is provided. The method comprises disposing an active suspension system in a vehicle between a wheel mount and a vehicle body, detecting a wheel event requiring control of the active suspension; and sourcing energy from the energy storage facility and delivering it to the electric motor in response to the wheel event.

Abstract: A secure one-time programming undo system includes a component and a component configuration system. A one-time programming subsystem in the component configuration system provides the component with personality configuration information that configures the component to perform component operations, and performs a one-time programming operation that configures a component engine in the component to deny modification requests to modify the personality configuration information.

Abstract: A computing device includes an array of processing elements mutually connected to perform single instruction multiple data (SIMD) operations, memory cells connected to each processing element to store data related to the SIMD operations, and a cache connected to each processing element to cache data related to the SIMD operations. Caches of adjacent processing elements are connected. The same or another computing device includes rows of mutually connected processing elements to share data. The computing device further includes a row arithmetic logic unit (ALU) at each row of processing elements. The row ALU of a respective row is configured to perform an operation with processing elements of the respective row.

Abstract: An interface structure for detachably interfacing a surgical robot arm to a surgical instrument, the interface structure comprising: a base portion comprising a first surface for facing the surgical instrument and a second surface for facing the surgical robot arm; and a plurality of first fasteners supported by the base portion and protruding from the first surface, the plurality of first fasteners configured to engage the surgical instrument so as to retain the interface structure to the surgical instrument. The interface structure engages the surgical robot arm so as to retain the interface structure to the surgical robot arm, wherein the plurality of first fasteners and the remainder of the interface structure are shaped such that when the surgical instrument is detached from the surgical robot arm the interface structure is retained to the surgical robot arm.

Abstract: The invention provides a compound of formula (0): or a pharmaceutically acceptable salt, N-oxide or tautomer thereof; wherein: n is 1 or 2; X is CH or N; Y is selected from CH and C—F; Z is selected from C—Rz and N; R1 is selected from: -(Alk1)t-Cyc1; wherein t is 0 or 1; Optionally substituted C1-6 acyclic hydrocarbon groups R2 is selected from hydrogen; halogen; and C1-8 hydrocarbon groups optionally substituted with one or more fluorine atoms; R3 is hydrogen or a group L1-R7; R4 is selected from hydrogen; methoxy; and optionally substituted C1-3 alkyl; and R4a is selected from hydrogen and a C1-3 alkyl group; wherein Rz, Alk1, Cyc1, L1 and R7 are defined herein; provided that the compound is other than 6-benzyl-3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and 3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and salts and tautomers thereof.

Abstract: The present invention provides compounds useful for the treatment of narcolepsy or cataplexy in a subject in need thereof. Related pharmaceutical compositions and methods are also provided herein.

Abstract: The present disclosure provides pepper plants exhibiting resistance to Phytophthora capsici. Such plants may comprise novel introgressed chromosomal regions associated with disease resistance. In certain aspects, compositions, including novel polymorphic markers and methods for producing, breeding, identifying, and selecting plants or germplasm with a disease resistance phenotype are provided.

Abstract: The present disclosure provides methods of producing extracellular vesicles and methods of increasing extracellular vesicle production from producer cells, which exhibit a reduced gene and/or protein function in a cholesterol biosynthetic pathway. Also provided are cell compositions having a reduced gene and/or protein function in a cholesterol biosynthetic pathway. Reducing gene and/or protein function in a cholesterol biosynthetic pathway increases the yield and production of extracellular vesicles from the producer cells.

Abstract: The present disclosure provides compositions and method for controlling fouling in a process for cleaning a hydrocarbon gas. The methods may include adding an effective amount of a composition to a conduit including the hydrocarbon gas. The composition includes, for example, various components, additives, and/or solvents. The compositions and methods may also be used for controlling fouling of equipment used during a process for cleaning and compressing a hydrocarbon gas. The equipment may be selected from, for example, a slug catcher, a scrubber, a suction drum, a compressor, and any combination thereof.

Abstract: A vehicle panel includes channels, wherein a first channel includes a first wire capable and a second channel includes a second wire and each wire is capable of carrying at least one of power or a vehicle data signal. The panel also includes a connection point connectable to at least one of a battery or a vehicle computing system, wherein selection of connection between the vehicle computing system or battery to a given connection point provided to a given one of the first or second channels dictates whether the channel carries the vehicle data signal or power. Also, the panel includes holes connecting to the first wire and at least two of the holes connecting to the second wire allowing a connection probe to be inserted into a respective hole to connect to a wire included in a channel to which the hole connects.

Abstract: Provided are systems and methods for synthesizing novel views of complex scenes (e.g., outdoor scenes). In some implementations, the systems and methods can include or use machine-learned models that are capable of learning from unstructured and/or unconstrained collections of imagery such as, for example, “in the wild” photographs. In particular, example implementations of the present disclosure can learn a volumetric scene density and radiance represented by a machine-learned model such as one or more multilayer perceptrons (MLPs).

Abstract: An expandable intervertebral cage includes vertically opposed superior and inferior plates and longitudinally opposed distal and proximal wedges disposed between the plates. The wedges define ramps that engage complimentary ramps of the superior and inferior plates to increase a vertical distance between the plates. An actuator is located between the plates, defines a central, longitudinal axis, and is coupled to the wedges such that, as the actuator rotates about the axis, at least one of the wedges moves longitudinally relative to the other, thereby increasing the vertical separation distance. At least one locking component is insertable within a receptacle at least partially defined by the proximal wedge and is configured to transition from an unlocked configuration, where the actuator is rotatable relative to the proximal wedge, to a locked configuration, where the actuator is rotationally affixed relative to the proximal wedge.

Abstract: A method of on-demand energy delivery to an active suspension system comprising an actuator body, hydraulic pump, electric motor, plurality of sensors, energy storage facility, and controller is provided. The method comprises disposing an active suspension system in a vehicle between a wheel mount and a vehicle body, detecting a wheel event requiring control of the active suspension; and sourcing energy from the energy storage facility and delivering it to the electric motor in response to the wheel event.

Abstract: In some examples, systems, methods, and devices are described that generate contextual suggestions for patients. Generation of the contextual suggestions is triggered by certain events performed by a medical professional with respect to a patient (e.g., updating a patient record). The contextual suggestions are related to addressing health conditions of the patient and represent tasks or considerations which the medical professional should be made aware. The contextual suggestions are generated in a way that is considerate of patient context, medical professional context, and contexts of similar patients. The contextual suggestions can be presented to the medical professional for selection and execution.

Abstract: The present disclosure provides compositions and method for controlling fouling in a process for cleaning a hydrocarbon gas. The methods may include adding an effective amount of a composition to a conduit including the hydrocarbon gas. The composition includes an anti-foam compound and other components are optional, such as a solvent or additive. The compositions and methods may also be used for controlling fouling of equipment used during a process for cleaning and compressing a hydrocarbon gas. The equipment may be selected from, for example, a slug catcher, a scrubber, a suction drum, a compressor, and any combination thereof.

Abstract: The invention relates to novel compounds having the general formula Ic wherein R1, R2, R3, R8, R9, RX, A1, A2, W and n are as described herein, composition including the compounds and methods of using the compounds.