Abstract: The present invention provides engineered uridine phosphorylase (UP) enzymes, polypeptides having UP activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing UP enzymes are also provided. The present invention further provides compositions comprising the UP enzymes and methods of using the engineered UP enzymes. The present invention finds particular use in the production of pharmaceutical compounds.

Abstract: Systems and methods disclosed herein provide a geo-targeted online reservation system that ensures authenticity of customer devices requesting reservations by generating reservations only if threshold authentication conditions are satisfied. For example, a computing device registered with a server system receives inputs for requesting a reservation of a limited release product and for configuring the product. To authenticate the computing device, the server device transmits an electronic message to the computing device requesting the computing device to respond. A response to the message is one threshold authentication condition for generating the reservation. Upon determining that one or more threshold authentication conditions are satisfied, the server device generates a reservation for the product.

Abstract: The disclosed computer-implemented method may include systems for generating personalized avatar reactions during live video broadcasts. For example, the systems and methods described herein can access a social networking system user's profile to identify an avatar associated with the social networking system user. The systems and methods can generate an avatar reaction by modifying one or more features of the avatar based on a corresponding emoticon reaction. Once generated, the social networking system user can select the avatar reaction for addition to an ephemeral reaction stream associated with a live video broadcast. Various other methods, systems, and computer-readable media are also disclosed.

Abstract: In clinical documentation, mere documentation of a condition in a patient's records may not be enough. To be considered sufficiently documented, the patient's record needs to show that no documentation drop-offs (DDOs) have occurred over the course of the patient's stay. However, DDOs can be extremely difficult to detect. To solve this problem, the invention trains time-sensitive deep learning (DL) models on a per condition basis using actual and/or synthetic patient data. Utilizing an ontology, grouped concepts can be generated on the fly from real-time hospital data and used to generate time-series data that can then be analyzed by trained time-sensitive DL models to determine whether a DDO for a condition has occurred during the stay. Non-time-sensitive models can be used to detect all the conditions documented during the stay. Outcomes from the models can be compared to determine whether to notify a user that a DDO has occurred.

Abstract: It is disclosed herein that ssAAV and scAAV vectors of the same serotype administered by injection into the cerebrospinal fluid (CSF) via the intracerebroventricular (ICV) or intrathecal (cisternal or lumbar) route exhibit different cellular tropisms in the central nervous system. Thus, a subject can be treated by injection into the CSF of ssAAV or scAAV vector encoding a therapeutic protein, such as an ssAAV9 or scAAV9 vector. The therapeutic protein can be targeted to specific cells using these vectors. In some embodiments, scAAV9 is utilized to achieve superior transduction in the hippocampus, cerebellum and cerebral cortex where both neurons, particularly Purkinje neurons, and glial cells (such as astrocytes) are transduced. In other embodiments, ssAAV9 is utilized to minimize transduction of astrocytes. In further embodiments, an immunosuppressive agent is also administered to the subject.

Abstract: A wing lock and deployment apparatus for an air launched vehicle includes a driver acted on by a single linear actuation event. The disclosed wing lock and deployment apparatus is capable of unlocking deployable wings of an air launched vehicle, deploying deployable wings of the air launched vehicle from a stored position, and locking deployable wings of the air launched vehicle in a deployed position in sequential order with the one single linear actuation event.

Abstract: A fuel tank comprises an interior wall, a sump, and a baffle that comprises a center fitting, a full-length containment petal, a partial-length containment petal, a dump tube. The full-length containment petal comprises a full-length side edge, extending radially outward from the center fitting. The partial-length containment petal comprises a partial-length side edge, extending radially outward from the center fitting. The dump tube is connected to the sump. The full-length side edge of the full-length containment petal is longer than the partial-length side edge of the partial-length containment petal. All of the partial-length side edge of the partial-length containment petal is attached to a linear portion of the full-length side edge of the full-length containment petal.

Abstract: A polymer compound containing groups having the chemical structure: where NH2 is a primary amine, and R is not hydrogen, and a polymer backbone wherein two of the R groups are part of the polymer backbone. A method of synthesizing a polymer includes polymerizing amine-convertible monomers to produce a polymer, causing a deprotection reaction with the polymer to form an isocyanate, decomposing the isocyanate to form a polymer containing primary amines. A method to separate CO2 from other gases comprising using a sorbent containing a polymer compound having the structure: where NH2 is a primary amine, and R is not hydrogen, and a polymer backbone wherein two of the R groups are part of the polymer backbone.

Abstract: Embodiments as disclosed provide systems and methods that use a local authenticator within a domain to provide a credential to access a resource of the domain to a non-local requestor. When a request is received from a non-local requestor at the domain the non-local requestor can be authenticated based on the request. The local authenticator can then be accessed to obtain a credential. This credential may be the same type of credential provided to members of the domain when they authenticate using the local authenticator. The credential is provided to the non-local requestor so the non-local requestor can access the resource of the domain using the credential and authentication of the non-local requestor with respect to these accesses can be accomplished using the local domain authenticator and the credential.

Abstract: A system for delivering reduced pressure and irrigation fluid to a wound site. The system includes a primary pressure source for delivering reduced pressure through a first lumen, a secondary pressure source for delivering secondary pressure through a second lumen, and an irrigation fluid source. A valve system is operable to selectively couple the secondary pressure source to the second lumen for delivering the secondary pressure to a wound site and selectively couple the fluid source to the second lumen for delivering the irrigation fluid to the wound site.

Abstract: A canister connection system for a negative pressure wound therapy system. The canister connection system includes an attachment fixture removably connected to a pump unit. The attachment fixture includes a first engaging mechanism disposed adjacent its first end configured to engage a corresponding first engaging mechanism of the canister and a second engaging mechanism disposed adjacent its second end for engaging a corresponding second engaging mechanism of the canister for removably connecting the canister to the pump unit.

Abstract: A bridge for facilitating delivery of reduced pressure to a wound site of a patient includes a reduced pressure lumen configured to be fluidly coupled to a reduced pressure source, and a secondary pressure lumen configured to be fluidly coupled to a secondary pressure source at a first end and to the reduced pressure lumen at a second end, thereby facilitating flow of exudate removed from the wound site by the reduced pressure source using the secondary pressure source. The reduced pressure lumen or the secondary pressure lumen includes a skin contacting surface formed of a moisture permeable membrane comprising an air-impermeable film that allows moisture from the patient to transfer into the reduced pressure lumen or secondary pressure lumen through the moisture permeable membrane while maintaining reduced pressure at the wound site.

Abstract: A clinical documentation improvement (CDI) smart scoring method may include predicting, via per-condition diagnosis machine learning (ML) models and based on clinical evidence received by a system, a probability that a medical condition is under-documented and, via per-condition documentation ML models and based on documentation received by the system, a probability that a medical condition is over-documented. The under- and over-documentation scores are combined in view of special indicators and queryability factors, which can also be evaluated using ML query prediction models, to generate an initial CDI score. This CDI score can be further adjusted, if necessary or desired, to account for factors such as length of stay, payer, patient location, CDI review timing, etc. The final CDI score can be used to prioritize patient cases for review by CDI specialists to quickly and efficiently identify meaningful CDI opportunities.

Abstract: Ablation systems of the present disclosure facilitate the safe formation of wide and deep lesions. For example, ablation systems of the present disclosure can allow for the flow of irrigation fluid and blood through an expandable ablation electrode, resulting in efficient and effective cooling of the ablation electrode as the ablation electrode delivers energy at a treatment site of the patient. Additionally, or alternatively, ablation systems of the present disclosure can include a deformable ablation electrode and a plurality of sensors that, in cooperation, sense the deformation of the ablation electrode, to provide a robust indication of the extent and direction of contact between the ablation electrode and tissue at a treatment site.

Abstract: A server system obtains a transcription of content from a video and applies a machine learning resource to identify entities which are most likely to be searched for by a user viewing the video, based on the transcription of the content. The server system generates entity cards for each of the entities, each of the entity cards including descriptive content relating to a respective entity among the entities. The server system provides a user interface, to be displayed on a respective display of one or more user computing devices, for playing the video on a first portion of the user interface. When the video is played and a first entity among the entities is mentioned in the video, the user interface displays a first entity card on a second portion of the user interface, the first entity card including descriptive content relating to the first entity.

Abstract: A refrigeration system including a storage chamber configured to store a product at a predetermined temperature. The storage chamber is defined by an inner wall. The inner wall at least partially defines an air plenum. The inner wall includes an opening wall surface, a floor surface, a rear wall surface and a ceiling wall surface. The system also includes a refrigerant circuit including a compressor, a condenser, a condenser fan, an evaporator and an evaporator fan arranged and disposed in an operable configuration to provide refrigeration to the storage chamber. The air plenum includes a conduit arranged and disposed to convey air from an air inlet across the evaporator and into a discharge chamber and out an air outlet. The air outlet is configured to discharge cooled air in a direction toward the opening wall surface.

Abstract: A negative pressure wound therapy system treats multiple wounds on a patient's body. The system includes a source of negative air pressure, an air source, first and second fluid collection volumes, first and second wound-covering domes disposed over first and second wounds, a valve assembly disposed between the source of negative air pressure and the first and second fluid collection volumes, and between the air source and the first and second domes. The valve assembly has first and second operational modes. In the first, the valve assembly puts the source of negative air pressure in fluid communication with the first fluid collection volume, and the air source in fluid communication with the first dome. In the second, the valve assembly puts the source of negative air pressure in fluid communication with the second fluid collection volume, and the air source in fluid communication with the second dome.

Abstract: A clinical documentation improvement (CDI) smart scoring method may include predicting, via per-condition diagnosis machine learning (ML) models and based on clinical evidence received by a system, a probability that a medical condition is under-documented and, via per-condition documentation ML models and based on documentation received by the system, a probability that a medical condition is over-documented. The under- and over-documentation scores are combined in view of special indicators and queryability factors, which can also be evaluated using ML query prediction models, to generate an initial CDI score. This CDI score can be further adjusted, if necessary or desired, to account for factors such as length of stay, payer, patient location, CDI review timing, etc. The final CDI score can be used to prioritize patient cases for review by CDI specialists to quickly and efficiently identify meaningful CDI opportunities.

Abstract: A negative pressure wound therapy device that includes a first tubing connectable in flow communication with a source of negative pressure configured for application of negative pressure to a wound site, a second tubing in flow communication with the wound site, and a valve.

Abstract: A support service application may process a request that contains a hyperlink. The hyperlink may be examined to determine a level of risk associated with accessing a resource referred to by the hyperlink. An execution environment for processing the hyperlink may be identified. The execution environment may comprise a virtual machine drawn from a pool of virtual machines. The resource may be retrieved by a browser process operating within the context of the virtual machine, and a safe version of the resource may be rendered and made available to customer support personnel using the support service application.