Patents by Inventor Jonathan Michael Tsai

Jonathan Michael Tsai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Isolation of unknown rearranged T-cell receptors from single cells
    Patent number: 8497071
    Abstract: Disclosed herein are methods and materials for isolating and identifying T cell receptors from single cells. In some embodiments, genomic DNA from a single T cell is isolated using whole genome amplification (WGA). A series of PCR reactions is carried out to enrich the genomic template for sequences encoding the TCR alpha and beta chains, and then to isolate the sequences encoding the TCR alpha and beta chains.
    Type: Grant
    Filed: June 28, 2010
    Date of Patent: July 30, 2013
    Assignee: California Institute of Technology
    Inventors: Alejandro Benjamin Balazs, Jonathan Michael Tsai, David Baltimore
  • ISOLATION OF UNKNOWN REARRANGED T-CELL RECEPTORS FROM SINGLE CELLS
    Publication number: 20110014659
    Abstract: Disclosed herein are methods and materials for isolating and identifying T cell receptors from single cells. In some embodiments, genomic DNA from a single T cell is isolated using whole genome amplification (WGA). A series of PCR reactions is carried out to enrich the genomic template for sequences encoding the TCR alpha and beta chains, and then to isolate the sequences encoding the TCR alpha and beta chains.
    Type: Application
    Filed: June 28, 2010
    Publication date: January 20, 2011
    Applicant: California Institute of Technology
    Inventors: Alejandro Benjamin Balazs, Jonathan Michael Tsai, David Baltimore