Abstract: The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, thereof: which inhibit the cellular entry of hepatitis B virus (HBV) and/or hepatitis D virus (HDV) or interfere with the function of the life cycle of HBV and/or HDV and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HBV and/or HDV infection. The invention also relates to methods of treating an HBV and/or HDV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

Abstract: An IV catheter system may have a catheter component and a needle component. The catheter component may have a catheter hub, a cannula extending distally from the catheter hub, and a push feature extending outward from the catheter hub. The push feature may have an outer surface that receives contact from a digit to move the IV catheter system from an insertion configuration, in which the needle is within the cannula, to a fluid delivery configuration, in which the needle is outside the catheter hub. The needle component may have a needle hub and a needle extending distally from the needle hub along an axis. The push feature may be formed of a flexible material that causes the push feature, in response to pressure exerted on the outer surface by a dressing securing the catheter component to a patient, to deflect the outer surface toward the cannula axis.

Abstract: The present invention provides engineered ketoreductase and phosphite dehydrogenase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase and phosphite dehydrogenase enzymes, as well as polynucleotides encoding the engineered ketoreductase and phosphite dehydrogenase enzymes, host cells capable of expressing the engineered ketoreductase and phosphite dehydrogenase enzymes, and methods of using the engineered ketoreductase and phosphite dehydrogenase enzymes to synthesize a chiral catalyst used in the synthesis of antiviral compounds, such as nucleoside inhibitors. The present invention further provides methods of using the engineered enzymes to deracemize a chiral alcohol in a one-pot, multi-enzyme system.

Abstract: Systems and methods of executing multiple scripts at an extension point are provided. If there are multiple scripts that are associated with an extension point for a service instance in a SAAS platform, a script execution schedule is determined. This can indicate the order of execution of the multiple scripts, but may also specify how the inputs and outputs of the multiple script executions are obtained. For example, the inputs for multiple scripts can be the same, and be those provided by the SAAS platform at the extension point. In this case, in effect the multiple scripts are executed independently. Alternatively, the output of one script can function as the input to another script, which requires a certain order of execution. After all of the scripts are executed, output rules are used to determine an overall output of the script execution to be returned the platform through the extension point.

Abstract: A digital neutron and photon track dosimeter based on three-dimensional Not-And (3D NAND) flash memory may be provided. A plurality of logical addresses respectively associated with a plurality of cells in a 3D NAND flash memory that have been flipped from a first charge state to a second charge state may be determined. Next, the plurality of logical addresses may be converted to a plurality of physical addresses associated with the plurality of cells in the 3D NAND flash memory that have been flipped from the first charge state to the second charge state by radiation. Then a radiation dose proportional to number and plurality of tracks within the plurality of cells associated with the plurality of physical address may be determined.

Abstract: Systems and methods of executing multiple scripts at an extension point are provided. If there are multiple scripts that are associated with an extension point for a service instance in a SAAS platform, a script execution schedule is determined. This can indicate the order of execution of the multiple scripts, but may also specify how the inputs and outputs of the multiple script executions are obtained. For example, the inputs for multiple scripts can be the same, and be those provided by the SAAS platform at the extension point. In this case, in effect the multiple scripts are executed independently. Alternatively, the output of one script can function as the input to another script, which requires a certain order of execution. After all of the scripts are executed, output rules are used to determine an overall output of the script execution to be returned the platform through the extension point.

Abstract: A method for measuring at least one property of a sample includes obtaining a sample of fluid including at least fines from a downhole environment, exposing the sample to a magnetic field, measuring a magnetic susceptibility of the fines in the sample in response to the magnetic field, and identifying at least one mineral present in the fines based at least partially on the magnetic susceptibility.

Abstract: Disclosed herein are system, method, and computer program product embodiments for localizing three-dimensional objects relative to a vehicle. The system includes: at least one sensor for generating two-dimensional (2D) data and a three-dimensional (3D) point cloud of an environment external to a vehicle. The 3D point cloud includes object points associated with a stationary traffic control object. The localization system also includes a memory and at least one processor coupled to the memory. The processor is programmed to: select a bounding box associated with the object from the memory based on the 2D data; arrange the bounding box proximate to the object points in the 3D point cloud; assign a weight to each point of the 3D point cloud based on a position of the point relative to the bounding box; filter the weighted points; and generate a 3D location of the object based on the filtered points.

Abstract: A battery system includes a power bus and a set of battery packs. A battery pack is one or more batteries, a sensor board, and a power board. The power bus is used to electrically connect the set of battery packs. The sensor board receives a voltage difference between a battery pack not connected to the power bus and the power bus; determines whether the voltage difference indicates that a battery pack voltage is too high compared to a power bus voltage; in response to determining the voltage difference indicates that the battery pack voltage is too high compared to the power bus voltage, provides a drain indication to drain off the battery pack using a power draw mechanism until the voltage of the battery pack is within a threshold voltage difference of the power bus; and provides a connect indication to connect the disconnected battery pack to the power bus.

Abstract: Tools and methods are used to determine the oil, water, and solids volume fractions in a drilling fluid at the rig site. The volume fractions can be determined in-line with returned drilling fluid by using an NMR magnet and a flow line or sample chamber that receives a fluid sample and loads it into the NMR magnet. Using an RF probe, spectrometer, and computing device, data processing and interpretation of NMR data from the spectrometer is performed, while also raising a flag when iron contamination exceeds a predefined threshold.

Abstract: Systems and methods of executing multiple scripts at an extension point are provided. If there are multiple scripts that are associated with an extension point for a service instance in a SAAS platform, a script execution schedule is determined. This can indicate the order of execution of the multiple scripts, but may also specify how the inputs and outputs of the multiple script executions are obtained. For example, the inputs for multiple scripts can be the same, and be those provided by the SAAS platform at the extension point. In this case, in effect the multiple scripts are executed independently. Alternatively, the output of one script can function as the input to another script, which requires a certain order of execution. After all of the scripts are executed, output rules are used to determine an overall output of the script execution to be returned the platform through the extension point.

Abstract: The provided systems and methods attempt to address possible issues with the use of third party applications with software as a service (SAAS) platforms, namely that lack of performance of third party app hosting infrastructure running the third party applications can affect multiple clients on the SAAS platform. In order to least mitigate this, third party app providers can create and upload their scripts to the SAAS platform for execution on the SAAS platform. The scripts must conform with extension points within SAAS functionality that are predefined. During execution, when the extension point is reached, the script is run on the SAAS platform instead of making an API call to the application on the third party app hosting infrastructure.

Abstract: Embodiments provide slide navigation technology that addresses challenges in digital pathology of navigating and viewing high resolution slide images. Example systems comprise a virtual slide stage (VSS) having at least one sensor that detects user movement of a target placed on the VSS, and an input component, coupled to the VSS, which provides quick function movement control of the target via quick functions. The systems also comprise a connector component that connects the VSS to a user device and transmits output from the at least one sensor and input component to the user device. The systems further comprise a computer processor, in communication with the VSS, which processes the output using a computational model to generate data representing movement profiles of the target. The computer processor executes a software component, causing the output, translated based on the movement profiles, to be relayed via a viewing application on the user device.

Abstract: A battery system includes a power bus and a set of battery packs. A battery pack is one or more batteries, a sensor board, and a power board. The power bus is used to electrically connect the set of battery packs. The sensor board receives a voltage difference between a battery pack not connected to the power bus and the power bus; determines whether the voltage difference indicates that a battery pack voltage is too high compared to a power bus voltage; in response to determining the voltage difference indicates that the battery pack voltage is too high compared to the power bus voltage, provides a drain indication to drain off the battery pack using a power draw mechanism until the voltage of the battery pack is within a threshold voltage difference of the power bus; and provides a connect indication to connect the disconnected battery pack to the power bus.

Abstract: The provided systems and methods attempt to address possible issues with the use of third party applications with software as a service (SAAS) platforms, namely that lack of performance of third party app hosting infrastructure running the third party applications can affect multiple clients on the SAAS platform. In order to least mitigate this, third party app providers can create and upload their scripts to the SAAS platform for execution on the SAAS platform. The scripts must conform with extension points within SAAS functionality that are predefined. During execution, when the extension point is reached, the script is run on the SAAS platform instead of making an API call to the application on the third party app hosting infrastructure.

Abstract: Embodiments provide slide navigation technology that addresses challenges in digital pathology of navigating and viewing high resolution slide images. Example systems comprise a virtual slide stage (VSS) having at least one sensor that detects user movement of a target placed on the VSS, and an input component, coupled to the VSS, which provides quick function movement control of the target via quick functions. The systems also comprise a connector component that connects the VSS to a user device and transmits output from the at least one sensor and input component to the user device. The systems further comprise a computer processor, in communication with the VSS, which processes the output using a computational model to generate data representing movement profiles of the target. The computer processor executes a software component, causing the output, translated based on the movement profiles, to be relayed via a viewing application on the user device.

Abstract: Methods for improved interpretation of NMR data acquired from industrial samples by simultaneously detecting more than one resonant nucleus without removing the sample from the sensitive volume of the NMR magnet or radio frequency probe are disclosed. In other aspects, the present disclosure provides methods for robust imaging/analysis of spatial distribution of different fluids (e.g., 1H, 23Na, 19F) within a core or reservoir rock. NMR data may be interpreted in real-time during dynamic processes to enable rapid screening, e.g. of enhanced oil recovery techniques and products and/or to provide improved interpretation of well-logs. Measurements of resonant nuclei other than 1H may be performed in the laboratory or downhole with a NMR logging tool. In other aspects, the present disclosure describes a novel kernel function to extract values for underlying parameters that define relaxation time behavior of a quadrupolar nucleus.

Abstract: A porous material with liquid in the pores is examined by submerging the material in a bathing liquid, possibly a perfluorocarbon, which is immiscible with the liquid in the pores, is non-wetting towards the material, is immiscible with and differs in density from any liquid on the outside of the material, and does not contain a resonant element found in the bathing liquid. This bathing liquid displaces fluid from the surface of the porous material but not the liquid in the pores. Nuclear magnetic resonance signals from liquid in the pores give a measurement of pore volume. Volume of bathing liquid displaced by the porous material gives the bulk volume and porosity can be derived from these measurements. Sample preparation is minimal and a benchtop spectrometer can be used, making the method practical for examination of drill cuttings from a borehole while drilling.

Abstract: Embodiments provide slide navigation technology that addresses challenges in digital pathology of navigating and viewing high resolution slide images. Example systems comprise a virtual slide stage (VSS) having at least one sensor that detects user movement of a target placed on the VSS, and an input component, coupled to the VSS, which provides quick function movement control of the target via quick functions. The systems also comprise a connector component that connects the VSS to a user device and transmits output from the at least one sensor and input component to the user device. The systems further comprise a computer processor, in communication with the VSS, which processes the output using a computational model to generate data representing movement profiles of the target. The computer processor executes a software component, causing the output, translated based on the movement profiles, to be relayed via a viewing application on the user device.

Abstract: A porous material with liquid in the pores is examined by submerging the material in a bathing liquid, possibly a perfluorocarbon, which is immiscible with the liquid in the pores, is non-wetting towards the material, is immiscible with and differs in density from any liquid on the outside of the material, and does not contain a resonant element found in the bathing liquid. This bathing liquid displaces fluid from the surface of the porous material but not the liquid in the pores. Nuclear magnetic resonance signals from liquid in the pores give a measurement of pore volume. Volume of bathing liquid displaced by the porous material gives the bulk volume and porosity can be derived from these measurements. Sample preparation is minimal and a benchtop spectrometer can be used, making the method practical for examination of drill cuttings from a borehole while drilling.