Patents by Inventor Jonathan MONTELEONE

Jonathan MONTELEONE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ALKALINE PHOSPHATASE POLYPEPTIDES AND METHODS OF USE THEREOF
    Publication number: 20240382568
    Abstract: Featured are pharmaceutical compositions that include a soluble alkaline phosphatase for treating bone mineralization disorders, such as hypophosphatasia (HPP), and symptoms thereof. The polypeptides include a soluble alkaline phosphatase (sALP) or fragment thereof, which is derived from a naturally occurring alkaline phosphatase (ALP).
    Type: Application
    Filed: August 7, 2024
    Publication date: November 21, 2024
    Inventors: Walter C. VOEGTLI, Yuhong WU, Jonathan MONTELEONE, Tatyana MEZHEBOVSKY, Eric FALCONE, Yang GUO
  • Alkaline phosphatase polypeptides and methods of use thereof
    Patent number: 12083169
    Abstract: Featured are pharmaceutical compositions that include a soluble alkaline phosphatase for treating bone mineralization disorders, such as hypophosphatasia (HPP), and symptoms thereof. The polypeptides include a soluble alkaline phosphatase (sALP) or fragment thereof, which is derived from a naturally occurring alkaline phosphatase (ALP).
    Type: Grant
    Filed: February 10, 2022
    Date of Patent: September 10, 2024
    Assignee: Alexion Pharmaceuticals, Inc.
    Inventors: Walter C. Voegtli, Yuhong Wu, Jonathan Monteleone, Tatyana Mezhebovsky, Eric Falcone, Yang Guo
  • DOSAGE AND ADMINISTRATION OF ANTI-C5 ANTIBODIES FOR TREATING HEMATOPOIETIC STEM CELL TRANSPLANT-ASSOCIATED THROMBOTIC MICROANGIOPATHY (HSCT-TMA)
    Publication number: 20240209071
    Abstract: Provided are methods for clinical treatment of hematopoietic stem cell transplant-associated thrombotic microangiopathy (HSCT-TMA), e.g., TMA after HSCT, in human patients using an anti-C5 antibody, or antigen binding fragment thereof.
    Type: Application
    Filed: August 12, 2021
    Publication date: June 27, 2024
    Applicant: Alexion Pharmaceuticals, Inc.
    Inventors: Stephan Ortiz, Jonathan Monteleone
  • METHODS FOR TREATING A COMPLEMENT MEDIATED DISORDER CAUSED BY VIRUSES
    Publication number: 20230416344
    Abstract: The present disclosure relates to, inter alia, a method of treating a complement mediated disorder caused by a virus, e.g., corona virus; Dengue virus (DENY); Ross River vims (RRV) and/or influenza virus (flu) by administering an effective amount of a complement modulator, such as, e.g., C5 inhibitor, such as eculizumab or an eculizumab variant or a C5a inhibitor such as olendalizumab (ALXN1007) or a variant thereof, to the subject. In addition, the present disclosure relates to, inter alia, a method of treating human patients inflicted with severe coronavirus disease-2019 (severe COVID-19) who is undergoing treatment with eculizumab. The method includes measuring a level of circulating component C5b-9 (membrane attack complex), in the patient's blood sample to titrate an effective eculizumab dose for the treatment of COVID-19.
    Type: Application
    Filed: April 16, 2021
    Publication date: December 28, 2023
    Inventors: Sharon Barr, Derek Dunn, Xiang Gao, Shamsah D. Kazani, Michele Mercuri, Jonathan Monteleone, Stephan Ortiz, Scott T. Rottinghaus, Martine Zimmermann, Djillali Annane, Veronique Fremeaux-Bacchi, Regis Peffault De Latour
  • ALKALINE PHOSPHATASE POLYPEPTIDES AND METHODS OF USE THEREOF
    Publication number: 20220265784
    Abstract: Featured are pharmaceutical compositions that include a soluble alkaline phosphatase for treating bone mineralization disorders, such as hypophosphatasia (HPP), and symptoms thereof. The polypeptides include a soluble alkaline phosphatase (sALP) or fragment thereof, which is derived from a naturally occurring alkaline phosphatase (ALP).
    Type: Application
    Filed: February 10, 2022
    Publication date: August 25, 2022
    Inventors: Walter C. VOEGTLI, Yuhong WU, Jonathan MONTELEONE, Tatyana MEZHEBOVSKY, Eric FALCONE, Yang GUO