Patents by Inventor Jonathan N. Sachs

Jonathan N. Sachs has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTI-DR5 POLYPEPTIDES AND METHODS OF USE THEREOF
    Publication number: 20230312737
    Abstract: Certain embodiments of the invention provide helix sequences that have affinity for Death Receptor 5 (DR5). Certain embodiments of the invention provide an isolated anti-DR5 polypeptide (e.g., affibody for DR5) that modulates the activity and/or conformation of DR5. Certain embodiments of the invention provide methods of noncompetitively inhibiting DR5 and/or treating a fatty liver disorder.
    Type: Application
    Filed: March 3, 2021
    Publication date: October 5, 2023
    Applicant: Regents of the University of Minnesota
    Inventors: Benjamin HACKEL, Jonathan N. SACHS, Nagamani VUNNAM
  • Methods to identify modulators of tau protein structure
    Patent number: 11726081
    Abstract: The present disclosure provides methods for identifying compounds that cause structural changes in tau protein monomer and oligomer conformation. The methods include the use of cells that include tau proteins labeled with one or more chromophores, and exposing the cells to a test compound. The method further includes detecting a change in fluorescence resonance energy transfer (FRET) between the chromophores.
    Type: Grant
    Filed: February 13, 2020
    Date of Patent: August 15, 2023
    Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Jonathan N. Sachs, Chih Hung Lo
  • NON-FIBRILLAR HEMOGLOBIN S OLIGOMERS AND METHODS TO IDENTIFY MODULATORS OF HEMOGLOBIN S POLYMERIZATION
    Publication number: 20230095509
    Abstract: Provided herein are deoxygenated sickle hemoglobin (HbS), at concentrations far below the threshold for nucleation and rapid polymerization, that form small temporally stable assemblies of multiple ?2?2 tetramers. Also provided are methods for making and detecting the small temporally stable assemblies and methods for identifying compounds that alter the structure of the small temporally stable assemblies.
    Type: Application
    Filed: September 27, 2022
    Publication date: March 30, 2023
    Inventors: David Kevin Wood, Jonathan N. Sachs, Nagamani Vunnam, Chih Hung Lo
  • METHODS TO IDENTIFY MODULATORS OF TAU PROTEIN STRUCTURE
    Publication number: 20200264162
    Abstract: The present disclosure provides methods for identifying compounds that cause structural changes in tau protein monomer and oligomer conformation. The methods include the use of cells that include tau proteins labeled with one or more chromophores, and exposing the cells to a test compound. The method further includes detecting a change in fluorescence resonance energy transfer (FRET) between the chromophores.
    Type: Application
    Filed: February 13, 2020
    Publication date: August 20, 2020
    Inventors: Jonathan N. Sachs, Chih Hung Lo