Abstract: A portable pathogen detection system that accomplishes on-site multiplex detection of targets in biological samples. The system includes: microbead specific reagents, incubation/mixing chambers, a disposable microbead capture substrate, and an optical measurement and decoding arrangement. The basis of this system is a highly flexible Liquid Array that utilizes optically encoded microbeads as the templates for biological assays. Target biological samples are optically labeled and captured on the microbeads, which are in turn captured on an ordered array or disordered array disposable capture substrate and then optically read.

Abstract: The optical fiber tap establishes optical communication between a branch optical fiber and a main optical fiber and includes a housing, a serpentine main channel and a branch channel. The main channel is defined in the housing and is shaped to accommodate part of the main optical fiber. The main channel includes a coupling curve portion shaped to define a main coupling curve in the main optical fiber. The branch channel is also defined in the housing and is shaped to accommodate part of the branch optical fiber. The branch channel communicates with the main channel at the coupling curve portion of the main channel. Optical signals couple laterally between the main optical fiber located in the main channel and the branch optical fiber located in the branch channel. Optical communication between the optical fibers is therefore established.

Abstract: A method is disclosed by which precision alignment of optical fiber to wave-guide or other optical elements can be carried out with an adjustable microstructure in active alignment mode fiber attachment. A microstructure containing three elongated U-grooves can be combined effectively to produce a movable and adjustable V-groove structure, which can be used to achieve sub-micron scale alignment control with zero rotational torque. This device not only makes fiber alignment easy and fast but also maintains the fiber attachment position after alignment and epoxy bonding. Multiple fiber array alignment can be carried out with only a global alignment of two end fibers.

Abstract: A method is disclosed by which precision alignment of optical fiber to wave-guide or other optical elements can be carried out with an adjustable microstructure in active alignment mode fiber attachment. A microstructure containing three elongated U-grooves can be combined effectively to produce a movable and adjustable V-groove structure, which can be used to achieve sub-micron scale alignment control with zero rotational torque. This device not only makes fiber alignment easy and fast but also maintains the fiber attachment position after alignment and epoxy bonding. Multiple fiber array alignment can be carried out with only a global alignment of two end fibers.

Abstract: The combined optical and electrical transmission line includes an optical fiber and an electrically-conductive sleeve that surrounds the optical fiber. The optical fiber transmits optical signals and the conductive sleeve conducts electrical signals or electrical power. The electrically-conductive sleeve may form part of an electrical transmission line having a characteristic impedance capable of transmitting a high-frequency electrical signal.

Abstract: A micro-optics device and a method for fabricating the micro-optics device is provided using one or more layers of an optically-transparent polymer resist having a viscosity between 2,000 and 100,000 centipoise or that is otherwise sufficient to allow stacking of one or more layers of the resist at a thickness of at least 10 microns per layer of resist. Each layer of the polymer resist is deposited onto a substrate and defined photolithographically to build a discrete relief structure upon which a final smoothing layer of polymer resist can be applied.

Abstract: The optical fiber tap establishes optical communication between a branch optical fiber and a main optical fiber and includes a housing, a serpentine main channel and a branch channel. The main channel is defined in the housing and is shaped to accommodate part of the main optical fiber. The main channel includes a coupling curve portion shaped to define a main coupling curve in the main optical fiber. The branch channel is also defined in the housing and is shaped to accommodate part of the branch optical fiber. The branch channel communicates with the main channel at the coupling curve portion of the main channel. Optical signals couple laterally between the main optical fiber located in the main channel and the branch optical fiber located in the branch channel. Optical communication between the optical fibers is therefore established.

Abstract: A portable pathogen detection system that accomplishes on-site multiplex detection of targets in biological samples. The system includes: microbead specific reagents, incubation/mixing chambers, a disposable microbead capture substrate, and an optical measurement and decoding arrangement. The basis of this system is a highly flexible Liquid Array that utilizes optically encoded microbeads as the templates for biological assays. Target biological samples are optically labeled and captured on the microbeads, which are in turn captured on an ordered array or disordered array disposable capture substrate and then optically read.

Abstract: A portable pathogen detection system that accomplishes on-site multiplex detection of targets in biological samples. The system includes: microbead specific reagents, incubation/mixing chambers, a disposable microbead capture substrate, and an optical measurement and decoding arrangement. The basis of this system is a highly flexible Liquid Array that utilizes optically encoded microbeads as the templates for biological assays. Target biological samples are optically labeled and captured on the microbeads, which are in turn captured on an ordered array or disordered array disposable capture substrate and then optically read.

Abstract: An apparatus and method for the collection of respirable particles and concentration of such particles into a small fluid volume. The apparatus captures and concentrates small (1-10 &mgr;m) respirable particles into a sub-millileter volume of fluid. The method involves a two step operation, collection and concentration: wherein collection of particles is by a wetted surface having small vertical slits that act as capillary channels; and concentration is carried out by transfer of the collected particles to a small volume (sub-milliliter) container by centrifugal force whereby the particles are forced through the vertical slits and contact a non-wetted wall surface, and are deflected to the bottom where they are contained for analysis, such as a portable flow cytometer or a portable PCR DNA analysis system.