Patents by Inventor Jonathan N. Webb

Jonathan N. Webb has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for protein refolding
    Patent number: 8329878
    Abstract: The present invention discloses improved methods of disaggregating protein aggregates, and refolding denatured proteins, using high pressure. In particular, the present invention provides for the use of agitation, high temperature, “stepped” depressurization, dialysis and dilution under pressure to increase the speed and extent of aggregate dissolution and protein refolding.
    Type: Grant
    Filed: April 17, 2009
    Date of Patent: December 11, 2012
    Assignee: Barofold Inc.
    Inventors: Theodore W. Randolph, John F. Carpenter, Richard J. St. John, Jonathan N. Webb
  • METHODS FOR PROTEIN REFOLDING
    Publication number: 20100075399
    Abstract: The present invention discloses improved methods of disaggregating protein aggregates, and refolding denatured proteins, using high pressure. In particular, the present invention provides for the use of agitation, high temperature, “stepped” depressurization, dialysis and dilution under pressure to increase the speed and extent of aggregate dissolution and protein refolding.
    Type: Application
    Filed: April 17, 2009
    Publication date: March 25, 2010
    Inventors: Theodore W. RANDOLPH, John F. Carpenter, Richard J. St. John, Jonathan N. Webb
  • Methods for protein refolding
    Patent number: 7538198
    Abstract: The present invention discloses improved methods of disaggregating protein aggregates, and refolding denatured proteins, using high pressure. In particular, the present invention provides for the use of agitation, high temperature, “stepped” depressurization, dialysis and dilution under pressure to increase the speed and extent of aggregate dissolution and protein refolding.
    Type: Grant
    Filed: April 29, 2003
    Date of Patent: May 26, 2009
    Assignee: Barofold, Inc.
    Inventors: Theodore W. Randolph, John F. Carpenter, Richard J. St. John, Jonathan N. Webb
  • Scaled down freezing and thawing system for biopharmaceuticals and biologics
    Patent number: 7228688
    Abstract: A freezing and thawing unit for small amounts of biopharmaceuticals and biologics. The freezing and thawing unit is reduced in scale, as compared to a corresponding commercial or large-scale process. The freezing and thawing unit can be used for testing, preservation and/or processing of small quantities of biopharmaceuticals and biologics.
    Type: Grant
    Filed: December 12, 2003
    Date of Patent: June 12, 2007
    Assignee: Integrated Biosystems, Inc.
    Inventors: Nicolas Voute, Richard Wisniewski, Eric K. Lee, Jonathan N. Webb
  • Scaled down freezing and thawing system for biopharmaceuticals and biologics
    Publication number: 20040139753
    Abstract: A freezing and thawing unit for small amounts of biopharmaceuticals and biologics. The freezing and thawing unit is reduced in scale, as compared to a corresponding commercial or large-scale process. The freezing and thawing unit can be used for testing, preservation and/or processing of small quantities of biopharmaceuticals and biologics.
    Type: Application
    Filed: December 12, 2003
    Publication date: July 22, 2004
    Applicant: Integrated Biosystems, Inc.
    Inventors: Nicolas Voute, Richard Wisniewski, Eric K. Lee, Jonathan N. Webb
  • Methods for protein refolding
    Publication number: 20040038333
    Abstract: The present invention discloses improved methods of disaggregating protein aggregates, and refolding denatured proteins, using high pressure. In particular, the present invention provides for the use of agitation, high temperature, “stepped” depressurization, dialysis and dilution under pressure to increase the speed and extent of aggregate dissolution and protein refolding.
    Type: Application
    Filed: April 26, 2003
    Publication date: February 26, 2004
    Inventors: Theodore W. Randolph, John F. Carpenter, Richard J. St.John, Jonathan N. Webb
  • Method of substantially reducing hazardous pathogens on the surface of food products
    Patent number: 5514403
    Abstract: This invention is a method of substantially reducing and in some cases eliminating hazardous pathogens form the surfaces of food products. This is accomplished by moving the meat products into a treatment area and spraying the same with super heated steam preferably heated to between 250 and 300 degrees Fahrenheit for a period of 1 to 5 seconds depending on the food product being treated. The surfaces of the food products are then immediately cooled by applying a chilled fluid having a temperature of between 35 and 40 degrees Fahrenheit for a period of 5 to 10 seconds. Even though the super heated steam substantially reduces or eliminates hazardous pathogens on the surface of the food products, the cooling fluid allows such surface to maintain its natural color or bloom.
    Type: Grant
    Filed: October 4, 1994
    Date of Patent: May 7, 1996
    Inventors: Neil B. Webb, Jonathan N. Webb, Wayne P. Pruett, Jr.