Abstract: A histotripsy therapy system configured for the treatment of tissue is provided, which may include any number of features. Provided herein are systems and methods that provide efficacious non-invasive and minimally invasive therapeutic, diagnostic and research procedures. In particular, provided herein are optimized systems and methods that provide targeted, efficacious histotripsy in a variety of different regions and under a variety of different conditions without causing undesired tissue damage to intervening/non-target tissues or structures.

Abstract: A histotripsy therapy system configured for the treatment of tissue is provided, which may include any number of features. Provided herein are systems and methods that provide efficacious non-invasive and minimally invasive therapeutic, diagnostic and research procedures. In particular, provided herein are optimized systems and methods that provide targeted, efficacious histotripsy in a variety of different regions and under a variety of different conditions without causing undesired tissue damage to intervening/non-target tissues or structures.

Abstract: A system and method, including an ultrasound imaging transducer, an ultrasound therapy transducer, a robotic arm configured to orient the ultrasound imaging transducer and the ultrasound therapy transducer about a patient, a display connected to imaging transducer, and a memory, storing instructions that when executed by a processor receive ultrasound images from the imaging transducer, present ultrasound images, receive an input to alter a shape of a contour line, present the contour line, receive an input of a size of a margin around the treatment area, present the margin, determine end points at locations where X, Y, and Z axes bisect the contour line in an XZ plane and a YZ plane, drive the ultrasound therapy transducer to a location where a focal point of the ultrasound therapy transducer is at the end point, and determining whether a resistance to movement exceeds a threshold.

Abstract: A method for interpreting incident reports parses an incident report. The method determines abnormal condition scores, each abnormal condition score corresponding to at least one parsed word of the incident report. The method determines normal condition scores, each normal condition score corresponding to at least one parsed word of the incident report. The method generates a user interface having a visual representation of the incident report. The method marks a set of parsed words corresponding to a portion of the abnormal condition scores using a first visual indicator. The method marks another set of parsed words corresponding to a portion of normal condition scores using a second visual indicator.

Abstract: A method for monitoring an industrial facility divides an incident report into text portions. The method determines text confidence values to the text portions. The method determines a report characteristic including a non-textual data type for the incident report. The method trains a neural network model. The method inputs the text confidence values and the report characteristic into the neural network model. The method outputs a network confidence value from the neural network model in response to inputting the text confidence values and the report characteristic.

Abstract: A histotripsy therapy system configured for the treatment of tissue is provided, which may include any number of features. Provided herein are systems and methods that provide efficacious non-invasive and minimally invasive therapeutic, diagnostic and research procedures. In particular, provided herein are optimized systems and methods that provide targeted, efficacious histotripsy in a variety of different regions and under a variety of different conditions without causing undesired tissue damage to intervening/non-target tissues or structures.

Abstract: Provided is a solid dispersion of (2R,3S,4S,5R)-4-[[3-(3,4-difluoro-2-methoxy-phenyl)-4,5-dimethyl-5-(trifluoromethyl) tetrahydrofuran-2-carbonyl]amino]pyridine-2-carboxamide (Compound 1), defined as described herein, or a pharmaceutically acceptable salt thereof and a tablet containing the solid dispersion for treating pain. Also disclosed herein is Compound 1 or a pharmaceutically acceptable salt thereof for use in a method of treating pain.

Abstract: A cable seal connector assembly includes an outer housing having a sealing area with a plurality of terminal insertion cavities configured to receive a wire and a cable seal of an electrical connection. The cable seal is disposed about the wire and configured to seal one terminal insertion cavity of the plurality of terminal insertion cavities. At least one terminal insertion cavity of the plurality of terminal insertion cavities includes a molded member integrally formed within the terminal insertion cavity when the outer housing is formed. The molded member is configured to seal the terminal insertion cavity, and the molded member configured to be removed from the terminal insertion cavity.

Abstract: A cable seal connector assembly includes an outer housing having a sealing area with a plurality of terminal insertion cavities configured to receive a wire and a cable seal of an electrical connection. The cable seal is disposed about the wire and configured to seal one terminal insertion cavity of the plurality of terminal insertion cavities. At least one terminal insertion cavity of the plurality of terminal insertion cavities includes a molded member integrally formed within the terminal insertion cavity when the outer housing is formed. The molded member is configured to seal the terminal insertion cavity, and the molded member configured to be removed from the terminal insertion cavity.

Abstract: A connector assembly that includes first and second connector housings, which are configured to hold a plurality of male terminals, a pair of lock tabs, which are disposed on opposite sides of the first connector housing, and a male terminal protector that is engaged to the lock tabs to protect ends of the male terminals that are to engage the female terminals when the second connector housing is fully mated to the first connector housing. The male terminal protector is released from the lock tabs when the second connector housing is positioned in a connector pre-set condition so that they do not impede movement of the male terminal protector when the second connector is moved toward the first connector housing to align and mate the female terminals with the male terminals.

Abstract: A connector assembly that includes first and second connector housings, which are configured to hold a plurality of male terminals, a pair of lock tabs, which are disposed on opposite sides of the first connector housing, and a male terminal protector that is engaged to the lock tabs to protect ends of the male terminals that are to engage the female terminals when the second connector housing is fully mated to the first connector housing. The male terminal protector is released from the lock tabs when the second connector housing is positioned in a connector pre-set condition so that they do not impede movement of the male terminal protector when the second connector is moved toward the first connector housing to align and mate the female terminals with the male terminals.