Abstract: Processes for producing layered components that may include depositing a strike layer on a substrate; forming a nanomaterial layer on the strike layer, the nanomaterial layer having a nanotextured surface comprising a plurality of nanofeatures; embedding a polymeric material at least partially within the nanotextured surface; and separating the strike layer from the substrate to obtain the layered component. Layered components that may include a nanomaterial layer having a nanotextured surface comprising a plurality of nanofeatures; and a polymeric material at least partially embedded within the nanotextured surface. Nanotextured polymeric materials and layered components produced by various processes.

Abstract: A method for simultaneous additive manufacturing and thickness-limited, electrospray deposition may include forming an electrically conductive target via additive manufacturing and exposing the electrically conductive target to an incident spray comprising a thermo-responsive polymer solution, in the presence of an electric field. The electrically conductive target may have a surface temperature, the thermo-responsive polymer solution may have a solution temperature, and the thermo-responsive polymer solution may include a non-conductive polymer. The method may further include allowing the solution temperature to deviate toward the surface temperature to a deposited temperature at which the non-conductive polymer is immobile. The method may further include allowing the non-conductive polymer to accumulate on the electrically conductive target to form a layer, having a thickness sufficient to repulse the incident spray.

Abstract: Method of preparing a porous material includes preparing a mixture of from about 10 to about 30% by mass of a matrix material, from about 20 to about 60% by mass of a plurality of particles, from about 20 to about 60% by mass of a porogen, and from about 1 to about 10% by mass of an interfacial compatibilizer. The matrix material and the porogen may be selected so as to be phase separated in the mixture. The method may further include placing the mixture into a form; initiating a solidification of the matrix material during which the porogen remains nonvolatile and the matrix material and the porogen remain phase separated; and removing at least a portion of the porogen to obtain the porous material. Porous materials produced by the methods. Microfluidic channels produced by the methods.

Abstract: A method and apparatus for promoting the delivery of a molecule across a cell membrane comprises delivering a molecule to a delivery site of a region of tissue surrounding the cell membrane. A suction component applies a suction through a suction tip that surrounds the surface of the delivery site creating a seal to promote delivery of the molecule across the cell membrane. The application of the suction is controlled to create a predetermined negative pressure for a predetermined period of time before releasing the negative pressure. Suction is used to enhance permeabilization and transfection of cells. The technique can be used to enhance the uptake and subsequent transfection and expression of plasmid DNA vaccines, mRNA vaccines and other nucleic acid molecules, that are introduced subcutaneously. It can be used in combination with coated microneedles.

Abstract: Self-limiting electrospray compositions including a non-charge-dissipative component and/or a charge-dissipative component. Self-limiting electrospray composition including a plurality of charge-dissipative components and excluding a non-charge-dissipative component. Methods for forming layers of self-limiting thickness. Methods for determining a conductivity of a material. Methods for repairing a flaw in a layer on a surface of an object.