Patents by Inventor Jonathan Pachter

Jonathan Pachter has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMBINATION THERAPY FOR TREATING ABNORMAL CELL GROWTH
    Publication number: 20240115571
    Abstract: The present invention relates to methods, compositions, and oral dosage forms of a SHP2 inhibitor, a SOS1 inhibitor, an ERK1/2 inhibitor, a CDK4/6 inhibitor, an AKT inhibitor, an mTOR inhibitor, a pan-HER inhibitor, or an EGFR inhibitor in combination with a MEK inhibitor or a dual RAF/MEK inhibitor, for treating abnormal cell growth (e.g., cancer).
    Type: Application
    Filed: February 4, 2022
    Publication date: April 11, 2024
    Inventors: Silvia COMA, Jonathan A. PACHTER, Sanjib CHOWDHURY
  • THERAPEUTIC COMPOSITIONS, COMBINATIONS, AND METHODS OF USE
    Publication number: 20240000790
    Abstract: This invention relates to methods comprising administering a FAK inhibitor and an immunotherapeutic agent such as anti-PD-1 or anti-PD-L1; that are useful in the treatment of abnormal cell growth, such as cancer, in mammals, especially humans.
    Type: Application
    Filed: December 21, 2022
    Publication date: January 4, 2024
    Inventors: Jonathan A. Pachter, Jennifer E. Ring, David T. Weaver, Yan Wang
  • COMBINATION THERAPY FOR TREATING ABNORMAL CELL GROWTH
    Publication number: 20230330088
    Abstract: The present invention relates to methods, compositions, and oral dosage forms of a dual RAF/MEK inhibitor in combination with an anti-PD-1 antibody or an anti-PD-L1 antibody for treating abnormal cell growth (e.g., cancer).
    Type: Application
    Filed: July 13, 2021
    Publication date: October 19, 2023
    Inventors: Silvia COMA, Jonathan A. PACHTER
  • METHODS AND COMPOSITIONS FOR TREATING ABNORMAL CELL GROWTH
    Publication number: 20230321097
    Abstract: The present invention relates to, inter alia, combinations, methods, compositions, and oral dosage forms of a FAK inhibitor and a MEK inhibitor, for treating abnormal cell growth (e.g., cancer).
    Type: Application
    Filed: November 17, 2022
    Publication date: October 12, 2023
    Inventors: Jonathan A. Pachter, Winnie Tam, Qunli Xu
  • TREATMENT OF CANCERS USING PI3 KINASE ISOFORM MODULATORS
    Publication number: 20230293534
    Abstract: Provided herein, at least in part, are methods of treating a hematologic malignancy in a human subject in need thereof, comprising orally administering to the subject duvelisib or a pharmaceutically acceptable form thereof.
    Type: Application
    Filed: July 24, 2020
    Publication date: September 21, 2023
    Inventors: Daniel PATERSON, Jonathan A. PACHTER, Hagop YOUSSOUFIAN, Stephanie LUSTGARTEN
  • METHODS OF TREATING ABNORMAL CELL GROWTH
    Publication number: 20230201198
    Abstract: The present invention relates to methods for treating abnormal cell growth (e.g., cancer) in a subject identified as having a KRAS mutation (e.g., KRAS G12X mutation (e.g., KRAS G12V, KRAS G12D, KRAS G12A, KRAS G12R, KRAS G12S, or KRAS G12C)) comprising administering to the subject an effective amount of a MEK inhibitor (e.g., a dual RAF/MEK inhibitor) alone or in combination with an additional agent.
    Type: Application
    Filed: April 27, 2021
    Publication date: June 29, 2023
    Inventors: Jonathan A. PACHTER, Daniel PATERSON, Brian M. STUGLIK
  • COMBINATION THERAPY FOR TREATING ABNORMAL CELL GROWTH
    Publication number: 20230103007
    Abstract: The present invention relates to methods, compositions, and oral dosage forms of a KRAS G12C inhibitor in combination with a FAK inhibitor and/or a MEK. inhibitor or a dual RAF/MEK inhibitor, for treating abnormal cell growth (e.g., cancer).
    Type: Application
    Filed: January 28, 2021
    Publication date: March 30, 2023
    Inventors: Jonathan A. PACHTER, Silvia COMA
  • Therapeutic compositions, combinations, and methods of use
    Patent number: 11564927
    Abstract: This invention relates to methods comprising administering a FAK inhibitor and an immunotherapeutic agent such as anti-PD-1 or anti-PD-L1; that are useful in the treatment of abnormal cell growth, such as cancer, in mammals, especially humans.
    Type: Grant
    Filed: November 25, 2019
    Date of Patent: January 31, 2023
    Assignee: Verastem, Inc.
    Inventors: Jonathan A. Pachter, Jennifer E. Ring, David T. Weaver, Yan Wang
  • METHODS OF MAKING CELLULAR THERAPIES
    Publication number: 20220387491
    Abstract: The present disclosure relates generally to methods of making immune effector cells, such as those engineered to express a Chimeric Antigen Receptor (CAR) including CAR-T cells, and compositions comprising the same, for use in treating cancer.
    Type: Application
    Filed: November 4, 2020
    Publication date: December 8, 2022
    Inventors: Jonathan A. PACHTER, Silvia COMA
  • COMBINATION THERAPIES
    Publication number: 20210338681
    Abstract: Provided herein are pharmaceutical compositions comprising a phosphatidylinositol 3-kinase inhibitor, or a pharmaceutically acceptable form thereof, in combination with a CD47 inhibitor, or a pharmaceutically acceptable form thereof in the presence or absence of an opsonizing antibody. Also provided herein are methods of treatment comprising administration of the compositions, and uses of the compositions, e.g., for treatment of cancer.
    Type: Application
    Filed: October 1, 2019
    Publication date: November 4, 2021
    Inventors: Jonathan A. PACHTER, Shawn LELAND
  • THERAPEUTIC COMPOSITIONS, COMBINATIONS, AND METHODS OF USE
    Publication number: 20200330471
    Abstract: This invention relates to methods comprising administering a FAK inhibitor and an immunotherapeutic agent such as anti-PD-1 or anti-PD-L1; that are useful in the treatment of abnormal cell growth, such as cancer, in mammals, especially humans.
    Type: Application
    Filed: November 25, 2019
    Publication date: October 22, 2020
    Inventors: Jonathan A. Pachter, Jennifer E. Ring, David T. Weaver, Yan Wang
  • METHODS AND COMPOSITIONS FOR TREATING ABNORMAL CELL GROWTH
    Publication number: 20200147080
    Abstract: The present invention relates to, inter alia, combinations, methods, compositions, and oral dosage forms of a FAK inhibitor and a MEK inhibitor, for treating abnormal cell growth (e.g., cancer).
    Type: Application
    Filed: July 23, 2019
    Publication date: May 14, 2020
    Inventors: Jonathan A. Pachter, Winnie Tam, Qunli Xu
  • Therapeutic compositions, combinations, and methods of use
    Patent number: 10532056
    Abstract: This invention relates to methods comprising administering a FAK inhibitor and an immunotherapeutic agent such as anti-PD-1 or anti-PD-L1; that are useful in the treatment of abnormal cell growth, such as cancer, in mammals, especially humans.
    Type: Grant
    Filed: June 29, 2016
    Date of Patent: January 14, 2020
    Assignee: Verastem, Inc.
    Inventors: Jonathan A. Pachter, Jennifer E. Ring, David T. Weaver, Yan Wang
  • Methods and compositions for treating abnormal cell growth
    Patent number: 10406158
    Abstract: The present invention relates to, inter alia, combinations, methods, compositions, and oral dosage forms of a FAK inhibitor and a MEK inhibitor, for treating abnormal cell growth (e.g., cancer).
    Type: Grant
    Filed: April 2, 2018
    Date of Patent: September 10, 2019
    Assignee: Verastem, Inc.
    Inventors: Jonathan A. Pachter, Winnie Tam, Qunli Xu
  • METHODS AND COMPOSITIONS FOR TREATING ABNORMAL CELL GROWTH
    Publication number: 20190046531
    Abstract: The present invention relates to, inter alia, combinations, methods, compositions, and oral dosage forms of a FAK inhibitor and a MEK inhibitor, for treating abnormal cell growth (e.g., cancer).
    Type: Application
    Filed: April 2, 2018
    Publication date: February 14, 2019
    Inventors: Jonathan A. Pachter, Winnie Tam, Qunli Xu
  • THERAPEUTIC COMPOSITIONS, COMBINATIONS, AND METHODS OF USE
    Publication number: 20180177788
    Abstract: This invention relates to methods comprising administering a FAK inhibitor and an immunotherapeutic agent such as anti-PD-1 or anti-PD-L1; that are useful in the treatment of abnormal cell growth, such as cancer, in mammals, especially humans.
    Type: Application
    Filed: June 29, 2016
    Publication date: June 28, 2018
    Inventors: Jonathan A. Pachter, Jennifer E. Ring, David T. Weaver, Yan Wang
  • Methods and compositions for treating abnormal cell growth
    Patent number: 9962385
    Abstract: The present invention relates to, inter alia, combinations, methods, compositions, and oral dosage forms of a FAK inhibitor and a MEK inhibitor, for treating abnormal cell growth (e.g., cancer).
    Type: Grant
    Filed: February 6, 2015
    Date of Patent: May 8, 2018
    Assignee: Verastem, Inc.
    Inventors: Jonathan A. Pachter, Winnie Tam, Qunli Xu
  • METHODS AND COMPOSITIONS FOR TREATING ABNORMAL CELL GROWTH
    Publication number: 20160346282
    Abstract: The present invention relates to, inter alia, combinations, methods, compositions, and oral dosage forms of a FAK inhibitor and a MEK inhibitor, for treating abnormal cell growth (e.g., cancer).
    Type: Application
    Filed: February 6, 2015
    Publication date: December 1, 2016
    Inventors: Jonathan A. Pachter, Winnie Tam, Qunli Xu
  • Methods and Compositions for Treating or Preventing Cancer
    Publication number: 20150093398
    Abstract: This invention relates to compositions and methods useful for treating various cancers. Therapeutic combinations and methods of use thereof are also covered in the present application.
    Type: Application
    Filed: September 16, 2014
    Publication date: April 2, 2015
    Inventors: YAOLIN WANG, MING LIU, YAN WANG, JONATHAN A. PACHTER, WALTER R. BISHOP
  • METHODS OF IDENTIFYING GENE ISOFORMS FOR ANTI-CANCER TREATMENTS
    Publication number: 20150071947
    Abstract: Novel methods of classifying subjects as candidates for treatment with agent that inhibits or kills cancer associated mesenchymal cells, tumor initiating cancer cells, or cancer stem cells treatment and subsequent administration of the agent that inhibits or kills cancer associated mesenchymal cells, tumor initiating cancer cells, or cancer stem cells are disclosed within.
    Type: Application
    Filed: March 8, 2013
    Publication date: March 12, 2015
    Inventors: David T. Weaver, Irina Shapiro, Daniel W. Paterson, Alan G. Derr, Jonathan A. Pachter