Patents by Inventor Jonathan Packer

Jonathan Packer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and systems for copy number variant detection
    Patent number: 11568957
    Abstract: Methods and systems for determining copy number variants are disclosed. An example method can comprise applying a sample grouping technique to select reference coverage data, normalizing sample coverage data comprising a plurality of genomic regions, and fitting a mixture model to the normalized sample coverage data based on the selected reference coverage data. An example method can comprise identifying one or more copy number variants (CNVs) according to a Hidden Markov Model (HMM) based on the normalized sample coverage data and the fitted mixture model. An example method can comprise outputting the one or more copy number variants.
    Type: Grant
    Filed: July 2, 2019
    Date of Patent: January 31, 2023
    Assignee: Regeneron Pharmaceuticals Inc.
    Inventors: Jeffrey Reid, Lukas Habegger, Jonathan Packer, Evan Maxwell
  • Methods And Systems For Copy Number Variant Detection
    Publication number: 20200035326
    Abstract: Methods and systems for determining copy number variants are disclosed. An example method can comprise applying a sample grouping technique to select reference coverage data, normalizing sample coverage data comprising a plurality of genomic regions, and fitting a mixture model to the normalized sample coverage data based on the selected reference coverage data. An example method can comprise identifying one or more copy number variants (CNVs) according to a Hidden Markov Model (HMM) based on the normalized sample coverage data and the fitted mixture model. An example method can comprise outputting the one or more copy number variants.
    Type: Application
    Filed: July 2, 2019
    Publication date: January 30, 2020
    Inventors: Jeffrey Reid, Lukas Habegger, Jonathan Packer, Evan Maxwell
  • Methods and systems for copy number variant detection
    Patent number: 10395759
    Abstract: Methods and systems for determining copy number variants are disclosed. An example method can comprise applying a sample grouping technique to select reference coverage data, normalizing sample coverage data comprising a plurality of genomic regions, and fitting a mixture model to the normalized sample coverage data based on the selected reference coverage data. An example method can comprise identifying one or more copy number variants (CNVs) according to a Hidden Markov Model (HMM) based on the normalized sample coverage data and the fitted mixture model. An example method can comprise outputting the one or more copy number variants.
    Type: Grant
    Filed: May 18, 2015
    Date of Patent: August 27, 2019
    Assignee: REGENERON PHARMACEUTICALS, INC.
    Inventors: Jeffrey Reid, Lukas Habegger, Jonathan Packer, Evan Maxwell
  • Methods And Systems For Copy Number Variant Detection
    Publication number: 20160342733
    Abstract: Methods and systems for determining copy number variants are disclosed. An example method can comprise applying a sample grouping technique to select reference coverage data, normalizing sample coverage data comprising a plurality of genomic regions, and fitting a mixture model to the normalized sample coverage data based on the selected reference coverage data. An example method can comprise identifying one or more copy number variants (CNVs) according to a Hidden Markov Model (HMM) based on the normalized sample coverage data and the fitted mixture model. An example method can comprise outputting the one or more copy number variants.
    Type: Application
    Filed: May 18, 2015
    Publication date: November 24, 2016
    Inventors: Jeffrey Reid, Lukas Habegger, Jonathan Packer, Evan Maxwell