Patents by Inventor Jonathan Patrick LOWTHER

Jonathan Patrick LOWTHER has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • T cell receptors specific for the NY-ESO-1 tumor antigen-HLA-A*02 complex
    Patent number: 11639374
    Abstract: The present invention relates to T cell receptors (TCRs) which bind the HLA-A*02 restricted peptide SLLMWITQC derived from the cancer antigen NY-ESO-1. Said TCRs may comprise mutations within the alpha and/or beta variable domains relative to a native NY-ESO-1 TCR. The TCRs of the invention are particularly suitable for use as novel immunotherapeutic reagents for the treatment of malignant disease.
    Type: Grant
    Filed: December 22, 2016
    Date of Patent: May 2, 2023
    Assignee: IMMUNOCORE LIMITED
    Inventors: Fiona Chester, Andrew Alexander Knox, Jonathan Patrick Lowther, Viren Vinubhai Patel, Emma Elizabeth Baston, Ruth Martinez Hague
  • T CELL RECEPTORS SPECIFIC FOR THE NY-ESO-1 TUMOR ANTIGEN-HLA-A*02 COMPLEX
    Publication number: 20190002523
    Abstract: The present invention relates to T cell receptors (TCRs) which bind the HLA-A*02 restricted peptide SLLMWITQC derived from the cancer antigen NY-ESO-1. Said TCRs may comprise mutations within the alpha and/or beta variable domains relative to a native NY-ESO-1 TCR. The TCRs of the invention are particularly suitable for use as novel immunotherapeutic reagents for the treatment of malignant disease.
    Type: Application
    Filed: December 22, 2016
    Publication date: January 3, 2019
    Inventors: Fiona CHESTER, Andrew Alexander KNOX, Jonathan Patrick LOWTHER, Viren Vinubhai PATEL, Emma Elizabeth BASTON, Ruth Martinez HAGUE