Abstract: Compositions and methods are disclosed for altering the binding affinity of calmodulin for ryanodine receptor 2 (RyR2). As disclosed herein, these therapeutic calmodulin (TCaM) proteins can be used to correct ryanopathies by prolonging the RyR2 refractory period. Therefore, also disclosed is a method for treating a ryanopathy-associated disease in a subject that involves administering to the subject a composition comprising a TCaM disclosed herein.

Abstract: Various embodiments include a structure configured to at least partially expose a barometric altimeter of an unmanned aerial vehicle (UAV) to air pressure at a location on the UAV where there is reduced pressure perturbations caused by downwash of propellers. The structure may include a proximal portion configured to encompass a barometric altimeter of a circuit board of the UAV. The proximal portion may form at least a partial barrier between the barometric altimeter and a first ambient air pressure that is disturbed by a downwash from propellers of the UAV during flight of the UAV. The structure may also include a distal portion extending away from the barometric altimeter, with the distal portion configured to channel to the barometric altimeter a second ambient air pressure that is disturbed less than the first ambient air pressure by the downwash from propellers of the UAV during flight of the UAV.

Abstract: Embodiments described herein relates to an Unmanned Aerial Vehicle (UAV) having vibration dampening and isolation capabilities, the UAV including a first frame portion, a second frame portion, and a third frame portion. Each of the first frame portion, the second frame portion, and the third frame portion is separated from one another. At least one first support member inelastically coupling the first frame portion and the third frame portion. At least one second support member elastically coupling the second frame portion and one or more of the first frame portion or the third frame portion to isolate the first frame portion and the third frame portion from vibration of the second frame portion.

Abstract: A method and system for preventing hung calls on a channel of a network interface device of a voice messaging system is described. A channel of the network interface device receives a new incoming call from the telephone network. If no other call is in progress on the same channel as the one on which the new call was received, the new incoming call is accepted. On the other hand, if another call is already in progress on this channel, the other call is terminated and the new incoming call is rejected. At this point, the network interface device is ready to accept any subsequent calls received on that channel.

Abstract: A “high availability” telephony/messaging system includes a first host comprising a first telephony application, a second host comprising a second telephony application, and a TSP for routing calls on a plurality of telephone circuits to the first and second hosts, for processing by one of the first and second applications. An Inter-System Call Transfer process permits a call routed to an application on one host to be transferred to an application on another host. Therefore, a call routed to a host that is unable to process the call can be redirected to another host that is able to process the call.