Patents by Inventor Jonathan Paul Simons

Jonathan Paul Simons has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Genetic construct of which protein coding DNA comprises introns and is designed for protein production in transgenic animals
    Patent number: 5861299
    Abstract: Proteinaceous products can be produced by transgenic animals having genetic constructs integrated into their genome. The construct comprises a 5'-flanking sequence from a mammalian milk protein gene (such as beta-lactoglobulin) and DNA coding for a heterologous protein other than the milk protein (for example a serin protease such as alpha.sub.1 -antitrypsin or a blood factor such as Factor VIII or IX). The protein-coding DNA comprises at least one, but not all, of the introns naturally occurring in a gene coding for the heterologous protein. The 5'-flanking sequence is sufficient to drive expression of the heterologous protein.
    Type: Grant
    Filed: November 17, 1994
    Date of Patent: January 19, 1999
    Assignee: PPL Therapeutics (Scotland) Limited
    Inventors: Alan Langskill Archibald, Anthony John Clark, Stephen Harris, Margaret McClenaghan, Jonathan Paul Simons, Christopher Bruce Alexander Whitelaw
  • Genetic construct of which protein coding DNA comprises introns and is designed for protein production in transgenic animals
    Patent number: 5650503
    Abstract: Proteinaceous products can be produced by transgenic animals having genetic constructs integrated into their genome. The construct comprises a 5'-flanking sequence from a mammalian milk protein gene (such as beta-lactoglobulin) and DNA coding for a heterologous protein other than the milk protein (for example a serin protease such as alpha.sub.1 -antitrypsin or a blood factor such as Factor VIII or IX). The protein-coding DNA comprises at least one, but not all, of the introns naturally occurring in a gene coding for the heterologous protein. The 5'-flanking sequence is sufficient to drive expression of the heterologous protein.
    Type: Grant
    Filed: December 20, 1994
    Date of Patent: July 22, 1997
    Assignee: PPL Therapeutics (Scotland) Limited
    Inventors: Alan Langskill Archibald, Anthony John Clark, Stephen Harris, Margaret McClenaghan, Jonathan Paul Simons, Christopher Bruce Alexander Whitelaw