Abstract: A flange clamp with an automatic fail safe preferably includes a first clamp half, a second clamp half, a lock lever, a hook member and a quick release pull pin. One end of the first clamp half is pivotally attached to one end of the second clamp half. A hook opening is formed on an opposing end of the first clamp half. The lock lever is pivotally retained on an opposing end of the second clamp half. The hook member includes a hook rod and a pivot block. The hook rod is threadably retained in the pivot block. The pivot block is pivotally retained by the lock lever. A mounting plate is attached to an outer surface of the second clamp half. The quick release pull pin is slidably retained in the mounting plate.