Patents by Inventor Jonathan Pevsner

Jonathan Pevsner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11452737
    Abstract: In one aspect, the present invention features a method of inhibiting proliferation and/or reducing survival of a cell comprising a GNAQ polynucleotide or polypeptide having a R183Q or Q209L mutation, comprising contacting the cell with puromycin or a puromycin analog, thereby inhibiting proliferation and/or reducing survival of the cell. In another aspect, a method of treating a vascular malformation or related condition in a subject, comprising administering to the subject an effective amount of puromycin or a puromycin analog is featured.
    Type: Grant
    Filed: July 28, 2016
    Date of Patent: September 27, 2022
    Assignees: The Johns Hopkins University, Duke University, Kennedy Krieger Institute, Inc.
    Inventors: Anne Comi, Jonathan Pevsner, Zhenhua Huang, Doug Marchuk
  • Publication number: 20200370118
    Abstract: The present invention relates to the fields of neurological and skin disorders. More specifically, the present invention provides methods and compositions for diagnosing and prognosing Sturge-Weber Syndrome (SWS), Klippel-Trenaunay-Weber Syndrome (KTWS), and Port Wine Stains (PWS).
    Type: Application
    Filed: January 7, 2020
    Publication date: November 26, 2020
    Inventors: Jonathan Pevsner, Anne Comi, Douglas Marchuk, Matthew Shirley
  • Publication number: 20200232033
    Abstract: The present invention provides methods for analyzing blocks of closely spaced SNPs, or haplotypes for use in identification of the origin of DNA in a sample. The methods comprise aligning common alleles of a gene of interest and identifying a region containing a plurality of SNPs which is flanked by non-polymorphic DNA which can be used for primer placement. Any sequencing method, including next generation sequencing methods can then be used to determine the haplotypes in the sample with a lower limit of detection of at least 0.01%. These inventive methods are useful, for example, for identification of hematopoietic stem cell transplantation patients destined to relapse, microchimerism associated with solid organ transplantation, detection of solid organ transplant rejection by detecting donor DNA in recipient plasma, forensic applications, and patient identification.
    Type: Application
    Filed: August 28, 2019
    Publication date: July 23, 2020
    Inventors: James R. Eshleman, Sarah J. Wheelan, Jonathan Pevsner
  • Patent number: 10544461
    Abstract: The present invention relates to the fields of neurological and skin disorders. More specifically, the present invention provides methods and compositions for diagnosing and prognosing Sturge-Weber Syndrome (SWS), Klippel-Trenaunay-Weber Syndrome (KTWS), and Port Wine Stains (PWS).
    Type: Grant
    Filed: April 16, 2014
    Date of Patent: January 28, 2020
    Assignees: The Johns Hopkins University, Kennedy Krieger Institute, Inc., Duke University
    Inventors: Jonathan Pevsner, Anne Comi, Douglas Marchuk, Matthew Shirley
  • Publication number: 20180235994
    Abstract: In one aspect, the present invention features a method of inhibiting proliferation and/or reducing survival of a cell comprising a GNAQ polynucleotide or polypeptide having a R183Q or Q209L mutation, comprising contacting the cell with puromycin or a puromycin analog, thereby inhibiting proliferation and/or reducing survival of the cell. In another aspect, a method of treating a vascular malformation or related condition in a subject, comprising administering to the subject an effective amount of puromycin or a puromycin analog is featured.
    Type: Application
    Filed: July 28, 2016
    Publication date: August 23, 2018
    Inventors: Anne Comi, Jonathan Pevsner, Zhenhua Huang, Doug Marchuk
  • Publication number: 20170218447
    Abstract: The present invention provides methods for analyzing blocks of closely spaced SNPs, or haplotypes for use in identification of the origin of DNA in a sample. The methods comprise aligning common alleles of a gene of interest and identifying a region containing a plurality of SNPs which is flanked by non-polymorphic DNA which can be used for primer placement. Any sequencing method, including next generation sequencing methods can then be used to determine the haplotypes in the sample with a lower limit of detection of at least 0.01%. These inventive methods are useful, for example, for identification of hematopoietic stem cell transplantation patients destined to relapse, microchimerism associated with solid organ transplantation, detection of solid organ transplant rejection by detecting donor DNA in recipient plasma, forensic applications, and patient identification.
    Type: Application
    Filed: August 5, 2015
    Publication date: August 3, 2017
    Inventors: James R. Eshleman, Sarah J. Wheelan, Jonathan Pevsner
  • Publication number: 20160237492
    Abstract: The present invention relates to the fields of neurological and skin disorders. More specifically, the present invention provides methods and compositions for diagnosing and prognosing Sturge-Weber Syndrome (SWS), Klippel-Trenaunay-Weber Syndrome (KTWS), and Port Wine Stains (PWS).
    Type: Application
    Filed: April 16, 2014
    Publication date: August 18, 2016
    Inventors: Jonathan Pevsner, Anne Comi, Douglas Marchuk, Matthew Shirley
  • Publication number: 20140336138
    Abstract: Compositions and methods for treatment of Sturge-Weber Syndrome, Klippel-Trenaunay-Weber Syndrome, Port-Wine Stains and related neurocutaneous disorders are provided. Cell lines having the somatic mutation GNAQ p.Arg183Gln amino acid substitution, which was found to be the cause of port-wine stains (prevalence 1 in 300) and Sturge-Weber syndrome are also provided. Compositions and methods for treatment of uveal melanoma are also provided herein. Methods of screening novel compounds and compositions useful in increasing RGS2 and/or RGS4 expression and function in vitro, and for treatment of Sturge-Weber Syndrome, Klippel-Trenaunay-Weber Syndrome, Port-Wine Stains and related neurocutaneous disorders are provided are also provided.
    Type: Application
    Filed: May 7, 2014
    Publication date: November 13, 2014
    Applicants: The Johns Hopkins University, Kennedy Krieger Institute, Inc.
    Inventors: Anne M. Comi, Jonathan Pevsner, Douglas Marchuk
  • Patent number: 5260270
    Abstract: DNA molecules are taught which code for an odorant-binding protein which is synethesized solely in the lateral nasal gland. This protein, because of the broad range of odorants which it binds, can be used in many techniques for trapping odorants in either a liquid or solid medium. This protein bears some structural homology with other carriers of small lipophilic molecules from many other species; the carriers are known to transport specific lipophilic molecules.
    Type: Grant
    Filed: July 15, 1991
    Date of Patent: November 9, 1993
    Assignee: The Johns Hopkins University
    Inventors: Solomon H. Snyder, Jonathan Pevsner, Randall Reed
  • Patent number: 5128246
    Abstract: DNA molecules are taught which code for an odorant-binding protein which is synthesized solely in the lateral nasal gland. This protein, because of the broad range of odorants which it binds, can be used in many techniques for trapping odorants in either a liquid or solid medium. This protein bears some structural homology with other carriers of small lipophilic molecules from many other species; the carriers are known to transport specific lipophilic molecules.
    Type: Grant
    Filed: March 13, 1990
    Date of Patent: July 7, 1992
    Assignee: The Johns Hopkins University
    Inventors: Solomon H. Snyder, Jonathan Pevsner, Randall Reed
  • Patent number: 5030722
    Abstract: DNA molecules are taught which code for an odorant-binding protein which is synthesized solely in the lateral nasal gland. This protein, because of the broad range of odorants which it binds, can be used in many techniques for trapping odorants in either a liquid or solid medium. This protein bears some structural homology with other carriers of small lipophilic molecules from many other species; the carriers are known to transport specific lipophilic molecules.
    Type: Grant
    Filed: March 30, 1988
    Date of Patent: July 9, 1991
    Assignee: The Johns Hopkins University
    Inventors: Solomon H. Snyder, Jonathan Pevsner, Randall Reed