Patents by Inventor Jonathan R. Heal

Jonathan R. Heal has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10815230
    Abstract: The present invention provides 2-Methyl-amino-3-[(4-fluorophenyl)carbonyl]indolizine-1-carboxamide of formula (I) or a pharmaceutically acceptable salt thereof; and its therapeutic uses in the treatment of neurodegenerative disorders, in particular tauopathies and most preferably in the treatment of Alzheimer's disease.
    Type: Grant
    Filed: May 13, 2016
    Date of Patent: October 27, 2020
    Assignee: ELECTROPHORETICS LIMITED
    Inventors: Ian H. Pike, Karsten Kuhn, Stefan Kienle, William D. O. Hamilton, Jonathan R. Heal, Joseph M. Sheridan
  • Publication number: 20190136270
    Abstract: Recombinant microorganisms, plants, and plant cells are disclosed that have been engineered to express a mutant AROM polypeptide and/or mutant catechol-O-methyltransferase polypeptide alone or in combination with one or more vanillin biosynthetic enzymes or UDP-glycosyltransferases (UGTs). Such microorganisms, plants, or plant cells can produce vanillin or vanillin beta-D-glucoside.
    Type: Application
    Filed: January 9, 2019
    Publication date: May 9, 2019
    Inventors: Joergen HANSEN, Esben Halkjaer HANSEN, Honey POLUR, Joseph M. SHERIDAN, Jonathan R. HEAL, William D.O. HAMILTON
  • Patent number: 10208293
    Abstract: Recombinant microorganisms, plants, and plant cells are disclosed that have been engineered to express a mutant AROM polypeptide and/or mutant catechol-O-methyltransferase polypeptide alone or in combination with one or more vanillin biosynthetic enzymes or UDP-glycosyltransferases (UGTs). Such microorganisms, plants, or plant cells can produce vanillin or vanillin beta-D-glucoside.
    Type: Grant
    Filed: August 7, 2012
    Date of Patent: February 19, 2019
    Assignees: International Flavors & Fragrances Inc., Evolva SA
    Inventors: Joergen Hansen, Esben Halkjaer Hansen, Honey Polur, Joseph M. Sheridan, Jonathan R. Heal, William D. O. Hamilton
  • Patent number: 10119154
    Abstract: The present disclosure provides methods for identifying anthocyanins with improved stability, color, or hue using a screening method, and producing anthocyanins with improved stability, color, or hue in, for example, host cells comprising one or more heterologous glycosyltransferase nucleic acid molecules and one or more heterologous acyltransferase nucleic acid molecules.
    Type: Grant
    Filed: December 23, 2013
    Date of Patent: November 6, 2018
    Assignee: Evolva SA
    Inventors: Jorgen Hansen, Patricia Hoyle, Michael Naesby, Joseph M. Sheridan, Jonathan R. Heal
  • Publication number: 20180186786
    Abstract: The present invention provides 2-Methyl-amino-3-[(4-fluorophenyl)carbonyl]indolizine-1-carboxamide of formula (I) or a pharmaceutically acceptable salt thereof; and its therapeutic uses in the treatment of neurodegenerative disorders, in particular tauopathies and most preferably in the treatment of Alzheimer's disease.
    Type: Application
    Filed: May 13, 2016
    Publication date: July 5, 2018
    Applicant: ELECTROPHORETICS LIMITED
    Inventors: Ian H. Pike, Karsten Kuhn, Stefan Kienle, William D.O. Hamilton, Jonathan R. Heal, Joseph M. Sheridan
  • Patent number: 9789111
    Abstract: The invention relates to pharmaceutical compositions having casein kinase 1 delta (CK1?) inhibitors and to the use of the inhibitors in the treatment of neurodegenerative disorders such as Alzheimer's disease.
    Type: Grant
    Filed: April 2, 2015
    Date of Patent: October 17, 2017
    Assignee: ELECTROPHORETICS LIMITED
    Inventors: Joseph M. Sheridan, Jonathan R. Heal, William D. O. Hamilton, Ian H. Pike
  • Patent number: 9763947
    Abstract: The invention relates to pharmaceutical compositions having casein kinase 1 delta (CK1?) inhibitors and to the use of the inhibitors in the treatment of neurodegenerative disorders such as Alzheimer's disease.
    Type: Grant
    Filed: September 1, 2015
    Date of Patent: September 19, 2017
    Assignee: ELECTROPHORETICS LIMITED
    Inventors: Joseph M. Sheridan, Jonathan R. Heal, William D. O. Hamilton, Ian H. Pike
  • Publication number: 20160354375
    Abstract: The invention relates to pharmaceutical compositions comprising casein kinase 1 delta (CK1?) and to the use of said inhibitors in the treatment of neurodegenerative disorders such as Alzheimer's disease.
    Type: Application
    Filed: June 2, 2016
    Publication date: December 8, 2016
    Applicant: Electrophoretics Limited
    Inventors: Joseph M. Sheridan, Jonathan R. Heal, William D.O. Hamilton, Ian Pike
  • Publication number: 20160058745
    Abstract: The invention relates to pharmaceutical compositions having casein kinase 1 delta (CK1?) inhibitors and to the use of the inhibitors in the treatment of neurodegenerative disorders such as Alzheimer's disease.
    Type: Application
    Filed: September 1, 2015
    Publication date: March 3, 2016
    Applicant: Electrophoretics Limited
    Inventors: Joseph M. Sheridan, Jonathan R. Heal, William D.O. Hamilton, Ian H. Pike
  • Publication number: 20150344920
    Abstract: The present disclosure provides methods for identifying anthocyanins with improved stability, color, or hue using a screening method, and producing anthocyanins with improved stability, color, or hue in, for example, host cells comprising one or more heterologous glycosyltransferase nucleic acid molecules and one or more heterologous acyltransferase nucleic acid molecules.
    Type: Application
    Filed: December 23, 2013
    Publication date: December 3, 2015
    Applicant: Evolva SA
    Inventors: Jorgen Hansen, Patricia Hoyle, Michael Naesby, Joseph M. Sheridan, Jonathan R. Heal
  • Publication number: 20150209368
    Abstract: The invention relates to pharmaceutical compositions having casein kinase 1 delta (CK1?) inhibitors and to the use of the inhibitors in the treatment of neurodegenerative disorders such as Alzheimer's disease.
    Type: Application
    Filed: April 2, 2015
    Publication date: July 30, 2015
    Applicant: Electrophoretics Limited
    Inventors: Joseph M. Sheridan, Jonathan R. Heal, William D.O. Hamilton, Ian H. Pike
  • Publication number: 20150057443
    Abstract: Cycloalkyl amine compounds of Formula (I), wherein ring A is C3-C6 cycloalkyl, optionally substituted with one or more C1-C3 alkyl, and R5 is ORS2, in which RS2 is H or C1-C6 alkyl, or R5 and R6, together with the carbon atom to which they are attached, form C?O, for use in treating CNS disorders, including movement disorders, depressive disorders, sleep disorders, cognitive dysfunctions, obesity, sexual dysfunction and substance abuse.
    Type: Application
    Filed: August 21, 2014
    Publication date: February 26, 2015
    Inventors: Philip Huxley, Jonathan R. Heal, Richard S. Todd
  • Publication number: 20140245496
    Abstract: Recombinant microorganisms, plants, and plant cells are disclosed that have been engineered to express a mutant AROM polypeptide and/or mutant catechol-O-methyltransferase polypeptide alone or in combination with one or more vanillin biosynthetic enzymes or UDP-glycosyltransferases (UGTs). Such microorganisms, plants, or plant cells can produce vanillin or vanillin beta-D-glucoside.
    Type: Application
    Filed: August 7, 2012
    Publication date: August 28, 2014
    Applicants: EVOLVA SA, INTERNATIONAL FLAVORS & FRAGRANCES INC.
    Inventors: Joergen Hansen, Esben Halkjaer Hansen, Honey Polur, Joseph M. Sheridan, Jonathan R. Heal, William D.O. Hamilton
  • Publication number: 20140031547
    Abstract: The invention relates to pharmaceutical compositions comprising casein kinase 1 delta (CK1?) and to the use of said inhibitors in the treatment of neurodegenerative disorders such as Alzheimer's disease.
    Type: Application
    Filed: December 14, 2011
    Publication date: January 30, 2014
    Inventors: Joseph M. Sheridan, Jonathan R. Heal, William D.O. Hamilton, Ian Pike
  • Publication number: 20140018540
    Abstract: The invention relates to pharmaceutical compositions comprising casein kinase 1 delta (CK1?) and to the use of said inhibitors in the treatment of neurodegenerative disorders such as Alzheimer's disease.
    Type: Application
    Filed: December 14, 2011
    Publication date: January 16, 2014
    Inventors: Joseph M. Sheridan, Jonathan R. Heal, William D.O. Hamilton, Ian Pike
  • Publication number: 20090131502
    Abstract: The present invention relates to compounds of formula (I), and pharmaceutically acceptable salts thereof. The invention further relates to pharmaceutical compositions comprising compounds of formula (I), and the use of such compounds in the treatment of a disease selected from osteoporosis, Paget's disease, Chagas's disease, malaria, gingival diseases, hypercalaemia, metabolic bone disease and diseases involving matrix or cartilate degradation.
    Type: Application
    Filed: February 25, 2008
    Publication date: May 21, 2009
    Inventors: Martin Quibell, John Paul Watts, Yikang Wang, Lee Patient, Jonathan R. Heal
  • Patent number: 6721663
    Abstract: This method enables computational analysis and manipulation of DNA and protein sequence data such as is found in large public databases. The method allows systematic searches of such data to identify portions of sequences which code for key intermolecular surfaces or regions of specific protein targets. In a first example, two amino acid sequences are input (steps 1, 2) to an iterative procedure (steps 4-6). A frame size is selected in terms of a number of sequence elements. The procedure then compares pairs of frames, one from each sequence, to identify intramolecular and intermolecular regions on the basis of relationships between amino acids according to a predetermined coding scheme. The probability of existence of each region within the coding scheme is then evaluated and those regions for which the probability is greater than a predetermined threshold are discarded. The procedure outputs the remaining regions.
    Type: Grant
    Filed: May 16, 2000
    Date of Patent: April 13, 2004
    Assignee: Proteom Limited
    Inventors: Gareth W. Roberts, Jonathan R. Heal
  • Publication number: 20030199011
    Abstract: In the current invention the application of our novel informatics approach to the databases containing nucleotide and peptide sequences from pathogens generates the sequence of many peptides which form the basis of an innovative and novel approach to developing anti-infective drugs.
    Type: Application
    Filed: May 18, 2000
    Publication date: October 23, 2003
    Inventors: Garth W. Roberts, Jonathan R. Heal
  • Publication number: 20030148368
    Abstract: In the current invention the application of our novel informatics approach to the databases containing nucleotide and peptide sequences from plant genomes generates the sequence of many peptides which form the basis of an innovative and novel approach to developing new therapeutic agents.
    Type: Application
    Filed: May 17, 2000
    Publication date: August 7, 2003
    Inventors: Gareth W. Roberts, Jonathan R. Heal
  • Publication number: 20030078374
    Abstract: In the current invention the application of our novel informatics approach to the databases containing nucleotide and peptide sequences from the human genome generates the sequence of many peptides which form the basis of an innovative and novel approach to developing new therapeutic agents.
    Type: Application
    Filed: May 17, 2000
    Publication date: April 24, 2003
    Inventors: Gareth W. Roberts, Jonathan R. Heal