Abstract: Systems and method for estimating treatment effects for a target trial in accordance with embodiments of the invention are illustrated. One embodiment includes a method. The method defines a skedastic function model, wherein defining the skedastic function model depends, at least in part, on target trial data. The method designs trial parameters for the target trial based in part on the skedastic function model. The method applies the trial parameters to a loss function to derive at least one minimizing coefficient, wherein a minimizing coefficient corresponds to a regression coefficient for an expected outcome to the target trial based on the trial parameters. The method computes standard errors for the at least one minimizing coefficient. The method quantifies, using the standard errors, values for uncertainty associated with the target trial. The method updates the trial parameters according to the uncertainty.

Abstract: Systems and methods for training and utilizing constrained generative models in accordance with embodiments of the invention are illustrated. One embodiment includes a method for training a constrained generative model. The method includes steps for receiving a set of data samples from a first distribution, identifying a set of constraints from a second distribution, and training a generative model based on the set of data samples and the set of constraints.

Abstract: Systems and methods for training and utilizing constrained generative models in accordance with embodiments of the invention are illustrated. One embodiment includes a method for training a constrained generative model. The method includes steps for receiving a set of data samples from a first distribution, identifying a set of constraints from a second distribution, and training a generative model based on the set of data samples and the set of constraints.