Abstract: The disclosure features methods of treating a subject with acne, enlarged pores, hidradenitis, seborrhea, sebaceous hyperplasia, seborrheic dermatitis, sebaceous adenoma, sebaceous carcinoma, sebaceous cyst, wrinkles, or oily skin suppurativa by administration of a dexmecamylamine substantially free of exo-R-mecamylamine, or a pharmaceutically acceptable salt thereof to the subject.

Abstract: The present invention features compositions including sepiapterin, or a pharmaceutically acceptable salt thereof, and methods for the treatment of BH4-related disorders. In some embodiments, these compositions and methods result in an increase in plasma, CSF, and/or brain exposure of sepiapterin.

Abstract: The present invention features compositions including sepiapterin, or a pharmaceutically acceptable salt thereof, and methods for the treatment of BH4-related disorders. In some embodiments, these compositions and methods result in an increase in plasma, CSF, and/or brain exposure of sepiapterin.

Abstract: The present invention relates to new pharmaceutical salts and/or co-crystals of sepiapterin which exhibit improved properties. In particular, the invention relates to salts of sepiapterin with improved stability. The invention also relates to pharmaceutical compositions including a pharmaceutically effective amount of one or more salts and/or co-crystals of sepiapterin, as well as methods of treating tetrahydrobiopterin-related disorders including administration of a sepiapterin salt and/or co-crystal of the invention to a subject in need thereof.

Abstract: The present invention features compositions including sepiapterin, or a pharmaceutically acceptable salt thereof, and methods for the treatment of BH4-related disorders. In some embodiments, these compositions and methods result in an increase in plasma, CSF, and/or brain exposure of sepiapterin.

Abstract: The present invention features compositions including sepiapterin, or a pharmaceutically acceptable salt thereof, and methods for the treatment of BH4-related disorders. In some embodiments, these compositions and methods result in an increase in plasma exposure of BH4.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for providing content on a social messaging platform. One of the methods includes providing a plurality of messages of a social messaging platform to a user device, the plurality of messages being part of a conversation; receiving a request associated with one of the plurality of messages, the request including an indication to repost a collection of messages; providing a selection user interface, the selection user interface including the plurality of messages and a respective selection indicator for each message; receiving a user selection of two or more messages; responsive to the user selection, generating a message composition interface, the message composition interface including a representation of the selected messages; and in response to user input, posting the representation of the selected messages as part of a new message of the user on the platform.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for providing content on a social messaging platform. One of the methods includes providing a plurality of messages of a social messaging platform to a user device, the plurality of messages being part of a conversation; receiving a request associated with one of the plurality of messages, the request including an indication to repost a collection of messages; providing a selection user interface, the selection user interface including the plurality of messages and a respective selection indicator for each message; receiving a user selection of two or more messages; responsive to the user selection, generating a message composition interface, the message composition interface including a representation of the selected messages; and in response to user input, posting the representation of the selected messages as part of a new message of the user on the platform.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for providing content on a social messaging platform. One of the methods includes providing a plurality of messages of a social messaging platform to a user device, the plurality of messages being part of a conversation; receiving a request associated with one of the plurality of messages, the request including an indication to repost a collection of messages; providing a selection user interface, the selection user interface including the plurality of messages and a respective selection indicator for each message; receiving a user selection of two or more messages; responsive to the user selection, generating a message composition interface, the message composition interface including a representation of the selected messages; and in response to user input, posting the representation of the selected messages as part of a new message of the user on the platform.

Abstract: An image transfer object is disclosed that provides the necessary mechanism to conduct a dynamic transfer operation. The image transfer object includes a static reference to dynamic data. The image data is “dynamic”, in that the user may request additional views of the image. An image recipient computer receives the static reference to identify a source image on a server, and generates a first request, based on the static reference, for a view of the source image to the server. In response, the server transmits data to the image recipient computer. The image recipient computer displays the first view of the source image for viewing by the user. The user may then select a different portion of the source image, and/or a different resolution to designate a second view of the source image. The image recipient computer generates a second request to the image server for the second view, and the image server transmits additional data to generate the second view of the source image.