Patents by Inventor Jonathan Richard Heal

Jonathan Richard Heal has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Mutant proteins and methods for producing them
    Patent number: 8748182
    Abstract: Aspects of the invention relate to methods of producing a mutant GPCR with increased stability relative to its parent GPCR.
    Type: Grant
    Filed: December 8, 2008
    Date of Patent: June 10, 2014
    Assignee: Heptares Therapeutics Limited
    Inventors: Jonathan Richard Heal, Richard Henderson, Christopher Gordon Tate, Malcolm Peter Weir
  • 1, 2, 4-triazole derivatives as serotonergic modulators
    Patent number: 8222254
    Abstract: The invention relates to novel 5-hydroxytryptamine (5-HT) receptor modulator compounds of formula (I); wherein A, B, R1-R5, T, W, X, Y, Z and m are defined herein, to pharmaceutical compositions comprising these compounds and to their use in the treatment of conditions associated with 5-HT action.
    Type: Grant
    Filed: August 6, 2008
    Date of Patent: July 17, 2012
    Assignee: Prosarix Limited
    Inventors: Jonathan Richard Heal, Joseph Michael Sheridan, William Dennys Ormrod Hamilton, Simon James Grimshaw, Sorin Vasile Filip
  • MUTANT PROTEINS AND METHODS FOR PRODUCING THEM
    Publication number: 20110028700
    Abstract: A method of producing a mutant G-protein coupled receptor (GPCR) with increased stability relative to its parent GPCR, the method comprising: a) providing one or more mutants of a first parent GPCR with increased stability relative to the first parent GPCR b) identifying in a structural membrane protein model the structural motif or motifs in which the one or more mutants have at least one different amino acid residue compared to the first parent GPCR, and c) making one or more mutations in the amino acid sequence that defines a corresponding structural motif or motifs in a second parent GPCR, to provide one or more mutants of a second parent GPCR with increased stability relative to the second parent GPCR. Mutants of ?-adrenergic receptor, adenosine receptor and neurotensin receptor are also disclosed.
    Type: Application
    Filed: December 8, 2008
    Publication date: February 3, 2011
    Inventor: Jonathan Richard Heal
  • 1, 2, 4 -TRIAZOLE DERIVATIVES AS SEROTONERGIC MODULATORS
    Publication number: 20100261732
    Abstract: The invention relates to novel 5-hydroxytryptamine (5-HT) receptor modulator compounds of formula (I); wherein A, B, R1-R5, T, W, X, Y, Z and m are defined herein, to pharmaceutical compositions comprising these compounds and to their use in the treatment of conditions associated with 5-HT action.
    Type: Application
    Filed: August 6, 2008
    Publication date: October 14, 2010
    Inventors: Jonathan Richard Heal, Joseph Michael Sheridan, William Dennys Ormrod Hamilton, Simon James Grimshaw, Sorin Vasile Filip
  • Apparatus and method for predicting rules of protein sequence interactions
    Publication number: 20030059844
    Abstract: This invention relates to the prediction of protein sequence interactions. A method and apparatus are described for discovering rules of protein sequence interactions using a machine learning approach. The system uses a database of known protein sequence interactions, an algorithm to asses predictive quality of rules on one or more subsets of a protein sequence interaction database and a technique for generating new rule sets for testing. The system aims to optimise a rule set (descriptors of protein sequence interactions) against one or more predetermined criteria. One or more pairs of protein sequences which are likely to interact are generated according to the rule sets thus generated.
    Type: Application
    Filed: August 13, 2002
    Publication date: March 27, 2003
    Applicant: Proteom Limited
    Inventors: Jonathan Richard Heal, Jonathan Swinton, Robert Geoffrey Cooper