Abstract: The invention is directed to a method for activating CAR cells having at least one chimeric antigen binding receptor in a sample by incubating the sample with at least one substrate provided on its surface with at least one anti-CAR idiotype antibody and/or at least one antigen selected from the group consisting of CD19, CD20, CD22, BCMA, CD33, MSLN, CD123, HER2, GD2, EGFR, PSMA, MUC1, CD318, TSPAN8, CD66c, CEA, CLA, CD276, FolR1, CLEC12A, CLL-1 and CD371, and with at least one costimulatory molecule selected from the group consisting of CD28, CD2, CD6, CD26, CD53 and LFA-1 characterized in that the sample is incubated with the at least substrate in suspension thereby activating the CAR T cells to express markers selected from the group consisting of mRNA, effector molecules or cell surface activation markers.

Abstract: Disclosed is a system and method for providing a steel structural support to bear the weight of one and/or multiple vertical pipe runs traveling down an extended length vertical shaft. The low profile support of the present invention requires minimal space for attachment inside the diameter of the shaft allowing for maximum space to accommodate hoisting and bulky lifts within the shafts. The system provides the means for supporting vertical pipe runs without the need for additional load bearing strapping or supports within the length of the shaft, further allowing for maximum clearance within the shaft and at the shaft collar.

Abstract: The invention includes methods of collecting crude oil and apparatus which collect crude oil. In one implementation, a crude oil collection header apparatus comprises a collection reservoir. A plurality of fluid conduits is connected to feed crude oil to the collection reservoir. The fluid conduits respectively comprise a collection reservoir feed valve, a bypass valve, and a crude oil feed inlet received between the collection reservoir feed and bypass valves. A flow meter conduit is connected with multiple of the plurality of fluid conduits downstream of the respective bypass valves. A flow meter is operably connected with the flow meter conduit. A crude oil outlet is associated with the collection reservoir. Other aspects and implementations are disclosed.

Abstract: The invention includes methods of collecting crude oil and apparatus which collect crude oil. In one implementation, a crude oil collection header apparatus includes a collection reservoir and a plurality of fluid conduits connected to feed crude oil to the collection reservoir. The fluid conduits respectively include a collection reservoir feed valve, a bypass valve, and a crude oil feed inlet received between the collection reservoir feed and bypass valves. A bypass conduit to which the fluid conduits connect is received downstream of the respective bypass valves. The bypass conduit includes a gas separator device. A flow meter conduit is connected with the bypass conduit downstream of the gas separator device. A flow meter is operably connected with the flow meter conduit. A crude oil outlet is associated with the collection reservoir. Other aspects and implementations are disclosed.

Abstract: The invention includes methods of collecting crude oil and apparatus which collect crude oil. In one implementation, a crude oil collection header apparatus includes a collection reservoir and a plurality of fluid conduits connected to feed crude oil to the collection reservoir. The fluid conduits respectively include a collection reservoir feed valve, a bypass valve, and a crude oil feed inlet received between the collection reservoir feed and bypass valves. A bypass conduit to which the fluid conduits connect is received downstream of the respective bypass valves. The bypass conduit includes a gas separator device. A flow meter conduit is connected with the bypass conduit downstream of the gas separator device. A flow meter is operably connected with the flow meter conduit. A crude oil outlet is associated with the collection reservoir. Other aspects and implementations are disclosed.

Abstract: The invention includes methods of collecting crude oil and apparatus which collect crude oil. In one implementation, a crude oil collection header apparatus comprises a collection reservoir. A plurality of fluid conduits is connected to feed crude oil to the collection reservoir. The fluid conduits respectively comprise a collection reservoir feed valve, a bypass valve, and a crude oil feed inlet received between the collection reservoir feed and bypass valves. A flow meter conduit is connected with multiple of the plurality of fluid conduits downstream of the respective bypass valves. A flow meter is operably connected with the flow meter conduit. A crude oil outlet is associated with the collection reservoir. Other aspects and implementations are disclosed.