Patents by Inventor Jonathan S. Dordick
Jonathan S. Dordick has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20120021486Abstract: The invention relates to decontaminating composites, and methods, compositions, and kits comprising the same. In some aspects, the invention relates to a decontaminating composite, comprising a perhydrolase associated with a carbon nanotube, that is useful for producing peracids.Type: ApplicationFiled: January 15, 2010Publication date: January 26, 2012Inventors: Cerasela Zoica Dinu, Jonathan S. Dordick, Ravindra S. Kane, Karl Sanford, Gregory M. Whited, Guangyu Zhu
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Publication number: 20110305903Abstract: Embodiments of the invention provide a cellulose-sheathed carbon nanotube fiber. One aspect of the invention provides a sheathed nanotube fiber comprising: a carbon nanotube fiber; and a cellulose sheath extending co-axially along at least a first portion of a length of the carbon nanotube fiber. Another aspect of the invention provides a method of forming a sheathed carbon nanotube fiber, the method comprising: co-electrospinning a carbon nanotube fiber gel core within a cellulose solution sheath.Type: ApplicationFiled: June 10, 2011Publication date: December 15, 2011Applicant: RENNSSELAER POLYTECHNIC INSTITUTEInventors: Minoru Miyauchi, Jianjun Miao, Trevor J. Simmons, Jong-Won Lee, Thomas V. Doherty, Jonathan S. Dordick, Robert J. Linhardt
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Publication number: 20110190402Abstract: The invention is directed a synthetic wood composite comprising biomimetic macromolecules and methods for the preparation thereof.Type: ApplicationFiled: August 3, 2010Publication date: August 4, 2011Inventors: Robert J. Linhardt, Jonathan S. Dordick, Trevor J. Simmons, Minoru Miyauchi, Sang-Hyun Lee
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Publication number: 20110190162Abstract: The invention is directed to a three-dimensional cell culture array comprising spatially-separated matrices attached to a solid support, wherein a plurality of said matrices encapsulate cells transfected with nucleic acids, method for the preparation of the array and methods reducing the expression of a target gene.Type: ApplicationFiled: November 12, 2010Publication date: August 4, 2011Inventors: Moo-Yeal Lee, Seok Joon Kwon, Jonathan S. Dordick, Douglas S. Clark, Jessica R. McKinley
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Publication number: 20110070440Abstract: Using digital microfluidics, recombinant enzyme technology, and magnetic nanoparticles, a functional prototype of an artificial Golgi organelle is described. Analogous to the natural Golgi, which is responsible for the enzymatic modification of glycosaminoglycans immobilized on proteins, this artificial Golgi enzymatically modifies glycosaminoglycans, such as heparan sulfate (HS) chains, immobilized onto magnetic nanoparticles. Sulfo groups were transferred from adenosine 3?-phosphate 5?-phosphosulfate to the 3-hydroxyl group of the D-glucosamine residue in an immobilized HS chain using D-glucosaminyl 3-O-sulfotransferase. After modification, the nanoparticles with immobilized HS exhibited increased affinity for fluorescently labeled antithrombin III as detected by confocal microscopy. Since the biosynthesis of HS involves an array of specialized glycosyl transferases, epimerase, and sulfotransferases, this approach should mimic the synthesis of HS in vivo.Type: ApplicationFiled: July 7, 2010Publication date: March 24, 2011Inventors: Robert J. Linhardt, Jonathan S. Dordick
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Publication number: 20110015088Abstract: A system and method for conducting high-throughput interactions between test compositions and analytes, comprising one or more test compositions, and a plurality of independent micromatrices, wherein each said micromatrix encapsulates at least one said test composition; and said micromatrices are made of a material that is permeable to an analyte.Type: ApplicationFiled: June 21, 2010Publication date: January 20, 2011Applicants: Rensselaer Polytechnic Institute, The Regents of the University of CaliforniaInventors: Jonathan S. Dordick, Douglas S. Clark
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Patent number: 7846747Abstract: A system and method for conducting high-throughput interactions between test compositions and analytes, comprising one or more test compositions, and a plurality of independent micromatrices, wherein each said micromatrix encapsulates at least one said test composition; and said micromatrices are made of a material that is permeable to an analyte.Type: GrantFiled: November 13, 2006Date of Patent: December 7, 2010Assignees: Rensselaer Polytechnic Institute, The Regents of the University of CaliforniaInventors: Jonathan S. Dordick, Douglas S. Clark
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Publication number: 20090221441Abstract: The present invention is directed to a screening platform employing a miniaturized three-dimensional cell chip for high-throughput toxicology screening of test and lead compounds, prodrugs, drugs and P-450 generated drug metabolites. To this end, the three-dimensional cell chip, employs human cells encapsulated in a matrix (e.g., collagen or alginate gels) in volumes as small as 10 nL arrayed on a functionalized substrates (e.g., glass microscope slides) for spatially addressable screening against multiple test compounds. With the present platform, over 3,000 cell-matrix islands may be spotted providing for simultaneous screening against multiple compounds at multiple doses and in high replicate.Type: ApplicationFiled: October 31, 2006Publication date: September 3, 2009Applicants: Regents of the University of CaliforniaInventors: Moo-Yeal Lee, Anand K. Ramasubramanian, Douglas S. Clark, Jonathan S. Dordick
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Publication number: 20090143487Abstract: This invention is directed to the application of a previously unknown property of nanomaterials—its ability to enhance protein activity and stability at high temperatures, in organic solvents, and in polymer composites. Nanomaterials such as single-walled carbon nanotubes (SWNTs) can significantly enhance enzyme function and stability in strongly denaturing environments. Experimental results and theoretical analysis reveal that the enhancement in stability is a result of the curvature of these nanoscale materials, which suppresses unfavorable protein-protein interactions. The enhanced stability is also exploited in the preparation of highly stable and active nanocomposite films that resist nonspecific protein absorption, i.e., inhibit fouling of the films. The protein-nanoparticles conjugates represent a new generation of highly selective, active, and stable catalytic materials.Type: ApplicationFiled: September 7, 2005Publication date: June 4, 2009Inventors: Jonathan S. Dordick, Ravindra S. Kane, Prashanth Asuri, Sandeep S. Karajanagi
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Patent number: 7439343Abstract: Aminoglycoside-polyamines are disclosed along with methods of use thereof in displacement chromatography and as DNA-binding ligands. The aminoglycoside-polyamines are derivatives of carbohydrates, such as sugars, amino sugars, deoxysugars, glycosides, nucleosides and their substituted counterparts. The subject polyamines possess a group in place of at least one hydrogen atom of at least one hydroxyl group of the carbohydrate compound. In these compounds R1 is an alkyl group or an azaalkyl group, and R2 is a primary or secondary amino group.Type: GrantFiled: September 1, 2005Date of Patent: October 21, 2008Assignee: Rensselaer Polytechnic InstituteInventors: Kaushal Rege, Shanghui Hu, Jonathan S. Dordick, Steven M. Cramer
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Patent number: 7427497Abstract: Disclosed herein is a microfluidics device that can be used to prepare natural products and their analogs. The device comprises the enzymes of a biosynthetic pathway immobilized thereon and a means for sequentially directing a starting material and each ensuing reaction product to the enzymes of the biosynthetic pathway in the order corresponding to the steps of the biosynthetic pathway. The device can thus be used to prepare the natural product using the natural starting material of the biosynthetic pathway or analogs of the natural product using an unnatural starting material. Alternatively, artificial pathways can be created by immobilizing an appropriate selection of enzymes on the device in an order whereby each subsequent enzyme can catalyze a reaction with the product of the prior enzyme. Novel chemical entities can be prepared from these artificial pathways.Type: GrantFiled: November 1, 2002Date of Patent: September 23, 2008Assignees: Rensselaer Polytechnic Institute, Darpa, The Regents of the University of CaliforniaInventors: Jonathan S. Dordick, Aravind Srinivasan, Jungbae Kim, David H. Sherman, Douglas S. Clark
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Patent number: 7267958Abstract: A system and method for conducting high-throughput interactions between test compositions and analytes, comprising one or more test compositions, and a plurality of independent micromatrices, wherein each said micromatrix encapsulates at least one said test composition; and said micromatrices are made of a material that is permeable to an analyte.Type: GrantFiled: November 1, 2002Date of Patent: September 11, 2007Assignees: Rensselaer Polytechnic Institute, The Regents of the University of CaliforniaInventors: Jonathan S. Dordick, Douglas S. Clark
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Patent number: 7202030Abstract: This invention relates to the enzymatic synthesis of oligophenols on solid support by sequential enzymatic addition of reaction solutions containing phenols. The oligomers are then selectively built up on the solid surface. When used in a specific format, the oligomers can be generated in a spatially addressable array, which can then be screened for some type of biological interaction. The synthetic compounds of the present invention are synthesized in a combinatorial manner on solid support using peroxidase or other related enzymatic catalysis, and the products are generated in spatially addressable microarrays. Oligophenols of the present invention have shown significance as potential inhibitors of NADPH oxidase assembly, an enzyme that has been implicated in a wide range of diseases stemming from vascular hyperpermeability.Type: GrantFiled: November 1, 2002Date of Patent: April 10, 2007Assignees: Rensselaer Polytechnic Institute, The United States of America as represented by the Secretary, Department of Veterans AffairsInventors: Jonathan S. Dordick, Lakshmi Santhanam, Michael G. Hogg, James A. Holland
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Patent number: 7172682Abstract: Disclosed herein is a method and apparatus of immobilizing a biocatalyst on a microfluidic biochip for conducting reactions in the presence of electroosmotic flow. The biochip includes a polymer on its microfluidic flow surfaces, wherein the polymer includes a first substituent selected from ionic groups of the same polarity or precursors thereof, a second substituent that is a hydrophobic group, and a third substituent comprising an immobilized biocatalyst-or precursor thereof. The biochip can be used to conduct multiple sequential biocatalyzed reactions in the presence of electroosmotic flow.Type: GrantFiled: January 24, 2003Date of Patent: February 6, 2007Assignee: Rensselaer Polytechnic InstituteInventors: Jonathan S. Dordick, Moo-Yeal Lee, Aravind Srinivasan, Bosung Ku
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Publication number: 20040186459Abstract: A fluid delivery technique includes inserting a first end of a nanotube into the cell, connecting a second end of the nanotube to a fluid supply, and transferring fluid from the fluid supply into the cell via the nanotube. A technique for determining or sensing a property of a cell includes inserting two nanotubes into the cell, measuring at least one of a voltage and a resistance between the two nanotubes, and relating the at least one of the voltage and the resistance to a property of the cell. Other techniques and apparatus for fluid delivery to cell and sensing properties of a cell are also disclosed.Type: ApplicationFiled: March 20, 2003Publication date: September 23, 2004Inventors: Michael Shur, Jonathan S. Dordick, Pulickel M. Ajayan
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Publication number: 20040137582Abstract: The invention is based upon the discovery that insoluble, polysaccharides, such as inulin and dextran, can be enzymatically modified in an organic solvent. Thus, the invention relates to methods for making a high molecular weight polyhydroxy polymer, such as a polysaccharide, inulin or dextran derivative, comprising reacting an acyl donor and the polymer, such as inulin or dextran, to form an acyl ester of the polymer, such as inulin dextran, in a reaction medium comprising an organic solvent in the presence of a hydrolytic enzyme; methods for making a polymer, such as a polysaccharide, an inulin or dextran polymer, comprising reacting a polymerizable acyl donor and polyhydroxyl polymer in a reaction medium comprising an organic solvent in the presence of a hydrolytic enzyme thereby making an polymeric monomer, such as an inulin monomer, and polymerizing, preferably dimerizing, the monomer, thereby making a novel polymer, such as an inulin polymer.Type: ApplicationFiled: September 15, 2003Publication date: July 15, 2004Inventors: Jonathan S. Dordick, Lino Ferreira
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Publication number: 20040062687Abstract: Disclosed herein is a microfluidics device that can be used to prepare natural products and their analogs. The device comprises the enzymes of a biosynthetic pathway immobilized thereon and a means for sequentially directing a starting material and each ensuing reaction product to the enzymes of the biosynthetic pathway in the order corresponding to the steps of the biosynthetic pathway. The device can thus be used to prepare the natural product using the natural starting material of the biosynthetic pathway or analogs of the natural product using an unnatural starting material. Alternatively, artificial pathways can be created by immobilizing an appropriate selection of enzymes on the device in an order whereby each subsequent enzyme can catalyze a reaction with the product of the prior enzyme. Novel chemical entities can be prepared from these artificial pathways.Type: ApplicationFiled: November 1, 2002Publication date: April 1, 2004Applicant: Rensselaer Polytechnic InstituteInventors: Jonathan S. Dordick, Aravind Srinivasan, Jungbae Kim, David H. Sherman, Douglas S. Clark
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Patent number: 6713416Abstract: A method of making a molecularly imprinted porous structure makes use of a surfactant analog of the molecule to be imprinted that has the imprint molecule portion serving as the surfactant headgroup. The surfactant analog is allowed to self-assemble in a mixture to create at least one supramolecular structure having exposed imprint groups. The imprinted porous structure is formed by adding reactive monomers to the mixture and allowing the monomers to polymerize, with the supramolecular structure serving as a template. The resulting solid structure has a shape that is complementary to the shape of the supramolecular structure and has cavities that are the mirror image of the imprint group. Similarly, molecularly imprinted particles may be made by using the surfactant to create a water-in-oil microemulsion wherein the imprint groups are exposed to the water phase.Type: GrantFiled: January 8, 2003Date of Patent: March 30, 2004Assignee: The United States of America as represented by the Secretary of the NavyInventors: Michael A. Markowitz, Paul E. Schoen, Bruce P. Gaber, Banahalli R. Ratna, Paul R. Kust, David C. Turner, Douglas S. Clark, Jonathan S. Dordick
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Patent number: 6660780Abstract: A method of making a molecularly imprinted porous structure makes use of a surfactant analog of the molecule to be imprinted that has the imprint molecule portion serving as the surfactant headgroup. The surfactant analog is allowed to self-assemble in a mixture to create at least one supramolecular structure having exposed imprint groups. The imprinted porous structure is formed by adding reactive monomers to the mixture and allowing the monomers to polymerize, with the supramolecular structure serving as a template. The resulting solid structure has a shape that is complementary to the shape of the supramolecular structure and has cavities that are the mirror image of the imprint group. Similarly, molecularly imprinted particles may be made by using the surfactant to create a water-in-oil microemulsion wherein the imprint groups are exposed to the water phase.Type: GrantFiled: November 27, 2002Date of Patent: December 9, 2003Assignee: The United States of America as represented by the Secretary of the NavyInventors: Michael A. Markowitz, Paul E. Schoen, Bruce P. Gaber, Banahalli R. Ratna, Paul R. Kust, David C. Turner, Douglas S. Clark, Jonathan S. Dordick
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Publication number: 20030191205Abstract: A method of making a molecularly imprinted porous structure makes use of a surfactant analog of the molecule to be imprinted that has the imprint molecule portion serving as the surfactant headgroup. The surfactant analog is allowed to self-assemble in a mixture to create at least one supramolecular structure having exposed imprint groups. The imprinted porous structure is formed by adding reactive monomers to the mixture and allowing the monomers to polymerize, with the supramolecular structure serving as a template. The resulting solid structure has a shape that is complementary to the shape of the supramolecular structure and has cavities that are the mirror image of the imprint group. Similarly, molecularly imprinted particles may be made by using the surfactant to create a water-in-oil microemulsion wherein the imprint groups are exposed to the water phase.Type: ApplicationFiled: November 27, 2002Publication date: October 9, 2003Inventors: Michael A. Markowitz, Paul E. Schoen, Bruce P. Gaber, Banahalli R. Ratna, Paul R. Kust, David C. Turner, Douglas S. Clark, Jonathan S. Dordick