Abstract: The invention relates to a sample retrieval apparatus of particular benefit in the field of molecular biology. The apparatus permits the rapid collection of numerous specified fractions of samples: such as DNA, RNA or protein, that are separated by gel electrophoresis; or microorganisms grown on agar plates. The apparatus is capable of multiple sample retrieval from gels without cross-sample contamination from previously excised samples. Specifically, the sample retrieval apparatus is able to engage a cutting tip, cut a desired spot, band or plaque from a gel, deposit the desired band or plaque into a container, such as a multi-well plate for processing, and disengage the used cutting tip. The apparatus is then able to repeat this process many times to facilitate rapid and accurate processing of multiple bands or plaques from a single gel using different cutting tips for each sample retrieval.