Patents by Inventor Jonathan SEMO

Jonathan SEMO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MSC-NTF SPECIFIC EXOSOMES AND USE THEREOF
    Publication number: 20250127819
    Abstract: Provided herein are highly-characterized isolated exosomes, methods to produce such exosomes, and methods for the use of such exosomes in treating diseases such as neurodegenerative diseases.
    Type: Application
    Filed: December 16, 2024
    Publication date: April 24, 2025
    Applicant: BRAINSTORM CELL THERAPEUTICS LTD.
    Inventors: Revital ARICHA, Haggai KASPI, Jonathan SEMO, Yael GOTHELF
  • MSC-NTF specific exosomes and use thereof
    Patent number: 12233092
    Abstract: Provided herein are highly-characterized isolated exosomes, methods to produce such exosomes, and methods for the use of such exosomes in treating diseases such as neurodegenerative diseases.
    Type: Grant
    Filed: April 10, 2019
    Date of Patent: February 25, 2025
    Assignee: BRAINSTORM CELL THERAPEUTICS LTD.
    Inventors: Revital Aricha, Haggai Kaspi, Jonathan Semo, Yael Gothelf
  • METHODS OF GENERATING MESENCHYAL STEM CELLS WHICH SECRETE NEUROTROPHIC FACTORS IN A BIOREACTOR SYSTEM
    Publication number: 20240327795
    Abstract: The disclosure relates to a method for generating cells which secrete neurotrophic factors (NTFs) in a functionally closed and automated hollow-fiber bioreactor system comprising inducing differentiation of a population of undifferentiated mesenchymal stem cells (MSCs) in a differentiating medium supplemented with ascorbic acid. The disclosure further relates to a method of treating a disease for which administration of neurotrophic factor is beneficial and to a pharmaceutical composition including the described cells.
    Type: Application
    Filed: July 5, 2022
    Publication date: October 3, 2024
    Applicant: BRAINSTORM CELL THERAPEUTICS LTD.
    Inventors: Yossef LEVY, Jonathan SEMO, Lena ELSTER KHOMSKY, Keren MIZRAHI
  • METHODS AND COMPOSITIONS FOR TREATING LUNG CONDITIONS
    Publication number: 20230310507
    Abstract: The present invention provides compositions comprising mesenchymal stem cells (MSCs) and/or exosomes derived therefrom, mesenchymal stem cells secreting neurotrophic factors (MSC-NTFs) and/or exosomes derived therefrom, and methods for their use in treating adverse lung conditions, such as Coronavirus-related acute respiratory distress syndrome (ARDS).
    Type: Application
    Filed: July 20, 2021
    Publication date: October 5, 2023
    Applicant: BRAINSTORM CELL THERAPEUTICS LTD.
    Inventors: Chaim LEBOVITS, Revital ARICHA, Yossef LEVY, Ralph KERN, Haggai KASPI, Jonathan SEMO
  • CELL-TYPE SPECIFIC EXOSOMES AND USE THEREOF
    Publication number: 20210030807
    Abstract: Provided herein are highly-characterized isolated exosomes, methods to produce such exosomes, and methods for the use of such exosomes in treating diseases such as neurodegenerative diseases.
    Type: Application
    Filed: April 10, 2019
    Publication date: February 4, 2021
    Applicant: BRAINSTORM CELL THERAPEUTICS LTD.
    Inventors: Revital ARICHA, Haggai KASPI, Jonathan SEMO, Yael GOTHELF