Patents by Inventor Jonathan Silberg

Jonathan Silberg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190135878
    Abstract: Engineered protein electron carriers, microorganisms expressing the same, and methods detecting regulated electron flow are described.
    Type: Application
    Filed: November 9, 2018
    Publication date: May 9, 2019
    Applicant: WILLIAM MARSH RICE UNIVERSITY
    Inventors: Jonathan Silberg, Joshua T. Atkinson, Ian J. Campbell, George N. Bennett
  • Patent number: 10047128
    Abstract: The present invention is a peptide lock that comprises at least one peptide that is genetically encoded into the Adeno-associated virus (AAV) capsid that block biologically active domains on the virus capsid surface. The peptide lock, can be processed by biological enzymes to restore biological behavior of the capsid-displayed domains, thus ‘decoding the lock’ or opening the lock. A method of forming the peptide lock comprises providing at least one peptide, providing an Adeno-associated virus capsid and genetically inserting the at least one peptide into the Adeno-associated virus capsid to block the biologically active domains on the virus capsid surface.
    Type: Grant
    Filed: April 29, 2013
    Date of Patent: August 14, 2018
    Assignee: WILLIAM MARSH RICE UNIVERSITY
    Inventors: Justin Judd, Junghae Suh, Jonathan Silberg
  • Publication number: 20160194683
    Abstract: Microbial biosensors that generate gas outputs in hard-to-image materials using exogenous methyl halide transferase (WIT) genes. By varying the promoter that is fused to the MHT gene, biosensors for different triggers can be made.
    Type: Application
    Filed: March 21, 2016
    Publication date: July 7, 2016
    Inventors: Jonathan SILBERG, Caroline A. MASIELLO, Hsiao-Ying CHENG
  • Publication number: 20130330766
    Abstract: The present invention is a peptide lock that comprises at least one peptide that is genetically encoded into the Adeno-associated virus (AAV) capsid that block biologically active domains on the virus capsid surface. The peptide lock, can be processed by biological enzymes to restore biological behavior of the capsid-displayed domains, thus ‘decoding the lock’ or opening the lock. A method of forming the peptide lock comprises providing at least one peptide, providing an Adeno-associated virus capsid and genetically inserting the at least one peptide into the Adeno-associated virus capsid to block the biologically active domains on the virus capsid surface.
    Type: Application
    Filed: April 29, 2013
    Publication date: December 12, 2013
    Applicant: William Marsh Rice University
    Inventors: Justin Judd, Junghae Suh, Jonathan Silberg
  • Patent number: 8236491
    Abstract: A protein fragment complementation assay for thermophiles is provided wherein a thermophilic bacteria having a temperature-sensitive adenylate kinase is transformed with one or more vectors having sequences encoding a first test peptide operatively fused to a first portion of a thermostable adenylate and a second test peptide operatively fused to a second portion of the thermostable adenylate kinase. Association of the first and second test peptides allows association of the first and second portions of the thermostable adenylate kinase and growth of the thermophilic bacteria at a temperature greater than 70° C.
    Type: Grant
    Filed: September 23, 2010
    Date of Patent: August 7, 2012
    Assignee: William Marsh Rice University
    Inventors: Jonathan Silberg, Peter Q. Nguyen
  • Publication number: 20110287462
    Abstract: A protein fragment complementation assay for thermophiles is provided wherein a thermophilic bacteria having a temperature-sensitive adenylate kinase is transformed with one or more vectors having sequences encoding a first test peptide operatively fused to a first portion of a thermostable adenylate and a second test peptide operatively fused to a second portion of the thermostable adenylate kinase. Association of the first and second test peptides allows association of the first and second portions of the thermostable adenylate kinase and growth of the thermophilic bacteria at a temperature greater than 70° C.
    Type: Application
    Filed: September 23, 2010
    Publication date: November 24, 2011
    Applicant: RICE UNIVERSITY
    Inventors: Jonathan SILBERG, Peter Q. NGUYEN