Patents by Inventor Jonathan Silverberg
Jonathan Silverberg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9814775Abstract: A composition comprising a high purity cannabinoid, an acid, and a pharmaceutically-acceptable solvent achieves room temperature stability for over 24 months. The acid improves the stability of the composition and the solvent enhances the solubility of the acid, thereby allowing the acid to have an improved stabilizing effect on the highly pure cannabinoid. Preferably, the solvent is an alcohol and, more preferably, the composition contains an oil. A method for making the composition includes combining the cannabinoid and the solvent and evaporating a portion of the solvent, along with adding an acid to the composition, before, during, or after the evaporating step. A method for making and storing the composition includes storing the composition in a manner adapted to maintain its stability. Pharmaceutical dosage forms include a formulated composition, such as having the oil. A method of treating a subject comprises administering to the subject the dosage form.Type: GrantFiled: December 18, 2014Date of Patent: November 14, 2017Assignee: Johnson Matthey Public Limited CompanyInventors: Ronald Rossi, Lee Jonathan Silverberg, Robert Hogan, Ramesh M. Shah
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Publication number: 20150165030Abstract: A composition comprising a high purity cannabinoid, an acid, and a pharmaceutically-acceptable solvent achieves room temperature stability for over 24 months. The acid improves the stability of the composition and the solvent enhances the solubility of the acid, thereby allowing the acid to have an improved stabilizing effect on the highly pure cannabinoid. Preferably, the solvent is an alcohol and, more preferably, the composition contains an oil. A method for making the composition includes combining the cannabinoid and the solvent and evaporating a portion of the solvent, along with adding an acid to the composition, before, during, or after the evaporating step. A method for making and storing the composition includes storing the composition in a manner adapted to maintain its stability. Pharmaceutical dosage forms include a formulated composition, such as having the oil. A method of treating a subject comprises administering to the subject the dosage form.Type: ApplicationFiled: December 18, 2014Publication date: June 18, 2015Inventors: Ronald ROSSI, Lee Jonathan Silverberg, Robert Hogan, Ramesh M. Shah
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Patent number: 8980940Abstract: A composition comprising a high purity cannabinoid, an acid, and a pharmaceutically-acceptable solvent achieves room temperature stability for over 24 months. The acid improves the stability of the composition and the solvent enhances the solubility of the acid, thereby allowing the acid to have an improved stabilizing effect on the highly pure cannabinoid. Preferably, the solvent is an alcohol and, more preferably, the composition contains an oil. A method for making the composition includes combining the cannabinoid and the solvent and evaporating a portion of the solvent, along with adding an acid to the composition, before, during, or after the evaporating step. A method for making and storing the composition includes storing the composition in a manner adapted to maintain its stability. Pharmaceutical dosage forms include a formulated composition, such as having the oil. A method of treating a subject comprises administering to the subject the dosage form.Type: GrantFiled: November 22, 2011Date of Patent: March 17, 2015Assignee: Johnson Matthey Public Limited CompanyInventors: Ronald Rossi, Lee Jonathan Silverberg, Robert Hogan, Ramesh M. Shah
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Patent number: 8906956Abstract: A composition comprising a tetrahydrocannabinol compound, a solvent and an acid, wherein the tetrahydrocannabinol compound may be ?8 tetrahydrocannabinol, (?)-?9-trans-tetrahydrocannabinol or a side chain alkyl derivative of either compound, the solvent may be an oil or C1-C4 alcohol (e.g. sesame oil or ethanol), and the acid may be an organic acid or a mineral acid.Type: GrantFiled: June 7, 2013Date of Patent: December 9, 2014Assignee: Johnson Matthey Public Limited CompanyInventors: Ronald Rossi, Lee Jonathan Silverberg, Robert Hogan, Ramesh M. Shah
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Publication number: 20130345299Abstract: A composition comprising a tetrahydrocannabinol compound, a solvent and an acid, wherein the tetrahydrocannabinol compound may be ?8 tetrahydrocannabinol, (?)-?9-trans-tetrahydrocannabinol or a side chain alkyl derivative of either compound, the solvent may be an oil or C1-C4 alcohol (e.g. sesame oil or ethanol), and the acid may be an organic acid or a mineral acid.Type: ApplicationFiled: June 7, 2013Publication date: December 26, 2013Applicant: Johnson Matthey Public Limited CompanyInventors: Ronald Rossi, Lee Jonathan Silverberg, Robert Hogan, Ramesh M. Shah
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Patent number: 8476312Abstract: A composition comprising a tetrahydrocannabinol compound, a solvent and an acid, wherein the tetrahydrocannabinol compound may be ?8 tetrahydrocannabinol, (?)-?9-trans-tetrahydrocannabinol or a side chain alkyl derivative of either compound, the solvent may be an oil or C1-C4 alcohol (e.g. sesame oil or ethanol), and the acid may be an organic acid or a mineral acid.Type: GrantFiled: August 28, 2012Date of Patent: July 2, 2013Assignee: Johnson Matthey Public Limited CompanyInventors: Ronald Rossi, Lee Jonathan Silverberg, Robert Hogan, Ramesh M. Shah
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Publication number: 20120322866Abstract: A composition comprising a tetrahydrocannabinol compound, a solvent and an acid, wherein the tetrahydrocannabinol compound may be ?8 tetrahydrocannabinol, (?)-?9-trans-tetrahydrocannabinol or a side chain alkyl derivative of either compound, the solvent may be an oil or C1-C4 alcohol (e.g. sesame oil or ethanol), and the acid may be an organic acid or a mineral acid.Type: ApplicationFiled: August 28, 2012Publication date: December 20, 2012Applicant: JOHNSON MATTHEY PUBLIC LIMITED COMPANYInventors: Ronald Rossi, Lee Jonathan Silverberg, Robert Hogan, Ramesh M. Shah
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Publication number: 20120263785Abstract: A composition comprising a high purity cannabinoid, an acid, and a pharmaceutically-acceptable solvent achieves room temperature stability for over 24 months. The acid improves the stability of the composition and the solvent enhances the solubility of the acid, thereby allowing the acid to have an improved stabilizing effect on the highly pure cannabinoid. Preferably, the solvent is an alcohol and, more preferably, the composition contains an oil. A method for making the composition includes combining the cannabinoid and the solvent and evaporating a portion of the solvent, along with adding an acid to the composition, before, during, or after the evaporating step. A method for making and storing the composition includes storing the composition in a manner adapted to maintain its stability. Pharmaceutical dosage forms include a formulated composition, such as having the oil. A method of treating a subject comprises administering to the subject the dosage form.Type: ApplicationFiled: November 22, 2011Publication date: October 18, 2012Applicant: JOHNSON MATTHEY PUBLIC LIMITED COMPANYInventors: Ronald Rossi, Lee Jonathan Silverberg, Robert Hogan, Ramesh M. Shah
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Publication number: 20120010279Abstract: A composition comprising a tetrahydrocannabinol compound, a solvent and an acid, wherein the tetrahydrocannabinol compound may be ?8 tetrahydrocannabinol, (?)-?9-trans-tetrahydrocannabinol or a side chain alkyl derivative of either compound, the solvent may be an oil or C1-C4 alcohol (e.g. sesame oil or ethanol), and the acid may be an organic acid or a mineral acid.Type: ApplicationFiled: September 20, 2011Publication date: January 12, 2012Applicant: Johnson Mathey Public Limited CompanyInventors: Ronald Rossi, Lee Jonathan Silverberg, Robert Hogan, Ramesh M. Shah
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Patent number: 8039509Abstract: A composition comprising a tetrahydrocannabinol compound, a solvent and an acid, wherein the tetrahydrocannabinol compound may be ?8 tetrahydrocannabinol, (?)-?9-trans-tetrahydrocannabinol or a side chain alkyl derivative of either compound, the solvent may be an oil or C1-C4 alcohol (e.g. sesame oil or ethanol), and the acid may be an organic acid or a mineral acid.Type: GrantFiled: November 10, 2006Date of Patent: October 18, 2011Assignee: Johnson Matthey Public Limited CompanyInventors: Ronald Rossi, Lee Jonathan Silverberg, Robert Hogan, Ramesh M. Shah
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Publication number: 20080139644Abstract: A composition comprising a tetrahydrocannabinol compound, a solvent and an acid, wherein the tetrahydrocannabinol compound may be ?8 tetrahydrocannabinol, (?)-?9-trans-tetrahydrocannabinol or a side chain alkyl derivative of either compound, the solvent may be an oil or C1-C4 alcohol (e.g. sesame oil or ethanol), and the acid may be an organic acid or a mineral acid.Type: ApplicationFiled: November 10, 2006Publication date: June 12, 2008Inventors: Ronald Rossi, Lee Jonathan Silverberg, Robert Hogan, Ramesh M. Shah
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Patent number: 7186850Abstract: The present invention relates to a process for the production of compound (A) comprising reacting compound (B) with compound (C). A further ring closure reaction may be necessary. The invention further relates to certain novel compounds of formula (B).Type: GrantFiled: May 9, 2002Date of Patent: March 6, 2007Assignee: Johnson Matthey Public Limited CompanyInventor: Lee Jonathan Silverberg
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Patent number: 6867335Abstract: The present invention relates to process wherein (+)-2-carene epoxide is coupled with a compound X—Y that contains nucleophilic and electrophilic moieties, to produce a compound of formula (5). The reaction mixture consists essentially of a source of (+)-2-carene epoxide, compound X—Y, optionally an inert solvent and optionally a pH buffer. No acid catalyst is used in the process.Type: GrantFiled: May 9, 2002Date of Patent: March 15, 2005Assignee: Johnson Matthey Public Limited CompanyInventors: Michael Casner, Theodore Maurice Resnick, Lee Jonathan Silverberg
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Publication number: 20040249174Abstract: The present invention relates to a process for the production of compound (A) comprising reacting compound (B) with compound (C). A further ring closure reaction may be necessary. The invention further relates to certain novel compounds of formula (B).Type: ApplicationFiled: August 5, 2004Publication date: December 9, 2004Inventor: Lee Jonathan Silverberg
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Publication number: 20040210076Abstract: The present invention relates to process wherein (+)-2-carene epoxide is coupled with a compound X-Y that contains nucleophilic and electrophilic moieties, to produce a compound of formula (5). The reaction mixture consists essentially of a source of (+)-2-carene epoxide, compound X-Y, optionally an inert solvent and optionally a pH buffer. No acid catalyst is used in the process.Type: ApplicationFiled: June 7, 2004Publication date: October 21, 2004Inventors: Michael Casner, Theodore Maurice Resnick, Lee Jonathan Silverberg
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Publication number: 20030069683Abstract: A traffic monitoring system for monitoring traffic including a population of users bearing a multiplicity of mobile communication devices, and methods useful for monitoring traffic, the system including a mobile communication network interface receiving, from at least one communication network serving the multiplicity of mobile communication devices, and storing, location information characterizing at least some of the multiplicity of mobile communication devices, and a traffic monitor operative to compute at least one traffic-characterizing parameter on the basis of the location information.Type: ApplicationFiled: October 10, 2002Publication date: April 10, 2003Inventors: Dror Lapidot, Jonathan Silverberg
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Patent number: 6490519Abstract: A traffic monitoring system for monitoring traffic including a population of users bearing a multiplicity of mobile communication devices, and methods useful for monitoring traffic, the system including a mobile communication network interface receiving, from at least one communication network serving the multiplicity of mobile communication devices, and storing, location information characterizing at least some of the multiplicity of mobile communication devices, and a traffic monitor operative to compute at least one traffic-characterizing parameter on the basis of the location information.Type: GrantFiled: September 25, 2000Date of Patent: December 3, 2002Assignee: Decell, inc.Inventors: Dror Lapidot, Jonathan Silverberg