Patents by Inventor Jonathan Sockolosky

Jonathan Sockolosky has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ENGINEERED PROTEINS TO ENHANCE SENSITIVITY OF A CELL TO IL-2
    Publication number: 20240092855
    Abstract: Engineered proteins, polynucleotides encoding such proteins, and methods of use thereof are provided, which engineered proteins enhance the sensitivity of a cell to IL-2.
    Type: Application
    Filed: September 1, 2023
    Publication date: March 21, 2024
    Inventors: Kenan Christopher Garcia, Sean Parker, Jonathan Sockolosky, Michael Hollander
  • Engineered proteins to enhance sensitivity of a cell to IL-2
    Patent number: 11780899
    Abstract: Engineered proteins, polynucleotides encoding such proteins, and methods of use thereof are provided, which engineered proteins enhance the sensitivity of a cell to IL-2.
    Type: Grant
    Filed: December 5, 2018
    Date of Patent: October 10, 2023
    Assignees: The Board of Trustees of the Leland Stanford Junior University, Parker Institute for Cancer Immunotherapy
    Inventors: Kenan Christopher Garcia, Sean Parker, Jonathan Sockolosky, Michael Hollander
  • BIOLOGICALLY RELEVANT ORTHOGONAL CYTOKINE/RECEPTOR PAIRS
    Publication number: 20220354893
    Abstract: Engineered orthogonal cytokine receptor/ligand pairs, and methods of use thereof, are provided.
    Type: Application
    Filed: July 26, 2022
    Publication date: November 10, 2022
    Inventors: Kenan Christopher Garcia, Jonathan Sockolosky, David Baker, Chris King
  • Biologically relevant orthogonal cytokine/receptor pairs
    Patent number: 11439664
    Abstract: Engineered orthogonal cytokine receptor/ligand pairs, and methods of use thereof, are provided.
    Type: Grant
    Filed: February 28, 2019
    Date of Patent: September 13, 2022
    Assignees: The Board of Trustees of the Leland Stanford Junior University, UNIVERSITY OF WASHINGTON
    Inventors: Kenan Christopher Garcia, Jonathan Sockolosky, David Baker, Chris King
  • ANTI-HER2 POLYPEPTIDES AND METHODS OF USE THEREOF
    Publication number: 20220002436
    Abstract: The present disclosure relates to anti-HER2 constructs, such as Fc polypeptide dimer-antibody variable region fusion proteins, that cross the BBB and bind to HER2 in the brain parenchyma. In some embodiments, the anti-HER2 constructs (e.g., Fc polypeptide dimer-antibody variable region fusion proteins) retain effector function upon binding to HER2, but do not substantially deplete reticulocytes in vivo. The present disclosure also relates to methods for transcytosing an anti-HER2 antibody variable region across the BBB and treating HER2-positive cancers and metastatic lesions thereof.
    Type: Application
    Filed: February 18, 2021
    Publication date: January 6, 2022
    Applicant: Denali Therapeutics Inc.
    Inventors: Mark S. Dennis, Wanda Kwan, Joseph W. Lewcock, Jonathan Sockolosky, Joy Yu Zuchero
  • BIOLOGICALLY RELEVANT ORTHOGONAL CYTOKINE/RECEPTOR PAIRS
    Publication number: 20210069243
    Abstract: Engineered orthogonal cytokine receptor/ligand pairs, and methods of use thereof, are provided.
    Type: Application
    Filed: November 19, 2020
    Publication date: March 11, 2021
    Inventors: Kenan Christopher Garcia, Jonathan Sockolosky, Lora Picton
  • BIOLOGICALLY RELEVANT ORTHOGONAL CYTOKINE/RECEPTOR PAIRS
    Publication number: 20210060068
    Abstract: Engineered orthogonal cytokine receptor/ligand pairs, and methods of use thereof, are provided.
    Type: Application
    Filed: March 8, 2019
    Publication date: March 4, 2021
    Inventors: Kenan Christopher Garcia, Jonathan Sockolosky, Lora Picton
  • Biologically relevant orthogonal cytokine/receptor pairs
    Patent number: 10869887
    Abstract: Engineered orthogonal cytokine receptor/ligand pairs, and methods of use thereof, are provided.
    Type: Grant
    Filed: March 9, 2018
    Date of Patent: December 22, 2020
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Kenan Christopher Garcia, Jonathan Sockolosky, Lora Picton
  • Engineered Proteins to Enhance Sensitivity of A Cell to IL-2
    Publication number: 20200385438
    Abstract: Engineered proteins, polynucleotides encoding such proteins, and methods of use thereof are provided, which engineered proteins enhance the sensitivity of a cell to IL-2.
    Type: Application
    Filed: December 5, 2018
    Publication date: December 10, 2020
    Inventors: Kenan Christopher Garcia, Sean Parker, Jonathan Sockolosky, Michael Hollander
  • BIOLOGICALLY RELEVANT ORTHOGONAL CYTOKINE/RECEPTOR PAIRS
    Publication number: 20190183933
    Abstract: Engineered orthogonal cytokine receptor/ligand pairs, and methods of use thereof, are provided.
    Type: Application
    Filed: February 28, 2019
    Publication date: June 20, 2019
    Inventors: Kenan Christopher Garcia, Jonathan Sockolosky, David Baker, Chris King
  • BIOLOGICALLY RELEVANT ORTHOGONAL CYTOKINE/RECEPTOR PAIRS
    Publication number: 20180228842
    Abstract: Engineered orthogonal cytokine receptor/ligand pairs, and methods of use thereof, are provided.
    Type: Application
    Filed: March 9, 2018
    Publication date: August 16, 2018
    Inventors: Kenan Christopher Garcia, Jonathan Sockolosky, David Baker, Chris King