Abstract: A computer system displays a first user interface object and a first control element with a first appearance that is associated with performing a first operation with respect to the first user interface object, in a first view of a three-dimensional environment. The computer system detects a first gaze input that is directed to the first control element, and in response, updates an appearance of the first control element from to a second appearance that is different from the first appearance. While displaying the first control element with the second appearance, the computer system detects a first user input directed to the first control element, and in accordance with a determination that the first user input meets first criteria, updates the appearance of the first control element from the second appearance to a third appearance that is different from the first appearance and the second appearance.

Abstract: In some embodiments, a computer system applies a time of day setting to a virtual environment. In some embodiments, the time of day setting is updated based on an event. In some embodiments, a computer system displays content in an expanded display mode. In some embodiments, computer systems join a communication session while maintaining display of respective environments. In some embodiments, a computer system moves a portal based on user movement. In some embodiments, computer systems share a virtual environment. Computer systems can display media with simulated lighting. Computer systems can share an environment. In some embodiments, a computer system selects a position relative to content. A computer system can present representations of communication session participants based on content. A computer system can present user interfaces to control visual appearances of an environment including media. Computer systems can change an appearance of an environment based on environmental modes.

Abstract: The present invention relates to a method for ex-vivo or in-vitro evaluation of an effect of a molecule of interest on at least one molecular marker in a dosed biological sample. The method of the invention is based on the segmentation of a biological sample based on the concentration of a molecule of interest and the comparison of molecular changes associated to the presence of the molecule of interest within different parts/segments of a same biological sample or between different biological samples, which may comprise different amounts of said molecule of interest and/or different molecules of interest.

Abstract: Disclosed is a method for characterizing a sample by mass spectrometry imaging (MSI) according to which a spatial arrangement of at least one ion in the sample is characterized from imaging data associated with the ion, in terms of morphology and/or texture.

Abstract: The invention relates to a method for preparing a dilution range of at least one standard molecule for a tissue, whereby a tissue homogenate is used, to which the standard molecule is added, the resulting mixture being conditioned and sliced before the analysis of a slice of said tissue. The invention also relates to a method for detecting and quantifying at least one target molecule in at least one tissue using a standard range according to the invention.

Abstract: Disclosed is a method for characterizing a sample by mass spectrometry imaging (MSI) according to which a spatial arrangement of at least one ion in the sample is characterized from imaging data associated with the ion, in terms of morphology and/or texture.

Abstract: The invention relates to a method for evaluating whether a molecule of interest binds or is incorporated in at least one target tissue, comprising visualizing and comparing the distribution of the molecule of interest and of at least one control compound within the target tissue or on the target tissue surface of at least one animal that has previously received the molecule of interest and/or the control compound. Advantageously, the distribution of the molecule of interest is visualized and compared with the distribution of positive and negative compounds using mass spectrometry imaging on the surface of the target tissue.

Abstract: The invention relates to a method for identifying and quantifying by mass spectrometry at least one target analyte in a sample, comprising the following steps: a) depositing the sample to be analyzed on a support; b) analyzing the sample by mass spectrometry, so as to obtain the mass spectrum of the target analyte in said sample; c) weighting a signal associated with the mass spectrum of the target analyte in said sample by a extinction coefficient (TEC) specific to the target analyte and to the sample; and d) using the weighted signal of the target analyte to determine the quantity of target analyte in the sample.

Abstract: The present invention relates to the field of the detection of molecules of interest in a sample, preferably by mass spectrometry. The present invention concerns a label compound, a molecule labeled with said compound (a conjugate), a method of detection of a molecule of interest (a target molecule) in a sample involving said conjugate, a kit to implement said method and a process for the preparation of the label.

Abstract: The invention relates to a method for evaluating if a molecule of interest binds or is incorporated in, at least one target tissue comprising visualizing and comparing the distribution of the molecule of interest and of at least one control compound within the target tissue or on the target tissue surface of at least one animal that has previously received the molecule of interest and/or the control compound. Advantageously, the distribution of the molecule of interest is visualized and compared with the distribution of positive and negative compounds using mass spectrometry imaging on the surface of the target tissue.

Abstract: The invention relates to a method for identifying and quantifying by mass spectrometry imaging at least one target analyte in a tissue sample, comprising the following steps: a) depositing the tissue sample to be analyzed on a support; b) analyzing the sample by mass spectrometry imaging, so as to obtain the mass spectrum of the target analyte in said tissue sample; c) weighting a signal associated with the mass spectrum of the target analyte in said tissue sample by a tissue extinction coefficient (TEC) specific to the target analyte and to the tissue sample which is obtained by using a control tissue sample; and d) using the weighted signal of the target analyte to determine the quantity of target analyte in the tissue sample.

Abstract: The invention relates to a method for preparing a dilution range of at least one standard molecule for a tissue, whereby a tissue homogenate is used, to which the standard molecule is added, the resulting mixture being conditioned and sliced before the analysis of a slice of said tissue. The invention also relates to a method for detecting and quantifying at least one target molecule in at least one tissue using a standard range according to the invention.

Abstract: The invention relates to a method for identifying and quantifying by mass spectrometry at least one target molecule in a sample, comprising the following steps: a) depositing the sample to be analyzed on a support; b) analyzing the sample by mass spectrometry, so as to obtain the mass spectrum of the target molecule in said sample; c) weighting a signal associated with the mass spectrum of the target molecule in said sample by a extinction coefficient (TEC) specific to the target molecule and to the sample; and d) using the weighted signal of the target molecule to determine the quantity of target molecule in the sample.