Patents by Inventor Jonathan Steven Alexander

Jonathan Steven Alexander has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 3D PRINTED POLYVINYL ALCOHOL MEDICAL DEVICES AND METHODS OF ACTIVATION
    Publication number: 20210236699
    Abstract: A medical device comprising a structure formed of polyvinyl alcohol.
    Type: Application
    Filed: January 30, 2020
    Publication date: August 5, 2021
    Inventors: Jonathan Steven ALEXANDER, Christen J. Boyer
  • Drug delivery system and method for the treatment of neuro-degenerative disease
    Publication number: 20200397701
    Abstract: Embodiments of the present invention are directed to drug delivery systems, dosage forms and methods for the intranasal administration of Bryostatins for the treatment of neuro-degenerative diseases. Inventions of the present application are directed to the treatment of neuro-degenerative diseases such as Hutchinson Disease, Parkinson's disease, Down syndrome and Alzheimer's disease.
    Type: Application
    Filed: November 22, 2019
    Publication date: December 24, 2020
    Inventors: Trevor Percival Castor, Jonathan Steven Alexander
  • Transplantation therapies
    Patent number: 10723744
    Abstract: Embodiments of the present invention are directed to methods and dosage forms for treating inflammation and rejection in transplantation injuries with Bryostatin-1, Bryostatin-1 analogs and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: June 8, 2018
    Date of Patent: July 28, 2020
    Inventors: Jonathan Steven Alexander, April C. Carpenter, Trevor Percival Castor
  • Transplantation Therapies
    Publication number: 20200199146
    Abstract: Embodiments of the present invention are directed to methods and dosage forms for treating inflammation and rejection in transplantation injuries with Bryostatin-1, Bryostatin-1 analogs and pharmaceutically acceptable salts thereof.
    Type: Application
    Filed: March 5, 2020
    Publication date: June 25, 2020
    Inventors: Jonathan Steven Alexander, April C. Carpenter, Trevor Percival Castor
  • Transplantation Therapies
    Publication number: 20200199145
    Abstract: Embodiments of the present invention are directed to methods and dosage forms for treating inflammation and rejection in transplantation injuries with Bryostatin-1, Bryostatin-1 analogs and pharmaceutically acceptable salts thereof.
    Type: Application
    Filed: March 5, 2020
    Publication date: June 25, 2020
    Inventors: Jonathan Steven Alexander, April C. Carpenter, Trevor Percival Castor
  • 3D printed polyvinyl alcohol medical devices and methods of activation
    Patent number: 10537659
    Abstract: A medical device comprising a structure formed of polyvinyl alcohol.
    Type: Grant
    Filed: September 29, 2017
    Date of Patent: January 21, 2020
    Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventors: Jonathan Steven Alexander, Christen J. Boyer
  • Drug delivery system and method for the treatment of neuro-degenerative disease
    Patent number: 10485766
    Abstract: Embodiments of the present invention are directed to the oral administration of Bryostatins for the treatment of neuro-degenerative disease.
    Type: Grant
    Filed: May 18, 2015
    Date of Patent: November 26, 2019
    Assignees: Aphios Corporation, Board of Supervisors of the Louisiana State University and Agricultural and Mechanical College
    Inventors: Trevor Percival Castor, Jonathan Steven Alexander, Geoffrey Purdum, J. David Rios, Lisa M. Schrott, Theodore A. Tyler, Maria I. Vizcaino
  • 3D PRINTED POLYVINYL ALCOHOL MEDICAL DEVICES AND METHODS OF ACTIVATION
    Publication number: 20190099516
    Abstract: A medical device comprising a structure formed of polyvinyl alcohol.
    Type: Application
    Filed: September 29, 2017
    Publication date: April 4, 2019
    Inventors: Jonathan Steven ALEXANDER, Christian J. Boyer
  • TRANSPLANTATION THERAPIES
    Publication number: 20180291033
    Abstract: Embodiments of the present invention are directed to methods and dosage forms for treating inflammation and rejection in transplantation injuries with Bryostatin-1, Bryostatin-1 analogs and pharmaceutically acceptable salts thereof.
    Type: Application
    Filed: June 8, 2018
    Publication date: October 11, 2018
    Inventors: Jonathan Steven Alexander, April C. Carpenter, Trevor Percival Castor
  • Transplantation therapies
    Patent number: 9994585
    Abstract: Embodiments of the present invention are directed to methods and dosage forms for treating inflammation and rejection in transplantation injuries with Bryostatin-1, Bryostatin-1 analogs and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: September 30, 2014
    Date of Patent: June 12, 2018
    Assignee: Aphios Corporation
    Inventors: Jonathan Steven Alexander, April C. Carpenter, Trevor Percival Castor
  • DRUG DELIVERY SYSTEM AND METHOD FOR THE TREATMENT OF NEURO-DEGENERATIVE DISEASE
    Publication number: 20150246000
    Abstract: Embodiments of the present invention are directed to the oral administration of Bryostatins for the treatment of neuro-degenerative disease.
    Type: Application
    Filed: May 18, 2015
    Publication date: September 3, 2015
    Inventors: Trevor Percival Castor, Jonathan Steven Alexander, Geoffrey Purdum, J. David Rios, Lisa M. Schrott, Theodore A. Tyler, Maria I. Vizcaino
  • Drug delivery system and method for the treatment of neuro-degenerative disease
    Patent number: 9034347
    Abstract: Embodiments of the present invention are directed to the oral administration of Bryostatins for the treatment of neuro-degenerative disease.
    Type: Grant
    Filed: December 19, 2012
    Date of Patent: May 19, 2015
    Assignees: Arphios Corporation, For the Board of Supervisors of Louisiana State University and Agricultural and Mechanical College acting on behalf of Louisiana State University Health Sciences Center at Shreveport
    Inventors: Trevor Percival Castor, Jonathan Steven Alexander, Geoffrey Purdum, J. David Rios, Lisa M. Schrott, Theodore A. Tyler, Maria I. Vizcaino
  • TRANSPLANTATION THERAPIES
    Publication number: 20150094363
    Abstract: Embodiments of the present invention are directed to methods and dosage forms for treating inflammation and rejection in transplantation injuries with Bryostatin-1, Bryostatin-1 analogs and pharmaceutically acceptable salts thereof.
    Type: Application
    Filed: September 30, 2014
    Publication date: April 2, 2015
    Inventors: Jonathan Steven Alexander, April C. Carpenter, Trevor Percival Castor
  • CHRONIC INFLAMMATION AND TRANSPLANTATION
    Publication number: 20120309818
    Abstract: Embodiments of the present invention feature methods for treating inflammatory disease and transplantation characterized in that it includes: (i) the incubation of organs with one or more Bryostatin-1 derivatives under conditions which permits vascular exposure to these compounds prior to or immediately following organ ‘harvesting’, and (ii) intravenous, transdermal, intraperitoneal, intra-alveolar instillation of Bryostatin-1 in vivo during active disease, or during periods of disease remission and (iii) prophylactic administration of Bryostatin-1 to limit the development of GVHD.
    Type: Application
    Filed: January 20, 2012
    Publication date: December 6, 2012
    Inventors: Jonathan Steven ALEXANDER, April C. Carpenter, Trevor Percival Castor
  • Chronic inflammation and transplantation
    Publication number: 20100168219
    Abstract: Neutrophils (PMN) can migrate along gradients of chemoattractants across endothelial monolayers to sites of inflammation and infection. This chemotaxis through endothelial cell borders is involved in several acute and chronic inflammatory diseases, however our understanding of the role of endothelial second messengers in the regulation of leukocyte emigration is still incomplete. We investigated this using an in vitro model of neutrophil migration across human umbilical vein endothelial cells (HUVECs) and human microvascular endothelial cells (HMECs) on cell culture inserts. We report that activation of endothelial protein kinase C (PKC) by both phorbol myristate acetate (PMA) and Bryostatin-1 (a potent PKC? and c activator) can completely abolish neutrophil migration mediated by both endothelial TNF-? stimulation and a leukotriene B4 (LTB4) gradient. PMA protected against LTB4 induced PMN transmigration for at least 24 hours in HMECs and HUVECs.
    Type: Application
    Filed: December 31, 2008
    Publication date: July 1, 2010
    Inventor: Jonathan Steven Alexander