Publication number: 20110130567
Abstract: A process for stereoselective synthesis of a compound of Formula (X) wherein: R1 is an aryl group substituted with one to three substituent groups, wherein each substituent group of R1 is independently C1-C5 alkyl, aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, halogen, carboxy, cyano, or trifluoromethyl, wherein each substituent group of R1 is optionally independently substituted with one to three substituents selected from C1-C3 alkyl, C1-C3 alkoxy, phenyl, and alkoxyphenyl; R2 and R3 are each independently C1-C5 alkyl; R4 is C1-C5 alkyl optionally independently substituted with one to three substituent groups, wherein each substituent group of R4 is independently C1-C3 alkyl, hydroxy, halogen, amino, or oxo; and R5 is a heteroaryl group substituted with one to three substituent groups, wherein each substituent group of R5 is independently C1-C5 alkyl, aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, alkylsulfonylamino, aminosulfonyl, C1-C5 alkylaminosulfonyl, C1-C5 dialky
Type:
Application
Filed:
May 27, 2010
Publication date:
June 2, 2011
Applicant:
BOEHRINGER INGELHEIM INTERNATIONAL GMBH
Inventors:
DANIEL R. FANDRICK, JONATHAN T. REEVES, JINHUA J. SONG, ZHULIN TAN, BO QU, NATHAN K. YEE, SONIA RODRIGUEZ