Patents by Inventor Jonathan Timothy Reeves

Jonathan Timothy Reeves has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Transition metal-catalyzed protodecarboxylation of ?-halo-acrylic acid derivatives
    Patent number: 11046648
    Abstract: The present invention relates to a method for the synthesis of a halo olefin of formula (I) wherein Hal, R1, R2, R3, R4, X and Y are as defined herein, or a salt thereof.
    Type: Grant
    Filed: April 1, 2020
    Date of Patent: June 29, 2021
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Mai Thi Quynh Dang, Thomas Armin Hampel, Sandra Koch, Fredrik Lars Nordstrom, Jonathan Timothy Reeves, Carsten Reichel, Marvin Schoerer, Christian Stange, Ivan N. Volchkov, Li Zhong, Uwe Johannes Zimmermann
  • Transition Metal-catalyzed Protodecarboxylation of alpha-Halo-acrylic Acid Derivatives
    Publication number: 20200231544
    Abstract: The present invention relates to a method for the synthesis of a halo olefin of formula (I) wherein Hal, R1, R2, R3, R4, X and Y are as defined herein, or a salt thereof.
    Type: Application
    Filed: April 1, 2020
    Publication date: July 23, 2020
    Inventors: Mai Thi Quynh DANG, Thomas Armin Hampel, Sandra Koch, Fredrik Lars Nordstrom, Jonathan Timothy Reeves, Carsten Reichel, Marvin Schoerer, Christian Stange, Ivan N. Volchkov, Li Zhong, Uwe Johannes Zimmermann
  • Transition metal-catalyzed protodecarboxylation of alpha-halo-acrylic acid derivatives
    Patent number: 10654803
    Abstract: The present invention relates to a method for the synthesis of a halo olefin of formula (I) wherein Ha1, R1, R2, R3, R4, X and Y are as defined herein, or a salt thereof.
    Type: Grant
    Filed: February 20, 2019
    Date of Patent: May 19, 2020
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Mai Thi Quynh Dang, Thomas Armin Hampel, Sandra Koch, Fredrik Lars Nordstrom, Jonathan Timothy Reeves, Carsten Reichel, Marvin Schoerer, Christian Stange, Ivan N. Volchkov, Li Zhong, Uwe Johannes Zimmermann
  • TRANSITION METAL-CATALYZED PROTODECARBOXYLATION OF ALPHA-HALO-ACRYLIC ACID DERIVATIVES
    Publication number: 20190177273
    Abstract: The present invention relates to a method for the synthesis of a halo olefin of formula (I) wherein Hal, R1, R2, R3, R4, X and Y are as defined herein, or a salt thereof.
    Type: Application
    Filed: February 20, 2019
    Publication date: June 13, 2019
    Inventors: Mai Thi Quynh DANG, Thomas Armin Hampel, Sandra Koch, Fredrik Lars Nordstrom, Jonathan Timothy Reeves, Carsten Reichel, Marvin Schoerer, Christian Stange, Ivan N. Volchkov, Li Zhong, Uwe Johannes Zimmermann
  • Transition metal-catalyzed protocarboxylation of ?-halo-acrylic acid derivatives
    Patent number: 10252994
    Abstract: The present invention relates to a method for the synthesis of a halo olefin of formula (I) wherein Hal, R1, R2, R3, R4, X and Y are as defined herein, or a salt thereof.
    Type: Grant
    Filed: February 22, 2018
    Date of Patent: April 9, 2019
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Mai Thi Quynh Dang, Thomas Armin Hampel, Sandra Koch, Fredrik Lars Nordstrom, Jonathan Timothy Reeves, Carsten Reichel, Marvin Schoerer, Christian Stange, Ivan N. Volchkov, Li Zhong, Uwe Johannes Zimmermann
  • Transition Metal-catalyzed Protocarboxylation of alpha-Halo-acrylic Acid Derivatives
    Publication number: 20180251427
    Abstract: The present invention relates to a method for the synthesis of a halo olefin of formula (I) wherein Hal, R1, R2, R3, R4, X and Y are as defined herein, or a salt thereof.
    Type: Application
    Filed: February 22, 2018
    Publication date: September 6, 2018
    Inventors: Mai Thi Quynh DANG, Thomas Armin HAMPEL, Sandra KOCH, Fredrik Lars NORDSTROM, Jonathan Timothy REEVES, Carsten REICHEL, Marvin SCHOERER, Christian STANGE, Ivan N. VOLCHKOV, Li Zhong, Uwe Johannes ZIMMERMANN
  • Methods for making oxetan-3-ylmethanamines
    Patent number: 9376409
    Abstract: This invention relates to methods for making oxetan-3-ylmethanamines having the formula (I) wherein R1? and R2? are as defined herein. The methods of the invention provide the compounds of formula (I) in high yields and under conditions amenable for large-scale commercial production.
    Type: Grant
    Filed: May 1, 2013
    Date of Patent: June 28, 2016
    Assignee: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Magnus Carl Arne Eriksson, Suresh R. Kapadia, Jonathan Timothy Reeves, Xingzhong Zeng
  • Process for making -sulfinyl ?-amino amides
    Patent number: 9079832
    Abstract: Disclosed is a process for making diastereomeric N-sulfinyl ?-amino amides by reaction of chiral sulfinimines with formamides and lithium diisopropylamide. The process of the invention provides the N-sulfinyl ?-amino amides in high yields and with high diastereoselectivity.
    Type: Grant
    Filed: November 5, 2013
    Date of Patent: July 14, 2015
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Jonathan Timothy Reeves, Chris H. Senanayake
  • METHODS FOR MAKING OXETAN-3-YLMETHANAMINES
    Publication number: 20150119589
    Abstract: This invention relates to methods for making oxetan-3-ylmethanamines having the formula (I) wherein R1? and R2? are as defined herein. The methods of the invention provide the compounds of formula (I) in high yields and under conditions amenable for large-scale commercial production.
    Type: Application
    Filed: May 1, 2013
    Publication date: April 30, 2015
    Inventors: Magnus Carl Arne Eriksson, Suresh R. Kapadia, Jonathan Timothy Reeves, Xingzhong Zeng
  • PROCESS FOR MAKING N-SULFINYL a-AMINO AMIDES
    Publication number: 20140171641
    Abstract: Disclosed is a process for making diastereomeric N-sulfinyl ?-amino amides by reaction of chiral sulfinimines with formamides and lithium diisopropylamide. The process of the invention provides the N-sulfinyl ?-amino amides in high yields and with high diastereoselectivity.
    Type: Application
    Filed: November 5, 2013
    Publication date: June 19, 2014
    Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Jonathan Timothy REEVES, Chris H. SENANAYAKE
  • METHODS OF MAKING DIASTEREOMERIC ORGANIC COMPOUNDS
    Publication number: 20140135493
    Abstract: Disclosed is a process for making diastereomeric compound of the formula (I): wherein m, n and R1 to R4 are as defined herein. The process of the invention provides the compound of formula (I) in high yield and substantially free of the corresponding diastereomers. The compounds of formula (I) prepared by the process of the invention are useful for making pharmaceutically active compounds such as 11-?-hydroxysteroid hydrogenase type 1 (11-?-HSD1) inhibitors.
    Type: Application
    Filed: December 15, 2011
    Publication date: May 15, 2014
    Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Daniel Robert Fandrick, Zhi-Hui Lu, Diana Crimhilda Reeves, Jonathan Timothy Reeves, Chris Hugh Senanayake, Jinhua J. Song, Yongda Zhang
  • Glucocorticoid mimetics, methods of making them, pharmaceutical compositions and uses thereof
    Patent number: 8268859
    Abstract: Compounds of Formula (I) wherein R1, R2, X, and Y are as defined herein, or a tautomer, optical isomer, prodrug, co-crystal, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.
    Type: Grant
    Filed: June 3, 2009
    Date of Patent: September 18, 2012
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Christian Harcken, Rajashekhar Betageri, Todd Bosanac, Michael Jason Burke, Soojin Kim, Daniel Kuzmich, Thomas Wai-ho Lee, Zhibin Li, Pingrong Liu, John Lord, Hossein Razavi, Jonathan Timothy Reeves, David Thomson
  • Pyridinyl Compounds Useful As Intermediates
    Publication number: 20120136158
    Abstract: Disclosed are compounds of the formula (I), useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of CCR1 including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. Also disclosed are intermediates thereof, and methods of making and methods of using same.
    Type: Application
    Filed: February 8, 2012
    Publication date: May 31, 2012
    Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Brian Nicholas COOK, Darren DiSALVO, Daniel Robert FANDRICK, Christian HARCKEN, Daniel KUZMICH, Thomas Wai-Ho LEE, Pingrong LIU, John LORD, Can MAO, Jochen NEU, Brian Christopher RAUDENBUSH, Hossein RAZAVI, Jonathan Timothy REEVES, Jinhua J. SONG, Alan David SWINAMER, Zhulin TAN
  • Azaindazole Compounds As CCR1 Receptor Antagonists
    Publication number: 20120035370
    Abstract: Disclosed are compounds of the formula (I), useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of CCR1 including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. Also disclosed are intermediates thereof, and methods of making and methods of using same.
    Type: Application
    Filed: October 14, 2011
    Publication date: February 9, 2012
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Brian Nicholas COOK, Darren DiSALVO, Daniel Robert FANDRICK, Christian HARCKEN, Daniel KUZMICH, Thomas Wai-Ho LEE, Pingrong LIU, John LORD, Can MAO, Jochen NEU, Brian Christopher RAUDENBUSH, Hossein RAZAVI, Jonathan Timothy REEVES, Jinhua J. SONG, Alan David SWINAMER, Zhulin TAN
  • STEREOSELECTIVE SYNTHESIS OF CERTAIN TRIFLUOROMETHYL-SUBSTITUTED ALCOHOLS
    Publication number: 20110275808
    Abstract: A process for stereoselective synthesis of a compound of Formula (I) wherein R1, R2, R3, R4, and R5 are as described herein.
    Type: Application
    Filed: April 28, 2009
    Publication date: November 10, 2011
    Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Jonathan Timothy Reeves, Jinhau J. Song, Zhulin Tan
  • Process for Synthesis of Intermediates Useful for Making Substituted Indazole and Azaindazole Compounds
    Publication number: 20110137042
    Abstract: Disclosed are processes for preparing compounds of formula (I): the compounds are useful as intermediates for preparing indazole and azaindazole substituted compounds.
    Type: Application
    Filed: December 1, 2010
    Publication date: June 9, 2011
    Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Hossein RAZAVI, Jonathan Timothy REEVES, Sonia RODRIGUEZ
  • Azaindazole compounds as CCR1 receptor antagonists
    Patent number: 7879873
    Abstract: Disclosed are compounds of the formula (I), useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of CCR1 including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. Also disclosed are methods of making and methods of using same.
    Type: Grant
    Filed: September 22, 2009
    Date of Patent: February 1, 2011
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Brian Nicholas Cook, Darren DiSalvo, Daniel Robert Fandrick, Christian Harcken, Daniel Kuzmich, Thomas Wai-Ho Lee, Pingrong Liu, John Lord, Can Mao, Jochen Neu, Brian Christopher Raudenbush, Hossein Razavi, Jonathan Timothy Reeves, Jinhua J. Song, Alan David Swinamer, Zhulin Tan
  • Azaindazole Compounds As CCR1 Receptor Antagonists
    Publication number: 20100093724
    Abstract: Disclosed are compounds of the formula (I), useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of CCR1 including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. Also disclosed are methods of making and methods of using same.
    Type: Application
    Filed: September 22, 2009
    Publication date: April 15, 2010
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Brian Nicholas COOK, Darren DiSALVO, Daniel Robert FANDRICK, Christian HARCKEN, Daniel KUZMICH, Thomas Wai-Ho LEE, Pingrong LIU, John LORD, Can MAO, Jochen NEU, Brian Christopher RAUDENBUSH, Hossein RAZAVI, Jonathan Timothy REEVES, Jinhua J. SONG, Alan David SWINAMER, Zhulin TAN
  • Glucocorticoid Mimetics, Methods of Making Them, Pharmaceutical Compositions and Uses Thereof
    Publication number: 20090325988
    Abstract: Compounds of Formula (I) wherein R1, R2, X, and Y are as defined herein, or a tautomer, optical isomer, prodrug, co-crystal, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.
    Type: Application
    Filed: June 3, 2009
    Publication date: December 31, 2009
    Applicant: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Christian Harcken, Rajashekhar Betageri, Todd Bosanac, Michael Jason Burke, Soojin Kim, Daniel Kuzmich, Thomas Wai-Ho Lee, Zhibin Li, Pingrong Liu, John Lord, Hossein Razavi, Jonathan Timothy Reeves, Daivd Thomson