Abstract: Selectively providing voltage-gated sodium channel function sufficient to rescue impaired Nav1.1 function to inhibitory neurons is described. Provided voltage-gated sodium channel function sufficient to rescue impaired Nav1.1 function in inhibitory neurons can be used to treat disorders such as epilepsy, and more particularly, Dravet Syndrome.

Abstract: A twelve-transistor (12T) memory cell for a memory device that includes a transmission gate, a cross-coupled inverter circuit operably connected to the transmission gate, and a tri-state inverter operably connected to the cross-coupled inverter circuit. The cross-coupled inverter includes another tri-state inverter cross-coupled to an inverter circuit. Various operations for the 12T memory cell, as well as circuitry to perform the operations, are disclosed.

Abstract: A computer-implemented method of simulating operation of an electric drive unit to predict one or more performance parameters of the electric drive unit is provided. The electric drive unit comprises at least an electric motor. The method comprises obtaining parameters defining physical properties of the electric motor, obtaining parameters defining drive currents for driving the electric motor, processing the obtained parameters using a machine learning module trained a priori to predict a spatially varying electromagnetic and/or mechanical and/or thermal profile within the electric motor during operation, and providing as output a predicted profile for the electric motor, and using the predicted profile to compute the one or more performance parameters of the electric drive unit.

Abstract: In an approach, responsibility for reissuing a fetch micro-operation is allocated to a reissue queue subsequent to a cache miss corresponding to a cache and the fetch micro-operation. Responsive to higher level cache returning data to the cache, an issue selection algorithm of the issue queue is overridden to prioritize reissuing the fetch micro-operation.

Abstract: Artificial expression constructs for modulating gene expression in targeted central nervous system cell types are described. The artificial expression constructs can be used to express synthetic genes or modify gene expression in GABAergic or glutamatergic neurons within the thalamus. In some cases, the artificial constructs can also be used to express synthetic genes or modify gene expression in neurons within the thalamus as well as a secondary cell type.

Abstract: A system for determining and merging differentially private approximate distinct-counting sketches is disclosed. A first non-private probabilistic cardinality estimator for a first dataset is determined. The first non-private probabilistic cardinality estimator is converted to a first private probabilistic cardinality estimator for the first dataset with a first noise level. The first private probabilistic cardinality estimator for the first dataset is merged with a second probabilistic cardinality estimator for a second dataset with a second noise level to produce a merged probabilistic cardinality estimator for the first dataset and the second dataset combined together based at least in part on the first noise level and the second noise level. A number of unique elements in the first dataset and the second dataset combined together is estimated based on the merged probabilistic cardinality estimator for the first dataset and the second dataset combined together.

Abstract: Artificial expression constructs for modulating gene expression in targeted central nervous system cell types are described. The artificial expression constructs can be used to express synthetic genes or modify gene expression in claustrum neurons including L6 IT Car3 neurons.

Abstract: A flexible oximeter device for measuring pulse and blood oxygen saturation in tissue includes a first array of first light emitting elements that emit red light, a second array of second light emitting elements that emit green light or near-infrared (NIR) light and an array of sensor elements arranged on at least one flexible substrate. Each sensor element is configured to detect red and green or NIR light, and to output a signal representing an amount of red or green or NIR light detected. The first and second arrays and the array of sensor elements form a plurality of interleaved measurement pixels, each pixel comprising one of the first light emitting elements and a corresponding sensor element, and one of the second light emitting elements and a different corresponding sensor element.

Abstract: Artificial expression constructs for modulating gene expression in GABAergic neurons and astrocytes are described. The artificial expression constructs can be used to express SLC6A1 for the treatment of SLC6A1-associated disorders, among other uses.

Abstract: Artificial expression constructs for modulating gene expression in targeted central nervous system cell types are described. The artificial expression constructs can be used to express synthetic genes or modify gene expression in chandelier cells. Chandelier cells are a subtype of GABAergic interneurons that that have been implicated in disorders such as epilepsy and schizophrenia.

Abstract: In an approach, responsibility for reissuing a fetch micro-operation is allocated to a reissue queue subsequent to a cache miss corresponding to a cache and the fetch micro-operation. Responsive to higher level cache returning data to the cache, an issue selection algorithm of the issue queue is overridden to prioritize reissuing the fetch micro-operation.

Abstract: Artificial expression constructs for modulating gene expression in striatal neurons are described. The artificial expression constructs can be used to express heterologous genes in striatal neurons including in striatal medium spiny neuron-pan, striatal medium spiny neuron-indirect pathway, striatal medium spiny neuron-direct pathway, striatal interneuron-cholinergic, and Drd3+ medium spiny neurons in olfactory tubercle. The artificial expression constructs can be used for many purposes, including to research and treat movement disorders such as Parkinson's disease and Huntington's disease.

Abstract: The present disclosure provides compositions and methods for minimally invasive optogenetic stimulation. More particularly, the present disclosure provides compositions and methods for using an ultra-sensitive step-function opsin for minimally invasive optogenetic stimulation.

Abstract: Artificial expression constructs for selectively modulating gene expression in selected central nervous system cell types are described. The artificial expression constructs can be used to selectively express synthetic genes or modify gene expression in inhibitory neocortical GABAergic neurons including somatostatin GABAergic neurons, parvalbumin GABAergic neurons, vasointestinal peptide GABAergic neurons, Lamp5 GABAergic neurons, and in some instances astrocytes.

Abstract: Artificial expression constructs for selectively modulating gene expression in selected central nervous system cell types are described. Particularly, the artificial expression constructs can be used to selectively express synthetic genes and/or modify gene expression in neocortical glutamatergic layer 5 neurons, such as glutamatergic layer 5 extratelencephalic-projecting (L5 ET) neurons.

Abstract: Artificial expression constructs for selectively modulating gene expression in selected central nervous system cell types are described. The artificial expression constructs can be used to selectively express synthetic genes or modify gene expression in astrocytes, oligodendrocytes, microglia, pericytes, SMC, or endothelial cells.

Abstract: Artificial expression constructs for selectively modulating gene expression in selected central nervous system cell types are described. The artificial expression constructs can be used to selectively express synthetic genes or modify gene expression in GABAergic neurons generally; and/or GABAergic neuron cell types such as lysosomal associated membrane protein 5 (Lamp5) neurons; vasoactive intestinal polypeptide-expressing (Vip) neurons; somatostatin (Sst) neurons; and/or parvalbumin (Pvalb) neuron cell types. Certain artificial expression constructs additionally drive selective gene expression in Layer 4 and/or layer 5 intratelencephalic (IT) neurons, deep cerebellar nuclear neurons or cerebellar Purkinje cells.

Abstract: Artificial expression constructs for selectively modulating gene expression in selected central nervous system cell types are described. The artificial expression constructs can be used to selectively express synthetic genes or modify gene expression in excitatory cortical neurons, such as primarily within cortical layers 2/3, 4, 5, and 6 and including those with extratelencephalic (ET) projections, intratelencephalic (IT) projections, and pyramidal tract (PT) projections, among others.

Abstract: A flexible oximeter device for measuring pulse and blood oxygen saturation in tissue includes a first array of first light emitting elements that emit red light, a second array of second light emitting elements that emit green light or near-infrared (NIR) light and an array of sensor elements arranged on at least one flexible substrate. Each sensor element is configured to detect red and green or NIR light, and to output a signal representing an amount of red or green or NIR light detected. The first and second arrays and the array of sensor elements form a plurality of interleaved measurement pixels, each pixel comprising one of the first light emitting elements and a corresponding sensor element, and one of the second light emitting elements and a different corresponding sensor element.

Abstract: A computer-implemented method for detecting vulnerabilities in microarchitectures. A non-limiting example of the computer-implemented method includes creating a simulation for execution on a model of a microarchitecture, the simulation including a set of instructions and a placeholder for holding a piece of secret data. The computer-implemented method executes the simulation a first time on the model of the microarchitecture with a first piece of secret data stored in the placeholder and stores a first output of the first executed simulation. The computer-implemented method executes the simulation a second time on the model of the microarchitecture with a second piece of secret data stored in the placeholder and stores a second output of the second executed simulation. The computer-implemented method compares the first output with the second output and provides an indication of a microarchitecture vulnerability when there is a difference between the first output and the second output.