Abstract: Embodiments of the instant disclosure relate to compositions and methods of making and using ATP-competitive Ca2+/Calmodulin-Dependent Protein Kinase II (CaMKII) inhibitors for treating a health condition. In certain embodiments, the health condition includes, but is not limited to, a health condition concerning the brain, and targeting the brain with one or more ATP-competitive CaMKII inhibitor to prevent, ameliorate, or treat the health condition. In some embodiments, ATP competitive CaMKII inhibitors of use herein preserve, restore, or induce long-term potentiation (LTP) mechanisms in the subject. In some embodiments, the health condition includes a chronic health condition, and the treatment includes a prolonged treatment of a subject having such a chronic health condition.

Abstract: A method of forming microdroplets is provided that includes forming a well plate, using lithography, where the well plate includes a microchannel and a microwell in a surface of the fluid channel, flowing a first fluid into the microchannel, where the microchannel and the microwell are filled with the first fluid, and flowing a second fluid into the microchannel, where the first fluid is displaced from the microchannel, where the first fluid remains in the microwell, where a microdroplet of the first fluid is formed.

Abstract: A method of forming microdroplets is provided that includes forming a well plate, using lithography, where the well plate includes a microchannel and a microwell in a surface of the fluid channel, flowing a first fluid into the microchannel, where the microchannel and the microwell are filled with the first fluid, and flowing a second fluid into the microchannel, where the first fluid is displaced from the microchannel, where the first fluid remains in the microwell, where a microdroplet of the first fluid is formed.