Abstract: An apparatus for isolating rare cells from a blood sample is disclosed. The apparatus includes a reservoir for supplying the blood sample and a pump for receiving the blood sample. The apparatus also includes a microchip and a set of magnets. The microchip has a microchannel formed between the microchip and a glass slide. The microchannel is connected between the reservoir and the pump to allow the blood sample to flow from the reservoir to the pump. The set of magnets is located adjacent to the glass slide to form a magnetic gradient along the glass slide on which rare cells can be isolated from the blood sample.

Abstract: Anti-ErbB2 antibodies are described which bind to an epitope in Domain 1 of ErbB2 and induce cell death via apoptosis. Various uses for these antibodies are also described.

Abstract: This invention discloses monoclonal antibodies (MAbs) which have little or no signaling activity as monomers become potent anti-tumor agents when they are converted into homoconjugates. The homoconjugates exert anti-growth activity by signaling G0/G1 arrest or apoptosis, depending upon which cell surface molecule they bind. This activity is specific and does not require an Fc portion. These conjugates are potent, anti-tumor agents.