Patents by Inventor Jonathan W. Francis

Jonathan W. Francis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Superoxide dismutase/tetanus toxin fragment C hybrid protein
    Patent number: 5780024
    Abstract: Disclosed is a 68 kD recombinant hybrid protein comprising an enzymatically active Cu/Zn superoxide dismutase ("SOD-1") moiety and a tetanus toxin fragment C ("TTC") moiety, wherein the TTC moiety selectively delivers the hybrid protein into neurons, and the SOD-1 moiety retains substantial enzymatic activity, following neuronal uptake. Also disclosed are a DNA expression vector encoding the hybrid protein.
    Type: Grant
    Filed: June 21, 1996
    Date of Patent: July 14, 1998
    Assignees: The General Hospital Corp., University of Maryland at Baltimore
    Inventors: Robert H. Brown, Paul S. Fishman, Jonathan W. Francis, Betsy A. Hosler