Abstract: An aqueous multi-phase system for diagnosis of sickle cell disease is described, including two or more phase-separated phases including: a first aqueous phase including a first phase component and having a first density between about 1.025 g/cm3 and about 1.095 g/cm3; and a second aqueous phase including a second phase component and having a second density between about 1.100 g/cm3 and about 1.140 g/cm3; wherein the first density is lower than the second density; and each of the first and second phase components include at least one polymer.

Abstract: Multi-phase systems and kits using these multiphase systems are described. The Multi-phase system described herein comprises multiple phase-separated phases each comprises a phase component and the phases, taken together, represent a density gradient. The kit comprising the multiphase system as described herein may be used to separate biological analytes such as cells. Non-limiting examples of the biological analytes include normal erythrocyte with hemoglobin Hb AA, Hb CC, and Hb AS, sickle cell erythrocyte with hemoglobin Hb SS and Hb SC, reticulocyte, iron deficiency anemia red blood cell, ?-thalessemia trait red blood cell, and normal red blood cell.

Abstract: A device includes a sensor to detect a parameter related to a diagnostic test. A controller is coupled to the sensor to receive sensed information from the sensor and generate data representative of the parameter. A tone generator encodes the data and provides audio tones to couple to a communication device.