Abstract: This disclosure relates to novel SARS-CoV-2 targeting sequences. Novel SARS-CoV-2 targeting oligonucleotides for the treatment of SARS-CoV-2 infection are also provided.

Abstract: Provided herein, in various embodiments, are methods of treating a fragile X-associated disorder (e.g., fragile X syndrome), comprising administering to a subject in need thereof, a therapeutically effective amount of an agent that decreases expression of an aberrant fragile X messenger ribonucleoprotein 1 (FMR1) gene product (e.g., FMR1-217). Also provided herein, in various embodiments, are compositions (e.g., polynucleotides such as antisense oligonucleotides or pharmaceutical compositions) for decreasing expression of an aberrant FMR1 gene product.

Abstract: This disclosure relates to novel SARS-CoV-2 targeting sequences. Novel SARS-CoV-2 targeting oligonucleotides for the treatment of SARS-CoV-2 infection are also provided.

Abstract: This disclosure relates to compounds (“siRNASO”) comprising a double stranded RNA (dsRNA) attached to antisense oligonucleotides (ASO) and heteroduplex oligonucleotides (HDO). Also provided are methods of inhibiting gene expression with the same.

Abstract: In a method for applying deterministic logic to select resources for resource genomes in a genetic algorithm, a logic engine identifies resources associated with an objective and an overall task population to be completed by one or more of the identified resources. The logic engine then selects a deterministic logical framework from one or more deterministic logical frameworks based on the objective. Following the selection of a deterministic logical framework, the logic engine selects one or more resources from the one or more identified resources based on the selected deterministic logical framework. The logic engine compiles the one or more selected resources into a resource genome, assigns one or more tasks from the task population to the one or more selected resources, and sends instructions to the one or more selected resources to execute the one or more tasks. The logic engine determines a value score for the resource genome.

Abstract: The present disclosure provides antisense compounds, methods, and compositions for silencing ADAM33 mRNA. The present disclosure provides antisense compounds, methods, and compositions for the treatment, prevention, or amelioration of diseases, disorders, and conditions associated with ADAM33 in a subject in need thereof. Also contemplated are antisense compounds and methods for the preparation of a medicament for the treatment, prevention, or amelioration of a disease, disorder, or condition associated with ADAM33.

Abstract: This disclosure relates to novel SARS-CoV-2 targeting sequences. Novel SARS-CoV-2 targeting oligonucleotides for the treatment of SARS-CoV-2 infection are also provided.

Abstract: The present disclosure provides antisense compounds, methods, and compositions for silencing ADAM33 mRNA. The present disclosure provides antisense compounds, methods, and compositions for the treatment, prevention, or amelioration of diseases, disorders, and conditions associated with ADAM33 in a subject in need thereof. Also contemplated are antisense compounds and methods for the preparation of a medicament for the treatment, prevention, or amelioration of a disease, disorder, or condition associated with ADAM33.

Abstract: In a method for applying deterministic logic to select resources for resource genomes in a genetic algorithm, a logic engine identifies resources associated with an objective and an overall task population to be completed by one or more of the identified resources. The logic engine then selects a deterministic logical framework from one or more deterministic logical frameworks based on the objective. Following the selection of a deterministic logical framework, the logic engine selects one or more resources from the one or more identified resources based on the selected deterministic logical framework. The logic engine compiles the one or more selected resources into a resource genome, assigns one or more tasks from the task population to the one or more selected resources, and sends instructions to the one or more selected resources to execute the one or more tasks. The logic engine determines a value score for the resource genome.

Abstract: The present disclosure provides antisense compounds, methods, and compositions for increasing FXN gene expression. The present disclosure provides antisense compounds, methods, and compositions for the treatment, prevention, or amelioration of diseases, disorders, and conditions associated with FXN in a subject in need thereof. Also contemplated are antisense compounds and methods for the preparation of a medicament for the treatment, prevention, or amelioration of a disease, disorder, or condition associated with FXN.

Abstract: In a method for applying deterministic logic to select resources for resource genomes in a genetic algorithm, a logic engine identifies resources associated with an objective and an overall task population to be completed by one or more of the identified resources. The logic engine then selects a deterministic logical framework from one or more deterministic logical frameworks based on the objective. Following the selection of a deterministic logical framework, the logic engine selects one or more resources from the one or more identified resources based on the selected deterministic logical framework. The logic engine compiles the one or more selected resources into a resource genome, assigns one or more tasks from the task population to the one or more selected resources, and sends instructions to the one or more selected resources to execute the one or more tasks. The logic engine determines a value score for the resource genome.

Abstract: In a method for applying deterministic logic to select resources for resource genomes in a genetic algorithm, a logic engine identifies resources associated with an objective and an overall task population to be completed by one or more of the identified resources. The logic engine then selects a deterministic logical framework from one or more deterministic logical frameworks based on the objective. Following the selection of a deterministic logical framework, the logic engine selects one or more resources from the one or more identified resources based on the selected deterministic logical framework. The logic engine compiles the one or more selected resources into a resource genome, assigns one or more tasks from the task population to the one or more selected resources, and sends instructions to the one or more selected resources to execute the one or more tasks. The logic engine determines a value score for the resource genome.

Abstract: A case for protecting a portable electronic device includes a cushion member formed from a single piece of elastomeric material and having a first portion, a second portion, and a hinge portion connecting the first portion to the second portion permitting articulation of the installed portable electronic device. The case also includes a first rigid shell member removably attachable to the portable electronic device over the first portion of the cushion member, wherein the cushion member extends substantially between the first rigid shell member and the installed portable electronic device. The case also includes a second rigid shell member removably attachable to the portable electronic device over the second portion of the cushion member, wherein the cushion member extends substantially between the second rigid shell member and the installed portable electronic device.

Abstract: A case for protecting a portable electronic device includes a first member, a second member, and a flexible hinge member. The first member is removably attachable to a first portion of the portable electronic device for covering an outer surface of the first portion of the portable electronic device while not covering a display screen area of the portable electronic device. The second member of the case is removably attachable to a second portion of the portable electronic device for covering the outer surface of the second portion of the portable electronic device while not covering the display. The flexible hinge member is in proximity to a hinging portion of the portable electronic device when the case is attached. The flexible hinge member permits articulation of the portable electronic device when the case is attached to the portable electronic device due to flexing of a flexible material.

Abstract: A case for protecting a portable electronic device includes a cushion member formed from a single piece of elastomeric material and having a first portion, a second portion, and a hinge portion connecting the first portion to the second portion permitting articulation of the installed portable electronic device. The case also includes a first rigid shell member removably attachable to the portable electronic device over the first portion of the cushion member, wherein the cushion member extends substantially between the first rigid shell member and the installed portable electronic device. The case also includes a second rigid shell member removably attachable to the portable electronic device over the second portion of the cushion member, wherein the cushion member extends substantially between the second rigid shell member and the installed portable electronic device.

Abstract: The present disclosure provides antisense compounds, methods, and compositions for silencing ADAM33 mRNA. The present disclosure provides antisense compounds, methods, and compositions for the treatment, prevention, or amelioration of diseases, disorders, and conditions associated with ADAM33 in a subject in need thereof. Also contemplated are antisense compounds and methods for the preparation of a medicament for the treatment, prevention, or amelioration of a disease, disorder, or condition associated with ADAM33.

Abstract: A protective cover for an electronic device includes a first hardshell member, a second hardshell member, and a flexible hinge member. The first hardshell member removably attaches to a first portion of the electronic device to protect the first portion of the electronic device. The second hardshell member removably attaches to a second portion of the electronic device to protect the second portion of the electronic device. The flexible hinge member includes a flexible material and is attached to the first hardshell member and the second hardshell member such that the flexible hinge member aligns with a hinge of the electronic device. The flexible hinge member flexes to allow the second portion of the electronic device to remain articulable relative to the first portion of the electronic device when the protective cover is on the electronic device.

Abstract: A case for protecting a portable electronic device includes a first member, a second member, and a flexible hinge member. The first member is removably attachable to a first portion of the portable electronic device for covering an outer surface of the first portion of the portable electronic device while not covering a display screen area of the portable electronic device. The second member of the case is removably attachable to a second portion of the portable electronic device for covering the outer surface of the second portion of the portable electronic device while not covering the display. The flexible hinge member is in proximity to a hinging portion of the portable electronic device when the case is attached. The flexible hinge member permits articulation of the portable electronic device when the case is attached to the portable electronic device due to flexing of a flexible material.

Abstract: A protective cover for a portable computing device includes a first hardshell component, a second hardshell component, and a hinging element. The first hardshell component removably snaps onto a first portion of the portable computing device to protect the first portion of the portable computing device. The second hardshell component removably snaps onto a second portion of the portable computing device to protect the second portion of the portable computing device. The hinging element comprises a flexible material and is attached to the first hardshell component and the second hardshell component such that the hinging element of the protective cover aligns with the hinging structure of the portable computing device. The hinging element flexes to allow the second portion of the portable computing device to remain articulable relative to the first portion of the portable computing device when the protective cover is installed on the portable computing device.

Abstract: A protective cover for an electronic device includes a first hardshell member, a second hardshell member, and a flexible hinge member. The first hardshell member removably attaches to a first portion of the electronic device to protect the first portion of the electronic device. The second hardshell member removably attaches to a second portion of the electronic device to protect the second portion of the electronic device. The flexible hinge member includes a flexible material and is attached to the first hardshell member and the second hardshell member such that the flexible hinge member aligns with a hinge of the electronic device. The flexible hinge member flexes to allow the second portion of the electronic device to remain articulable relative to the first portion of the electronic device when the protective cover is on the electronic device.