Abstract: Neuroinflammation mediated by microglia and infiltrating peripheral immune cells is a major component of stroke pathophysiology. The calcium activated potassium channel KCa3.1 is expressed selectively in the injured CNS by microglia, and KCa3.1 function has been implicated in proinflammatory activation of microglia. KCa3.1 is further implicated in the pathophysiology of ischemia/reperfusion (stroke) related brain injury. Senicapoc, an investigational drug with a proven safety profile and shown to cross the blood-brain barrier, is a potent and selective KCa3.1 inhibitor that intervenes in the inflammation cascade that follows ischemia/reperfusion, and is a potential treatment for stroke.

Abstract: Neuroinflammation mediated by microglia and infiltrating peripheral immune cells is a major component of stroke pathophysiology. The calcium activated potassium channel KCa3.1 is expressed selectively in the injured CNS by microglia, and KCa3.1 function has been implicated in proinflammatory activation of microglia. KCa3.1 is further implicated in the pathophysiology of ischemia/reperfusion (stroke) related brain injury. Senicapoc, an investigational drug with a proven safety profile and shown to cross the blood-brain barrier, is a potent and selective KCa3.1 inhibitor that intervenes in the inflammation cascade that follows ischemia/reperfusion, and is a potential treatment for stroke.

Abstract: Neuroinflammation mediated by microglia and infiltrating peripheral immune cells is a major component of stroke pathophysiology. The calcium activated potassium channel KCa3.1 is expressed selectively in the injured CNS by microglia, and KCa3.1 function has been implicated in proinflammatory activation of microglia. KCa3.1 is further implicated in the pathophysiology of ischemia/reperfusion (stroke) related brain injury. Senicapoc, an investigational drug with a proven safety profile and shown to cross the blood-brain barrier, is a potent and selective KCa3.1 inhibitor that intervenes in the inflammation cascade that follows ischemia/reperfusion, and is a potential treatment for stroke.

Abstract: An elbow silencer is disclosed comprising a casing and a baffle defining a flow channel. The elbow silencer is constructed to be modular so that two or more complementary elbow silencers are capable of engaging in a nesting relationship. The nested, complementary elbow silencers comprise substantially similar flow channels to produce predictable acoustic attenuation, self generated noise and pressure loss.

Abstract: An elbow silencer is disclosed comprising a casing and a baffle defining a flow channel. The elbow silencer is constructed to be modular so that two or more complementary elbow silencers are capable of engaging in a nesting relationship. The nested, complementary elbow silencers comprise substantially similar flow channels to produce predictable acoustic attenuation, self generated noise and pressure loss.

Abstract: In a room that is RF shielded and acoustically insulated, a plurality of panels are fastened together to form a self-supported structure. The panels are fabricated from a continuous metal sheathing and filled with acoustic insulating material. The panels are fastened together by joiners and compression clamps. Structural steel tubing can be fastened between the panels when additional structural strength is required. Access to the interior of the room is provided by a metal door that is filled with acoustic insulating material. The door also includes both RF and acoustic seals. The door is equipped with special hinges that enable the door to be flush mounted and to be opened 180.degree..