Patents by Inventor JONATHAN WEISSMAN

JONATHAN WEISSMAN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR EPIGENOME EDITING
    Publication number: 20230212323
    Abstract: Provided herein are, inter alia, compositions and methods for modulating gene expression.
    Type: Application
    Filed: June 4, 2021
    Publication date: July 6, 2023
    Inventors: Luke Gilbert, Jonathan Weissman, James Nunez, Greg Pommier
  • Compositions and Methods for Gene Editing
    Publication number: 20230124253
    Abstract: Provided herein are, inter alia, compositions and methods for manipulation of genomes of living organisms.
    Type: Application
    Filed: July 29, 2022
    Publication date: April 20, 2023
    Inventors: Jin Chen, Luke Gilbert, James Nunez, Jonathan Weissman
  • COMPOSITIONS AND METHODS FOR GENE EDITING
    Publication number: 20230103909
    Abstract: Provided herein are, inter alia, compositions and methods for manipulation of genomes of living organisms.
    Type: Application
    Filed: April 21, 2022
    Publication date: April 6, 2023
    Inventors: Jin Chen, Luke Gilbert, James Nunez, Jonathan Weissman
  • Compositions and methods for gene editing
    Patent number: 11434491
    Abstract: Provided herein are, inter alia, compositions and methods for manipulation of genomes of living organisms.
    Type: Grant
    Filed: October 19, 2020
    Date of Patent: September 6, 2022
    Assignee: The Regents of the University of California
    Inventors: Jin Chen, Luke Gilbert, James Nunez, Jonathan Weissman
  • CONTROL OF MAMMALIAN GENE DOSAGE USING CRISPR
    Publication number: 20220259593
    Abstract: The present disclosure provides methods and compositions for precisely controlling the expression levels of mammalian genes using CRISPRi or CRISPRa and one or more modified sgRNAs. The methods and compositions are useful for, inter alia, titrating the expression of a gene of interest, identifying drug targets and mechanisms of drug resistance, and enabling the analysis of and control over metabolic and signaling pathway fluxes.
    Type: Application
    Filed: January 25, 2022
    Publication date: August 18, 2022
    Applicant: The Regents of the University of California
    Inventors: Jonathan Weissman, Marco Jost, Maximilian A. Horlbeck, Daniel Santos, Reuben Saunders
  • Assays for massively combinatorial perturbation profiling and cellular circuit reconstruction
    Patent number: 11214797
    Abstract: The present invention provides tools and methods for the systematic analysis of genetic interactions, including higher order interactions. The present invention provides tools and methods for combinatorial probing of cellular circuits, for dissecting cellular circuitry, for delineating molecular pathways, and/or for identifying relevant targets for therapeutics development.
    Type: Grant
    Filed: April 27, 2018
    Date of Patent: January 4, 2022
    Assignees: The Broad Institute, Inc., Massachusetts Institute of Technology, The Regents of the University of California
    Inventors: Aviv Regev, Brittany Adamson, Brian Cleary, Le Cong, Atray Dixit, Jellert Gaublomme, Eric S. Lander, Thomas Norman, Oren Parnas, Orit Rozenblatt-Rosen, Alexander K. Shalek, Jonathan Weissman
  • COMPOSITIONS AND METHODS FOR GENE EDITING
    Publication number: 20210139918
    Abstract: Provided herein are, inter alia, compositions and methods for manipulation of genomes of living organisms.
    Type: Application
    Filed: October 19, 2020
    Publication date: May 13, 2021
    Inventors: Jin Chen, Luke Gilbert, James Nunez, Jonathan Weissman
  • Pooled method for high throughput screening of trans factors affecting RNA levels
    Patent number: 10815479
    Abstract: Provided herein are methods directed to multiplexed detection of the modulation of transcriptional activity using perturbation elements.
    Type: Grant
    Filed: June 7, 2016
    Date of Patent: October 27, 2020
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Onn Brandman, Jonathan Weissman, Calvin H. Jan, Luke A. Gilbert
  • COMPOSITIONS AND METHODS FOR CRISPR-BASED SCREENING
    Publication number: 20190300868
    Abstract: Provided herein are compositions and methods for CRISPR-based screening.
    Type: Application
    Filed: December 15, 2017
    Publication date: October 3, 2019
    Inventors: Luke Gilbert, Maximilian A. Horlbeck, Marco Jost, Jonathan Weissman
  • ASSAYS FOR MASSIVELY COMBINATORIAL PERTURBATION PROFILING AND CELLULAR CIRCUIT RECONSTRUCTION
    Publication number: 20190085324
    Abstract: The present invention provides tools and methods for the systematic analysis of genetic interactions, including higher order interactions. The present invention provides tools and methods for combinatorial probing of cellular circuits, for dissecting cellular circuitry, for delineating molecular pathways, and/or for identifying relevant targets for therapeutics development.
    Type: Application
    Filed: April 27, 2018
    Publication date: March 21, 2019
    Inventors: Aviv Regev, Brittany Adamson, Brian Cleary, Le Cong, Atray Dixit, Jellert Gaublomme, Eric S. Lander, Thomas Norman, Oren Parnas, Orit Rozenblatt-Rosen, Alexander K. Shalek, Jonathan Weissman
  • Methods for genome-wide screening and construction of genetic interaction maps
    Patent number: 10144927
    Abstract: The present invention provides methods for conducting screens using nucleic acid elements (e.g., interfering RNAs) to confidently identify hit genetic elements. The present invention further comprises constructing vectors that contain two or more nucleic acid elements to knock down all pairwise combinations of the hit genetic elements identified from the screen. Following quantitation of the single and double-knockdown phenotypes, genetic interactions between all gene pairs can be calculated. Genes can then be clustered according to the similarity of the pattern of their interactions with all of the other genes to obtain a genetic interaction map, which can advantageously be used to predict functional associations between genes and identify drug targets for therapy such as combination cancer therapy.
    Type: Grant
    Filed: August 12, 2014
    Date of Patent: December 4, 2018
    Assignee: The Regents of the University of California
    Inventors: Martin Kampmann, Michael Bassik, Jonathan Weissman
  • Methods for detecting modification resistant nucleic acids
    Patent number: 9677068
    Abstract: Methods are provided for, inter alia, detecting nucleic acid molecules resistant to degradation, such as a plurality of RNA molecules bound to a ribosome, using various technologies including deep sequencing.
    Type: Grant
    Filed: February 5, 2016
    Date of Patent: June 13, 2017
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Jonathan Weissman, Nicholas Ingolia, Sina Ghaemmaghami, John Newman
  • POOLED METHOD FOR HIGH THROUGHPUT SCREENING OF TRANS FACTORS AFFECTING RNA LEVELS
    Publication number: 20160362684
    Abstract: Provided herein are methods directed to multiplexed detection of the modulation of transcriptional activity using perturbation elements.
    Type: Application
    Filed: June 7, 2016
    Publication date: December 15, 2016
    Applicant: The Regents of the University of California
    Inventors: Onn Brandman, Jonathan Weissman, Calvin H. Jan, Luke A. Gilbert
  • METHODS FOR DETECTING MODIFICATION RESISTANT NUCLEIC ACIDS
    Publication number: 20160326519
    Abstract: Methods are provided for, inter alia, detecting nucleic acid molecules resistant to degradation, such as a plurality of RNA molecules bound to a ribosome, using various technologies including deep sequencing.
    Type: Application
    Filed: February 5, 2016
    Publication date: November 10, 2016
    Inventors: Jonathan Weissman, Nicholas Ingolia, Sina Ghaemmaghami, John Newman
  • Methods for detecting modification resistant nucleic acids
    Patent number: 9284547
    Abstract: Methods are provided for, inter alia, detecting nucleic acid molecules resistant to degradation, such as a plurality of RNA molecules bound to a ribosome, using various technologies including deep sequencing.
    Type: Grant
    Filed: April 22, 2013
    Date of Patent: March 15, 2016
    Assignee: The Regents of the University of California
    Inventors: Jonathan Weissman, Nicholas Ingolia, Sina Ghaemmaghami, John Newman
  • Methods of identifying a cellular nascent RNA transcript
    Patent number: 9284604
    Abstract: Methods and compositions for identifying a cellular nascent RNA transcript are provided.
    Type: Grant
    Filed: May 22, 2013
    Date of Patent: March 15, 2016
    Assignee: The Regents of the University of California
    Inventors: Jonathan Weissman, Lee Stirling Churchman
  • METHODS FOR GENOME-WIDE SCREENING AND CONSTRUCTION OF GENETIC INTERACTION MAPS
    Publication number: 20150072893
    Abstract: The present invention provides methods for conducting screens using nucleic acid elements (e.g., interfering RNAs) to confidently identify hit genetic elements. The present invention further comprises constructing vectors that contain two or more nucleic acid elements to knock down all pairwise combinations of the hit genetic elements identified from the screen. Following quantitation of the single and double-knockdown phenotypes, genetic interactions between all gene pairs can be calculated. Genes can then be clustered according to the similarity of the pattern of their interactions with all of the other genes to obtain a genetic interaction map, which can advantageously be used to predict functional associations between genes and identify drug targets for therapy such as combination cancer therapy.
    Type: Application
    Filed: August 12, 2014
    Publication date: March 12, 2015
    Inventors: Martin Kampmann, Michael Bassik, Jonathan Weissman
  • METHODS OF IDENTIFYING A CELLULAR NASCENT RNA TRANSCRIPT
    Publication number: 20140030706
    Abstract: Methods and compositions for identifying a cellular nascent RNA transcript are provided.
    Type: Application
    Filed: May 22, 2013
    Publication date: January 30, 2014
    Applicant: The Regents of the University of California
    Inventors: Jonathan Weissman, Lee Stirling Churchman
  • METHODS FOR DETECTING MODIFICATION RESISTANT NUCLEIC ACIDS
    Publication number: 20130288905
    Abstract: Methods are provided for, inter alia, detecting nucleic acid molecules resistant to degradation, such as a plurality of RNA molecules bound to a ribosome, using various technologies including deep sequencing.
    Type: Application
    Filed: April 22, 2013
    Publication date: October 31, 2013
    Inventors: Jonathan Weissman, Nicholas Ingolia, Sina Ghaemmaghami, John Newman
  • Methods for detecting modification resistant nucleic acids
    Patent number: 8486865
    Abstract: Methods are provided for, inter alia, detecting nucleic acid molecules resistant to degradation, such as a plurality of RNA molecules bound to a ribosome, using various technologies including deep sequencing.
    Type: Grant
    Filed: November 3, 2009
    Date of Patent: July 16, 2013
    Assignee: The Regents of the University of California
    Inventors: Jonathan Weissman, Nicholas Ingolia, Sina Ghaemmaghami, John Newman